Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones
Substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones 1-27 were evaluated for their activity against Leishmania major. Compounds 1-27 demonstrated in vitro antileishmanial activities with IC50 values between 28.9 - 69.05 μM, as compared to standard drug pentamidine (IC50 = 5.09 ± 0.04 μM)...
| الحاوية / القاعدة: | Journal of the Chemical Society of Pakistan |
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| المؤلف الرئيسي: | |
| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Chemical Society of Pakistan
2015
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| الوصول للمادة أونلاين: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953334043&partnerID=40&md5=5c722873b2bfb3f6c5e69f55420e57ae |
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Khan S.R.; Ghouri N.; Karim A.; Naz F.; Fakhri M.I.; Perveen S.; Khan K.M.; Taha M.; Choudhary M.I. |
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Khan S.R.; Ghouri N.; Karim A.; Naz F.; Fakhri M.I.; Perveen S.; Khan K.M.; Taha M.; Choudhary M.I. 2-s2.0-84953334043 Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones 2015 Journal of the Chemical Society of Pakistan 37 5 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953334043&partnerID=40&md5=5c722873b2bfb3f6c5e69f55420e57ae Substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones 1-27 were evaluated for their activity against Leishmania major. Compounds 1-27 demonstrated in vitro antileishmanial activities with IC50 values between 28.9 - 69.05 μM, as compared to standard drug pentamidine (IC50 = 5.09 ± 0.04 μM). Compounds 12 (IC50 = 28.90 ± 1.10 μM), 24 (IC50 = 31.4 ± 2.15 μM), 13 (IC50 = 35.0 ± 3.18 μM), 16 (IC50 = 35.0 ± 3.13 μM), and 25 (IC50 = 35.0 ± 3.18μM) displayed signifiant antileishmanial activities. Whereas, compounds 8-10, 15, 19, and 26 with IC50 values of 62.2 ± 3.36, 57.8 ± 2.30, 57.72 ± 5.02, 56.18 ± 4.40, 57.85 ± 2.25, 69.05 ± 6.20, 54.8 ± 1.50, and 57.8 ± 2.30 μM showed a moderate antileishmanial activities. Chemical Society of Pakistan 2535106 English Article |
| author |
2-s2.0-84953334043 |
| spellingShingle |
2-s2.0-84953334043 Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones |
| author_facet |
2-s2.0-84953334043 |
| author_sort |
2-s2.0-84953334043 |
| title |
Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones |
| title_short |
Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones |
| title_full |
Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones |
| title_fullStr |
Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones |
| title_full_unstemmed |
Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones |
| title_sort |
Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones |
| publishDate |
2015 |
| container_title |
Journal of the Chemical Society of Pakistan |
| container_volume |
37 |
| container_issue |
5 |
| doi_str_mv |
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| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953334043&partnerID=40&md5=5c722873b2bfb3f6c5e69f55420e57ae |
| description |
Substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones 1-27 were evaluated for their activity against Leishmania major. Compounds 1-27 demonstrated in vitro antileishmanial activities with IC50 values between 28.9 - 69.05 μM, as compared to standard drug pentamidine (IC50 = 5.09 ± 0.04 μM). Compounds 12 (IC50 = 28.90 ± 1.10 μM), 24 (IC50 = 31.4 ± 2.15 μM), 13 (IC50 = 35.0 ± 3.18 μM), 16 (IC50 = 35.0 ± 3.13 μM), and 25 (IC50 = 35.0 ± 3.18μM) displayed signifiant antileishmanial activities. Whereas, compounds 8-10, 15, 19, and 26 with IC50 values of 62.2 ± 3.36, 57.8 ± 2.30, 57.72 ± 5.02, 56.18 ± 4.40, 57.85 ± 2.25, 69.05 ± 6.20, 54.8 ± 1.50, and 57.8 ± 2.30 μM showed a moderate antileishmanial activities. |
| publisher |
Chemical Society of Pakistan |
| issn |
2535106 |
| language |
English |
| format |
Article |
| accesstype |
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| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1828987881891299328 |