Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
A series of N'-(substituted)-4-(butan-2-ylideneamino)benzohydrazides (1-21) was synthesized and characterized by physicochemical as well as spectral means. The synthesized compounds were screened for their in vitro antimicrobial and anticancer potentials. The synthesized compounds displayed hig...
| الحاوية / القاعدة: | Arabian Journal of Chemistry |
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| المؤلف الرئيسي: | |
| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Elsevier
2014
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| الوصول للمادة أونلاين: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905580114&doi=10.1016%2fj.arabjc.2013.05.010&partnerID=40&md5=344cb7e9d656c1359baf1f37bf84c90c |
| id |
Saini M.; Kumar P.; Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Narasimhan B. |
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| spelling |
Saini M.; Kumar P.; Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Narasimhan B. 2-s2.0-84905580114 Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides 2014 Arabian Journal of Chemistry 7 4 10.1016/j.arabjc.2013.05.010 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905580114&doi=10.1016%2fj.arabjc.2013.05.010&partnerID=40&md5=344cb7e9d656c1359baf1f37bf84c90c A series of N'-(substituted)-4-(butan-2-ylideneamino)benzohydrazides (1-21) was synthesized and characterized by physicochemical as well as spectral means. The synthesized compounds were screened for their in vitro antimicrobial and anticancer potentials. The synthesized compounds displayed higher antifungal potential as compared to antibacterial potential. Besides having good antifungal potential, the synthesized compounds were having appreciable anticancer potential and a number of compounds displayed higher anticancer potential than the standard drug, carboplatin. The results of QSAR studies demonstrated the importance of steric parameter, molar refractivity (MR), topological parameters, third order molecular connectivity index (3χ), Kier's first order shape index (κ1) in describing the antimicrobial activity of N'-(substituted)-4-(butan-2-ylideneamino)benzohydrazides. © 2013 . Elsevier 18785352 English Article All Open Access; Gold Open Access |
| author |
2-s2.0-84905580114 |
| spellingShingle |
2-s2.0-84905580114 Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides |
| author_facet |
2-s2.0-84905580114 |
| author_sort |
2-s2.0-84905580114 |
| title |
Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides |
| title_short |
Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides |
| title_full |
Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides |
| title_fullStr |
Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides |
| title_full_unstemmed |
Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides |
| title_sort |
Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides |
| publishDate |
2014 |
| container_title |
Arabian Journal of Chemistry |
| container_volume |
7 |
| container_issue |
4 |
| doi_str_mv |
10.1016/j.arabjc.2013.05.010 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905580114&doi=10.1016%2fj.arabjc.2013.05.010&partnerID=40&md5=344cb7e9d656c1359baf1f37bf84c90c |
| description |
A series of N'-(substituted)-4-(butan-2-ylideneamino)benzohydrazides (1-21) was synthesized and characterized by physicochemical as well as spectral means. The synthesized compounds were screened for their in vitro antimicrobial and anticancer potentials. The synthesized compounds displayed higher antifungal potential as compared to antibacterial potential. Besides having good antifungal potential, the synthesized compounds were having appreciable anticancer potential and a number of compounds displayed higher anticancer potential than the standard drug, carboplatin. The results of QSAR studies demonstrated the importance of steric parameter, molar refractivity (MR), topological parameters, third order molecular connectivity index (3χ), Kier's first order shape index (κ1) in describing the antimicrobial activity of N'-(substituted)-4-(butan-2-ylideneamino)benzohydrazides. © 2013 . |
| publisher |
Elsevier |
| issn |
18785352 |
| language |
English |
| format |
Article |
| accesstype |
All Open Access; Gold Open Access |
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1828987883145396224 |