The potential effects of isoflavones on nuclear receptor modulation in bone remodeling: A review

• 發表在: Journal of Applied Pharmaceutical Science
• 主要作者: 2-s2.0-85166311773
• 格式: Article
• 語言: English
• 出版: Open Science Publishers LLP Inc. 2023
• 在線閱讀: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85166311773&doi=10.7324%2fJAPS.2023.126975&partnerID=40&md5=1368c69b52696d17fd7425f93d601f6a

Isoflavones are plant-based compounds that act as phytoestrogens by mimicking the action of estrogen. Osteoblasts and osteoclasts are the key cells for bone remodeling, a process that includes bone proliferation, differentiation, deposition, and resorption. Studies have demonstrated that isoflavones, a class of flavonoids found almost exclusively in soybeans, could prevent bone loss. Recent findings revealed that isoflavones could activate nuclear receptors (NRs) and regulate bone formation and resorption processes. This current research discussed the principal actions of isoflavones mediated by NRs on bone remodeling such as steroid receptors (estrogen receptor, estrogen-related receptor, and and rogen receptor) and metabolic receptors including peroxisome proliferator-activated receptor-γ Isoflavones modulate osteogenesis by fine-tuning physiological responses on NR sensors and their transcriptional networks. Hence, this present review will dive deep into the use of several isoflavones as potential osteoporosis treatment through NR-controlling gene regulation. © 2023 Haryati Ahmad Hairi et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).