Computational analysis of protein–protein interactions in motile T-cells

Analysis of protein–protein interactions is important for better understanding of molecular mechanisms involved in immune regulation and has potential for elaborating avenues for drug discovery targeting T-cell motility. Currently, only a small fraction of protein–protein interactions have been char...

詳細記述

書誌詳細
出版年:Methods in Molecular Biology
第一著者: 2-s2.0-85059493704
フォーマット: Book chapter
言語:English
出版事項: Humana Press Inc. 2019
オンライン・アクセス:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85059493704&doi=10.1007%2f978-1-4939-9036-8_18&partnerID=40&md5=f520a32217aca7835fc5a346cc1a8486
その他の書誌記述
要約:Analysis of protein–protein interactions is important for better understanding of molecular mechanisms involved in immune regulation and has potential for elaborating avenues for drug discovery targeting T-cell motility. Currently, only a small fraction of protein–protein interactions have been characterized in T-lymphocytes although there are several detection methods available. In this regard, computational approaches garner importance, with the continued explosion of genomic and proteomic data, for handling protein modeling and protein–protein interactions in large scale. Here, we describe a computational method to identify protein–protein interactions based on in silico protein design. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
ISSN:10643745
DOI:10.1007/978-1-4939-9036-8_18