| Summary: | Syzygium filiforme var. filiforme Chantar. & J.Parn. is a plant variety from the dicotyledonous plant family (Myrtaceae). This work is designed to examine the chemical composition and cytotoxicity of Syzygium filiforme essential oil. The essential oil was obtained through hydrodistillation and the volatile components were analysed using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS) techniques. The cytotoxicity of essential oil was evaluated using an MTT assay. A total of 34 chemical components, which constitute 96.1% of oil content, were successfully identified. The most abundant components were alpha-cadinol (23.3%), t-muurolol (9.1%), geraniol (6.6%), germacrene D (6.3%), and gamma-gurjunene (5.0%). The essential oil exhibited cytotoxicity against three cancer cell lines which are HepG2, MCF7, and A549 with the IC50 values ranging from 70.2-88.1 mu g/mL. The current study highlights the potential of the use of essential oils as an alternative to the development of pharmaceutical anti-chemopreventive or cosmetics.
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