Exploration of synthetic multifunctional amides as new therapeutic agents for Alzheimer's disease through enzyme inhibition, chemoinformatic properties, molecular docking and dynamic simulation insights

QR Code

Exploration of synthetic multifunctional amides as new therapeutic agents for Alzheimer's disease through enzyme inhibition, chemoinformatic properties, molecular docking and dynamic simulation insights

A new series of multifunctional amides has been synthesized having moderate enzyme inhibitory potentials and mild cytotoxicity. 2-Furyl(1-piperazinyl)methanone (1) was coupled with 3,5-dichloro-2-hydroxybenzenesulfonyl chloride (2) to form {4-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1-piperazinyl}(2...

書目詳細資料
發表在:	Journal of Theoretical Biology
主要作者:	2-s2.0-85053905014
格式:	Article
語言:	English
出版:	Academic Press 2018
在線閱讀:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053905014&doi=10.1016%2fj.jtbi.2018.09.018&partnerID=40&md5=389296c4a0639983b208beb994df0448

相似書籍

Designing of promising medicinal scaffolds for Alzheimer's disease through enzyme inhibition, lead optimization, molecular docking and dynamic simulation approaches
由: 2-s2.0-85070881566
出版: (2019)

Synthesis of Flurbiprofen Based Amide Derivatives as Potential Leads for Diabetic Management: In Vitro α-glucosidase Inhibition, Molecular Docking and DFT Simulation Approach
由: 2-s2.0-85191891273
出版: (2024)

Synthesis, enzyme inhibitory kinetics mechanism and computational study of N-(4-methoxyphenethyl)-N-(substituted)- 4-methylbenzenesulfonamides as novel therapeutic agents for Alzheimer's disease
由: 2-s2.0-85049259205
出版: (2018)

Nanoparticles as potential clinical therapeutic agents in Alzheimer’s disease: focus on selenium nanoparticles
由: 2-s2.0-85021103809
出版: (2017)

Synthesis, biological evaluation, molecular docking and dynamic simulation of novel benzofuran derivatives as potential agents against Alzheimer's disease
由: 2-s2.0-85206074124
出版: (2025)

Synthesis, enzyme inhibition and molecular docking studies of 1- arylsulfonyl-4-Phenylpiperazine derivatives
由: 2-s2.0-85027267562
出版: (2017)

The β-carboline analogs as a potent inhibitor for Alzheimer's Disease, molecular docking and dynamics simulation study
由: 2-s2.0-85173583185
出版: (2023)

Synthesis and structure-activity relationship of tyrosinase inhibiting novel bi-heterocyclic acetamides: Mechanistic insights through enzyme inhibition, kinetics and computational studies
由: 2-s2.0-85061452076
出版: (2019)

Synthesis, characterization, enzyme inhibition and molecular docking studies of benzothiazole derivatives bearing alkyl phenyl ether fragments
由: 2-s2.0-85200412227
出版: (2025)

Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Rosmarinus officinalis against Alzheimer’s Disease
由: 2-s2.0-85141550803
出版: (2022)

New benzimidazole based Schiff bases as potent anti-alzheimer agents: Synthesis, bio-evaluation and molecular docking study
由: 2-s2.0-85189482031
出版: (2024)

Design of potent tyrosinase inhibiting N-arylated-4-yl-benzamides bearing 2-aminothiazole-triazole bi-heterocycles: mechanistic insight through enzyme inhibition, kinetics and computational studies
由: 2-s2.0-85194053288
出版: (2024)

Secondary metabolite profiling, antioxidant capacity, enzyme inhibitory potential and in silico studies of Launaea intybacea (Jacq.) Beauverd: A multifunctional approach to probe into the new nutraceuticals
由: 2-s2.0-85171583023
出版: (2023)

Synthesis of Some New N-Alkyl/Aralkyl-N-(2,3-Dihydro-1,4-Benzodioxin-6-YL)-4-Bromobenzenesulfonamides as Possible Therapeutic Agents F or Alzheimer’s Disease
由: 2-s2.0-85127408369
出版: (2022)

Synthesis of some new N-(alkyl/aralkyl)-N-(2,3-dihydro-1,4-benzodioxan-6-yl)-4-chlorobenzenesulfonamides as possible therapeutic agents for Alzheimer’s disease and Type-2 Diabetes
由: 2-s2.0-85061745776
出版: (2019)

