Carbohydrazones as new class of carbonic anhydrase inhibitors: Synthesis, kinetics, and ligand docking studies

QR Code

Carbohydrazones as new class of carbonic anhydrase inhibitors: Synthesis, kinetics, and ligand docking studies

Discovery and development of carbonic anhydrase inhibitors is crucial for their clinical use as antiepileptic, diurectic and antiglaucoma agents. Keeping this in mind, we have synthesized carbohydrazones 1–27 and evaluated them for their in vitro carbonic anhydrase inhibitory potential. Out of twent...

书目详细资料
发表在:	Bioorganic Chemistry
主要作者:	2-s2.0-85017101492
格式:	文件
语言:	English
出版:	Academic Press Inc. 2017
在线阅读:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017101492&doi=10.1016%2fj.bioorg.2017.03.014&partnerID=40&md5=7b441424767eec38cc62eeac138faf38

相似书籍

Benzimidazoles: A new class of carbonic anhydrase inhibitors
由: 2-s2.0-84879718744
出版: (2013)

Thiadiazole derivatives as New Class of β-glucuronidase inhibitors
由: 2-s2.0-84961126449
出版: (2016)

Convergent synthesis of carbonic anhydrase inhibiting bi-heterocyclic benzamides: Structure–activity relationship and mechanistic explorations through enzyme inhibition, kinetics, and computational studies
由: 2-s2.0-85100860135
出版: (2021)

New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights
由: 2-s2.0-79958793776
出版: (2011)

Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
由: 2-s2.0-85179140411
出版: (2024)

Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease
由: 2-s2.0-84940020718
出版: (2015)

Dithiocarbazate Ligand-Based Cu(II), Ni(II), and Zn(II) Complexes: Synthesis, Structural Investigations, Cytotoxicity, DNA Binding, and Molecular Docking Studies
由: 2-s2.0-85135689592
出版: (2022)

Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease
由: 2-s2.0-85071689548
出版: (2019)

Discovery of novel 1,8-naphthalimide piperazinamide based benzenesulfonamides derivatives as potent carbonic anhydrase IX inhibitors and ferroptosis inducers for the treatment of triple-negative breast cancer
由: 2-s2.0-85197352734
出版: (2024)

Synthesis of piperazine sulfonamide analogs as diabetic-II inhibitors and their molecular docking study
由: 2-s2.0-85032929001
出版: (2017)

Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies
由: 2-s2.0-84946228073
出版: (2015)

Synthesis, in vitro biological analysis and molecular docking studies of new thiadiazole-based thiourea derivatives as dual inhibitors of a-amylase and a-glucosidase
由: 2-s2.0-85162946909
出版: (2023)

Synthesis of novel indazole derivatives as inhibitors of diabetics II along with molecular docking and simulation study
由: 2-s2.0-85207018388
出版: (2025)

Synthesis of new oxadiazole derivatives as α-glucosidase inhibitors
由: 2-s2.0-84937512790
出版: (2015)

Synthesis of novel triazinoindole-based thiourea hybrid: A study on α-glucosidase inhibitors and their molecular docking
由: 2-s2.0-85074173138
出版: (2019)

Synthesis of oxadiazole-coupled-thiadiazole derivatives as a potent β-glucuronidase inhibitors and their molecular docking study
由: Taha M.; Imran S.; Alomari M.; Rahim F.; Wadood A.; Mosaddik A.; Uddin N.; Gollapalli M.; Alqahtani M.A.; Bamarouf Y.A.
出版: (2019)

Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
由: 2-s2.0-85144315169
出版: (2023)

Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes
由: 2-s2.0-85101323909
出版: (2021)

Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies
由: 2-s2.0-84928815461
出版: (2015)

Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives
由: 2-s2.0-84984780886
出版: (2016)

Synthesis, biological evaluation, and molecular docking study of novel 1,2,4-substituted triazoles as inhibitors of alzheimer’s disease
由: 2-s2.0-85136203736
出版: (2022)

Composition of overlapping protein-protein and protein-ligand interfaces
由: 2-s2.0-84951058673
出版: (2015)

Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies
由: 2-s2.0-84948649641
出版: (2016)

Synthesis and molecular docking of new hydrazones derived from ethyl isonipecotate and their biological activities
由: 2-s2.0-85020078563
出版: (2017)

New benzimidazole based Schiff bases as potent anti-alzheimer agents: Synthesis, bio-evaluation and molecular docking study
由: 2-s2.0-85189482031
出版: (2024)

Synthesis, Kinetics and Computational Explorations of 4-Phenylpiperazine Bearing N-(Aryl)-3-substituted-benzamides as Auspicious Tyrosinase Inhibitors
由: 2-s2.0-85187520882
出版: (2024)

Synthesis, kinetics, binding conformations and structure-activity relationship of potent tyrosinase inhibitors: Aralkylated 2-aminothiazole-ethyltriazole hybrids
由: 2-s2.0-85111424369
出版: (2021)

Effect of Temperature and CO2 Flowrate on the Formation of CaCO3 in the Hydration Reaction of CO2 Catalyzed by Immobilized Carbonic anhydrase into PVDF Membrane
由: Abdullah S.N.; Hamzah F.; Husain N.C.; Veny H.; Rodhi M.N.M.; Mohidem N.A.
出版: (2023)

Identification of Potent Inhibitors of Alzheimer's Disease Based on Benzodioxin-Thiosemicarbazide Analogues and Molecular Docking Study
由: 2-s2.0-85219522570
出版: (2025)

Convergent synthesis, kinetics and computational attributions of indole-N-phenyltriazole hybrids bearing N-(aryl)butanamides as alkaline phosphatase inhibitors
由: 2-s2.0-85201787582
出版: (2025)

Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches
由: 2-s2.0-85076239103
出版: (2020)

Identification of Potent Inhibitors of Alzheimer's Disease Based on Benzodioxin-Thiosemicarbazide Analogues and Molecular Docking Study
由: Taha, et al.
出版: (2025)

The β-carboline analogs as a potent inhibitor for Alzheimer's Disease, molecular docking and dynamics simulation study
由: 2-s2.0-85173583185
出版: (2023)

Synthesis and Molecular Docking Study of Hydrazone Schiff Bases of α-Naphthalene-Containing Alkyl Phenyl Ether Fragment as Potent α-Amylase and α-Glucosidase Inhibitors
由: 2-s2.0-85208551606
出版: (2024)

Paddy Diseases Multi-Class Classification using CNN Variants
由: 2-s2.0-85189140711
出版: (2023)

New benzoxazole-based sulphonamide hybrids analogs as potent inhibitors of α-amylase and α-glucosidase: Synthesis and in vitro evaluation along with in silico study
由: 2-s2.0-85140093344
出版: (2022)

Syntheses, in vitro evaluation and molecular docking studies of 5-bromo-2-aryl benzimidazoles as α-glucosidase inhibitors
由: 2-s2.0-84979210899
出版: (2016)

Morpholine hydrazone scaffold: Synthesis, anticancer activity and docking studies
由: 2-s2.0-85006698949
出版: (2017)

Adsorption Isotherm and Kinetic Study of Methane on Palm Kernel Shell-Derived Activated Carbon
由: 2-s2.0-85142444467
出版: (2023)

Teacher experiences in converting classes to distance learning in the covid-19 pandemic
由: 2-s2.0-85099654511
出版: (2021)