Synthesis of benzimidazole–based analogs as anti alzheimer’s disease compounds and their molecular docking studies

QRコード

Synthesis of benzimidazole–based analogs as anti alzheimer’s disease compounds and their molecular docking studies

We synthesized 10 analogs of benzimidazole-based thiosemicarbazide 1 (a–j) and 13 benzimidazole-based Schiff bases 2 (a–m), and characterized by various spectroscopic techniques and evaluated in vitro for acetylcholinesterase (AchE) and butyrylcholinesterase (BchE) inhibition activities. All the syn...

書誌詳細
出版年:	Molecules
第一著者:	2-s2.0-85093694209
フォーマット:	論文
言語:	English
出版事項:	MDPI AG 2020
オンライン･アクセス:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093694209&doi=10.3390%2fmolecules25204828&partnerID=40&md5=e67ece50533c78c90d8a2924bfca506e

類似資料

New benzimidazole based Schiff bases as potent anti-alzheimer agents: Synthesis, bio-evaluation and molecular docking study
著者:: 2-s2.0-85189482031
出版事項: (2024)

Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease
著者:: 2-s2.0-84940020718
出版事項: (2015)

The β-carboline analogs as a potent inhibitor for Alzheimer's Disease, molecular docking and dynamics simulation study
著者:: 2-s2.0-85173583185
出版事項: (2023)

Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Rosmarinus officinalis against Alzheimer’s Disease
著者:: 2-s2.0-85141550803
出版事項: (2022)

Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents
著者:: 2-s2.0-85191352219
出版事項: (2024)

Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
著者:: 2-s2.0-85144315169
出版事項: (2023)

Synthesis, biological and computational evaluation of benzoxazole hybrid analogs as potential anti-Alzheimer's agents
著者:: 2-s2.0-85204151475
出版事項: (2024)

Hybrid benzothiazole analogs as antiurease agent: Synthesis and molecular docking studies
著者:: 2-s2.0-84962360234
出版事項: (2016)

Identification of Potent Inhibitors of Alzheimer's Disease Based on Benzodioxin-Thiosemicarbazide Analogues and Molecular Docking Study
著者:: 2-s2.0-85219522570
出版事項: (2025)

Identification of Potent Inhibitors of Alzheimer's Disease Based on Benzodioxin-Thiosemicarbazide Analogues and Molecular Docking Study
著者:: Taha, 等
出版事項: (2025)

Synthesis of piperazine sulfonamide analogs as diabetic-II inhibitors and their molecular docking study
著者:: 2-s2.0-85032929001
出版事項: (2017)

Benzoxazole based thiazole hybrid analogs: Synthesis, in vitro cholinesterase inhibition, and molecular docking studies
著者:: 2-s2.0-85145589794
出版事項: (2023)

Synthesis, biological evaluation, and molecular docking study of novel 1,2,4-substituted triazoles as inhibitors of alzheimer’s disease
著者:: 2-s2.0-85136203736
出版事項: (2022)

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs
著者:: 2-s2.0-85044438335
出版事項: (2018)

Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
著者:: 2-s2.0-85074862203
出版事項: (2020)

Synthesis, biological evaluation, molecular docking and dynamic simulation of novel benzofuran derivatives as potential agents against Alzheimer's disease
著者:: 2-s2.0-85206074124
出版事項: (2025)

Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes
著者:: 2-s2.0-85101323909
出版事項: (2021)

Investigation of novel benzimidazole-based indole/thiazole hybrids derivatives as effective anti-diabetics and anti-alzheimer's agents: Structure-activity relationship insight, in vitro and in silico approaches
著者:: 2-s2.0-85193900160
出版事項: (2024)

2-(2'-pyridyl) benzimidazole analogs and their ß-glucuronidase inhibitory activity
著者:: 2-s2.0-84953331043
出版事項: (2015)

Synthesis and novel structural hybrid analogs of oxindole derivatives bearing piperidine ring, their antidiabetics II activity and molecular docking study
著者:: 2-s2.0-85217236617
出版事項: (2025)

Synthesis and novel structural hybrid analogs of oxindole derivatives bearing piperidine ring, their antidiabetics II activity and molecular docking study
著者:: Mukhliss L.; Taha M.; Rahim F.; Adalat B.; Ajmal A.; Wadood A.; Uddin N.; Khan K.M.; Ali Shah S.A.
出版事項: (2025)

Synthesis and novel structural hybrid analogs of oxindole derivatives bearing piperidine ring, their antidiabetics II activity and molecular docking study
著者:: Mukhliss, 等
出版事項: (2025)

Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
著者:: 2-s2.0-85179140411
出版事項: (2024)

Designing of promising medicinal scaffolds for Alzheimer's disease through enzyme inhibition, lead optimization, molecular docking and dynamic simulation approaches
著者:: 2-s2.0-85070881566
出版事項: (2019)

Syntheses, in vitro evaluation and molecular docking studies of 5-bromo-2-aryl benzimidazoles as α-glucosidase inhibitors
著者:: 2-s2.0-84979210899
出版事項: (2016)

Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: A promising approach to develop potential anti-diabetic agents
著者:: 2-s2.0-85209950182
出版事項: (2024)

Exploration of synthetic multifunctional amides as new therapeutic agents for Alzheimer's disease through enzyme inhibition, chemoinformatic properties, molecular docking and dynamic simulation insights
著者:: 2-s2.0-85053905014
出版事項: (2018)

Metabolomics-based profiling with chemometric approach to identify bioactive compounds in Salacca zalacca fruits extracts and in silico molecular docking
著者:: 2-s2.0-85101359053
出版事項: (2021)

Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives
著者:: 2-s2.0-85042298379
出版事項: (2018)

Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies
著者:: 2-s2.0-84946228073
出版事項: (2015)

Synthesis and Nucleotide Pyrophosphatase/Phosphodiesterase Inhibition Studies of Carbohydrazides Based on Benzimidazole-Benzothiazine Skeleton
著者:: 2-s2.0-85097212373
出版事項: (2020)

Synthesis, Spectroscopic Characterization, DFT, Molecular Docking, Catechol Oxidase Activity, and Anti-SARS-CoV-2 of Acylhydrazone Derivatives
著者:: 2-s2.0-85201948344
出版事項: (2025)

Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
著者:: 2-s2.0-85087130142
出版事項: (2020)

Synthesis, Spectroscopic Characterization, DFT, Molecular Docking, Catechol Oxidase Activity, and Anti-SARS-CoV-2 of Acylhydrazone Derivatives
著者:: Anouar E.H.; Filali I.; Shah S.A.A.; Karrouchi K.
出版事項: (2025)

Molecular docking and molecular dynamic simulations of apoptosis proteins with potential anticancer compounds present in Clinacanthus nutans extract using gas chromatography–mass spectrometry
著者:: 2-s2.0-85135177285
出版事項: (2023)

Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies
著者:: 2-s2.0-84928815461
出版事項: (2015)

Synthesis of novel triazinoindole-based thiourea hybrid: A study on α-glucosidase inhibitors and their molecular docking
著者:: 2-s2.0-85074173138
出版事項: (2019)

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives
著者:: 2-s2.0-85029659650
出版事項: (2017)

Streptozotocin mechanisms and its role in rodent models for Alzheimer’s disease
著者:: 2-s2.0-85144019319
出版事項: (2023)

Synthesis, characterization, in-vitro pharmacological assessment and molecular docking studies of trigonelline derivatives
著者:: Singh N.; Yadav S.S.; Kumar S.; Narasihman B.; Ramasamy K.; Lim S.M.; Shah S.A.A.
出版事項: (2025)