Investigation of novel benzimidazole-based indole/thiazole hybrids derivatives as effective anti-diabetics and anti-alzheimer's agents: Structure-activity relationship insight, in vitro and in silico approaches
由: 2-s2.0-85193900160
出版: (2024)

Angiotensin converting enzyme (ACE)-peptide interactions: Inhibition kinetics, in silico molecular docking and stability study of three novel peptides generated from palm kernel cake proteins
由: 2-s2.0-85072981873
出版: (2019)

Synthesis of benzimidazole–based analogs as anti alzheimer’s disease compounds and their molecular docking studies
由: 2-s2.0-85093694209
出版: (2020)

Discovery of amide-functionalized benzimidazolium salts as potent α-glucosidase inhibitors
由: 2-s2.0-85112329694
出版: (2021)

Is metformin a therapeutic paradigm for colorectal cancer: Insight into the molecular pathway?
由: 2-s2.0-85019587803
出版: (2017)

Synthesis, biological and computational evaluation of benzoxazole hybrid analogs as potential anti-Alzheimer's agents
由: 2-s2.0-85204151475
出版: (2024)

Identification of Potent Inhibitors of Alzheimer's Disease Based on Benzodioxin-Thiosemicarbazide Analogues and Molecular Docking Study
由: Taha, et al.
出版: (2025)

Identification of Potent Inhibitors of Alzheimer's Disease Based on Benzodioxin-Thiosemicarbazide Analogues and Molecular Docking Study
由: 2-s2.0-85219522570
出版: (2025)

Comprehensive insights into oral squamous cell carcinoma: Diagnosis, pathogenesis, and therapeutic advances
由: 2-s2.0-85200435313
出版: (2024)

Synthetic N-aralkylated-N-(2,4-dimethylphenyl)benzenesulfonamides: As potent anti-bacterial agents
由: 2-s2.0-85009833752
出版: (2016)

Convergent synthesis of carbonic anhydrase inhibiting bi-heterocyclic benzamides: Structure–activity relationship and mechanistic explorations through enzyme inhibition, kinetics, and computational studies
由: 2-s2.0-85100860135
出版: (2021)

Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease
由: 2-s2.0-84940020718
出版: (2015)

In vitro antioxidant and in silico enzyme inhibition studies of Carissa carandas Linn.: potential ingredient for nutraceutical development
由: 2-s2.0-85206217859
出版: (2024)

Insights into the Role of LncRNAs and miRNAs in Glioma Progression and Their Potential as Novel Therapeutic Targets
由: Kciuk M.; Yahya E.B.; Mohamed M.M.I.; Abdulsamad M.A.; Allaq A.A.; Gielecińska A.; Kontek R.
出版: (2023)

Clean technology option development for smart and multifunctional construction materials: Sustainable geopolymer composites
由: Asim N.; Badiei M.; Samsudin N.A.; Mohammad M.; Razali H.; Hui D.
出版: (2024)

Insight into the Structure and Physicochemical Properties of Potent Chemokine Receptor 5 Inhibitors for the Discovery of Novel Alzheimer’s Disease Drugs
由: Yusof N.I.S.M.; Awaluddin N.A.; Fauzi F.M.
出版: (2023)

Synthesis, biological evaluation, and molecular docking study of novel 1,2,4-substituted triazoles as inhibitors of alzheimer’s disease
由: 2-s2.0-85136203736
出版: (2022)

Antibacterial activity of Garcinia spp. by molecular docking simulations: an overview
由: Zaine N.F.Z.; Abd Halim A.N.; Saat R.; Mian V.J.Y.; Zamakshshari N.H.
出版: (2024)

Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives
由: 2-s2.0-85042298379
出版: (2018)

Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation
由: 2-s2.0-84905899348
出版: (2014)

Governance in crisis: do different types of ownership influence firm performance in GCC countries amid Covid-19?
由: Alshdaifat, et al.
出版: (2025)

Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents
由: 2-s2.0-85191352219
出版: (2024)

Synthesis of some unique carbamate derivatives bearing 2-furoyl-1-piperazine as a valuable therapeutic agents
由: 2-s2.0-85016141011
出版: (2017)

A Review on Multifunctional Carbon-Dots Synthesized From Biomass Waste: Design/ Fabrication, Characterization and Applications
由: 2-s2.0-85105588109
出版: (2021)

Hybrid benzothiazole analogs as antiurease agent: Synthesis and molecular docking studies
由: 2-s2.0-84962360234
出版: (2016)