Synthesis, spectral analysis and biological evaluation of N-alkyl/aralkyl/aryl-4-chlorobenzenesulfonamide derivatives

QR Code

Synthesis, spectral analysis and biological evaluation of N-alkyl/aralkyl/aryl-4-chlorobenzenesulfonamide derivatives

New potent organic compounds were synthesized with an aim of good biological activities such as antibacterial and anti-enzymatic. Three series of sulfonamide derivatives were synthesized by treating N-alkyl/aryl substituted amines (2a-f) with 4-chlorobenzensulfonyl chloride (1) to yield N-alkyl/aryl...

Full description

Bibliographic Details
Published in:	Pakistan Journal of Pharmaceutical Sciences
Main Author:	2-s2.0-84989919539
Format:	Article
Language:	English
Published:	Pakistan Journal of Pharmaceutical Sciences 2016
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84989919539&partnerID=40&md5=24e4124b601e571c9d5809e19b599435

Similar Items

Synthesis of some new N-(alkyl/aralkyl)-N-(2,3-dihydro-1,4-benzodioxan-6-yl)-4-chlorobenzenesulfonamides as possible therapeutic agents for Alzheimer’s disease and Type-2 Diabetes
by: 2-s2.0-85061745776
Published: (2019)

Synthesis, spectral analysis and biological evaluation of 2-{[(morpholin-4-yl)ethyl]thio}-5-phenyl/aryl-1,3,4-oxadiazole derivatives
by: 2-s2.0-85107334212
Published: (2021)

Synthesis of some new N-(alkyl/aralkyl)-N-(4-methoxyphenethyl) benzenesulfonamides as antibacterial agents against Escherichia coli
by: 2-s2.0-85072317017
Published: (2019)

Synthesis, spectral analysis and biological evaluation of sulfamoyl and 1,3,4-oxadiazole derivatives of 3-pipecoline
by: 2-s2.0-85069160361
Published: (2019)

Synthesis, Bacterial biofilm inhibition and cytotoxicity of new N-Alkyl/aralkyl-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-nitrobenzenesulfonamides
by: 2-s2.0-85077925901
Published: (2020)

Synthesis of some new 2-[4-(2-furoyl)-1-piperazinyl]-N-aryl/aralkyl acetamides as potent antibacterial agents
by: 2-s2.0-85047722240
Published: (2018)

Synthesis of Some New N-Alkyl/Aralkyl-N-(2,3-Dihydro-1,4-Benzodioxin-6-YL)-4-Bromobenzenesulfonamides as Possible Therapeutic Agents F or Alzheimer’s Disease
by: 2-s2.0-85127408369
Published: (2022)

Synthesis, Spectral Evaluation and in Silico Studies of S-Aralkylated 5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols: As suitable Alzheimer's disease drug candidates
by: 2-s2.0-85121793476
Published: (2021)

Synthesis, antibacterial and lipoxygenase inhibition studies of N-(Alkyl/aralkyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-methylbenzenesulfonamides; [N-(Alkil/aralkil)-N-(2,3-dihidro-1,4-benzodioksin-6-il)-4-metilbenzensülfonamitlerin Sentezi ile Antibakteriyel ve Lipoksijenaz İnhibitör Özellikleri]
by: 2-s2.0-85013177487
Published: (2017)

Synthesis of 2-{[5-(aralkyl/aryl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(4-methyl-1,3-thiazol-2-yl)acetamides: Novel bi-heterocycles as potential therapeutic agents
by: 2-s2.0-85047927389
Published: (2018)

Synthetic N-aralkylated-N-(2,4-dimethylphenyl)benzenesulfonamides: As potent anti-bacterial agents
by: 2-s2.0-85009833752
Published: (2016)

Benzoxazole derivatives: design, synthesis and biological evaluation
by: 2-s2.0-85051455759
Published: (2018)

Synthesis, spectral analysis and pharmacological study of N’-substituted-2-(5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazides
by: 2-s2.0-85006043172
Published: (2016)

Synthesis of 2-Furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives as suitable antibacterial agents with mild cytotoxicity
by: 2-s2.0-85055182626
Published: (2018)

Synthesis, Kinetics and Computational Explorations of 4-Phenylpiperazine Bearing N-(Aryl)-3-substituted-benzamides as Auspicious Tyrosinase Inhibitors
by: 2-s2.0-85187520882
Published: (2024)

