In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review
This review highlights in vitro drug dissolution/permeation methods available for topical and transdermal nanocarriers that have been designed to modulate the propensity of drug release, drug penetration into skin, and permeation into systemic circulation. Presently, a few of USFDA-approved in vitro...
| Published in: | AAPS PharmSciTech |
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| Main Author: | |
| Format: | Review |
| Language: | English |
| Published: |
Springer New York LLC
2019
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064531332&doi=10.1208%2fs12249-019-1362-7&partnerID=40&md5=670898e9a34f95aea122bb4030a8b478 |
| Summary: | This review highlights in vitro drug dissolution/permeation methods available for topical and transdermal nanocarriers that have been designed to modulate the propensity of drug release, drug penetration into skin, and permeation into systemic circulation. Presently, a few of USFDA-approved in vitro dissolution/permeation methods are available for skin product testing with no specific application to nanocarriers. Researchers are largely utilizing the in-house dissolution/permeation testing methods of nanocarriers. These drug release and permeation methods are pending to be standardized. Their biorelevance with reference to in vivo plasma concentration–time profiles requires further exploration to enable translation of in vitro data for in vivo or clinical performance prediction. © 2019, American Association of Pharmaceutical Scientists. |
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| ISSN: | 15309932 |
| DOI: | 10.1208/s12249-019-1362-7 |