A facile synthesis of n-alkylated daibucarboline a derivatives via pictet-spengler condensation of tryptamine; [Sintesis mudah terbitan daibukarbolin a melalui kondensasi pictet-spengler daripada triptamin]
A brief and facile approach towards β-carboline and its derivatives is described through a simple three step synthesis. The key reaction involves the construction of β-carboline framework by Pictet-Spengler condensation of tryptamine with various substituted aldehydes. Subsequent aromatization of th...
| 發表在: | Malaysian Journal of Analytical Sciences |
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| 主要作者: | |
| 格式: | Article |
| 語言: | English |
| 出版: |
Malaysian Society of Analytical Sciences
2021
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| 在線閱讀: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121333847&partnerID=40&md5=8f0d0cb2a5baec8629e1fc52defcf044 |
| 總結: | A brief and facile approach towards β-carboline and its derivatives is described through a simple three step synthesis. The key reaction involves the construction of β-carboline framework by Pictet-Spengler condensation of tryptamine with various substituted aldehydes. Subsequent aromatization of the resulting tetrahydro-β-carboline intermediates is achieved via iodine-mediated oxidative dehydrogenation reaction. Thereafter, insertion of alkyl subunit at N-1 position afforded a series of corresponding N-alkylated β-carboline derivatives. The structures of all synthesized intermediates and derivatives of β-carboline, including three new structures (2k, 2l and 3e), were confirmed by NMR, FTIR and GC-MS spectroscopy. © 2021, Malaysian Society of Analytical Sciences. All rights reserved. |
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| ISSN: | 13942506 |