Chemical composition of essential oil from Lindera caesia Reinw. ex Fern.-Vill. and its antifungal, antibiofilm, and molecular docking studies

• Published in: NATURAL PRODUCT RESEARCH
• Main Authors: Zaini, Nur Nabilah Mohd; Salleh, Wan Mohd Nuzul Hakimi Wan; Arzmi, Mohd Hafiz; Salihu, Abubakar Siddiq; Ab Ghani, Nurunajah
• Format: Article; Early Access
• Language: English
• Published: TAYLOR & FRANCIS LTD 2023
• Subjects: Chemistry; Pharmacology & Pharmacy
• Online Access: https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001133034000001
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2023.2298720

The chemical composition, antifungal, antibiofilm, and molecular docking studies of the essential oil obtained from Lindera caesia were investigated. A total of thirty-nine components (96.7%) were identified using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The major components included terpinen-4-ol (26.3%), neo-intermedeol (23.2%), eudesma-4,11-dien-3-one (10.4%), and o-cymene (5.3%). The antifungal activity was tested against Candida albicans and Streptococcus mutans using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. The essential oil exhibited activity against C. albicans (MIC 125 mu g/mL) and S. mutans (MIC 250 mu g/mL), and increased the biofilm of C. albicans by 31.25% when treated with 500 mu g/mL. The molecular docking study shows neo-intermedeol, eudesma-4,11-dien-3-one, alpha-selinene, and beta-selinene as the good candidate to target Erg11 with a binding energy of -7.3 kcal/mol. These findings demonstrated that the essential oil may have potential in dental application for caries prevention. [Graphical Abstract]