Efficient Synthesis of 4-Bromo-N-(1-phenylethyl)benzamide, Arylation by Pd(0) Catalyst, Characterization and DFT Study
by: 2-s2.0-85135826802
Published: (2022)

Synthesis, spectral analysis and antibacterial activity of some novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-oxadiazole derivatives
by: 2-s2.0-85052853089
Published: (2018)

Convergent synthesis, kinetics and computational attributions of indole-N-phenyltriazole hybrids bearing N-(aryl)butanamides as alkaline phosphatase inhibitors
by: 2-s2.0-85201787582
Published: (2025)

4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation
by: Tahlan S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2019)

Synthesis and Biological Evaluation of Coumarin Bearing Thiourea Derivative as Potential Antibacterial Agent
by: Alsukor, et al.
Published: (2024)

Synthesis and Biological Evaluation of Coumarin Bearing Thiourea Derivative as Potential Antibacterial Agent
by: Alsukor A.; Inayatsyah N.A.; Mohamad S.A.S.; Ridhwan M.J.M.; Rasol N.E.; Imran S.
Published: (2024)

Synthesis and Biological Evaluation of Coumarin Bearing Thiourea Derivative as Potential Antibacterial Agent
by: 2-s2.0-85217668581
Published: (2024)

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives
by: 2-s2.0-85029659650
Published: (2017)

Development of N-alkylated benzimidazole based cubosome hydrogel for topical treatment of burns
by: 2-s2.0-85207660913
Published: (2024)

Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents
by: 2-s2.0-85099564407
Published: (2021)

Synthesis and biological evaluation of novel coumarin derivatives bearing sulfonamide moiety as potent α-glucosidase inhibitors
by: Alsukor A.; Inayatsyah N.A.; Ridhwan M.J.M.; Kasim N.; Imran S.
Published: (2025)

Synthesis, characterization, enzyme inhibition and molecular docking studies of benzothiazole derivatives bearing alkyl phenyl ether fragments
by: 2-s2.0-85200412227
Published: (2025)

A facile synthesis of n-alkylated daibucarboline a derivatives via pictet-spengler condensation of tryptamine; [Sintesis mudah terbitan daibukarbolin a melalui kondensasi pictet-spengler daripada triptamin]
by: 2-s2.0-85121333847
Published: (2021)

Biology-oriented drug synthesis (BIODS): In vitro β-glucuronidase inhibitory and in silico studies on 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl carboxylate derivatives
by: 2-s2.0-84998812010
Published: (2017)

Multi-step synthesis of indole-N-ethyltriazole hybrids amalgamated with N-arylated ethanamides: structure-activity relationship and mechanistic explorations through tyrosinase inhibition, kinetics and computational ascriptions
by: 2-s2.0-85127463628
Published: (2022)

Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
by: 2-s2.0-85144315169
Published: (2023)

2-Aminothiazole-Oxadiazole Bearing N-Arylated Butanamides: Convergent Synthesis, Tyrosinase Inhibition, Kinetics, Structure-Activity Relationship, and Binding Conformations
by: 2-s2.0-85146447713
Published: (2023)

Synthesis, biological evaluation, molecular docking and dynamic simulation of novel benzofuran derivatives as potential agents against Alzheimer's disease
by: 2-s2.0-85206074124
Published: (2025)

Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
by: 2-s2.0-85057747839
Published: (2018)

Synthesis, characterization, antibacterial, hemolytic and thrombolytic activity evaluation of 5-(3-chlorophenyl)-2-((N-(substituted)-2-acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives
by: 2-s2.0-85090106052
Published: (2020)

Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents
by: 2-s2.0-85191352219
Published: (2024)

Synthesis, biological evaluation, and molecular docking study of novel 1,2,4-substituted triazoles as inhibitors of alzheimer’s disease
by: 2-s2.0-85136203736
Published: (2022)

Synthesis, multiparametric structure assessment and biological evaluation of some new 1,3,4-oxadiazoles containing piperidine nucleus
by: 2-s2.0-85025480907
Published: (2017)

Synthesis of N-substituted acetamide derivatives of azinane-bearing 1,3,4-oxadiazole nucleus and screening for antibacterial activity
by: 2-s2.0-85014071417
Published: (2017)

Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
by: 2-s2.0-84905580114
Published: (2014)