Antimicrobial and antiviral effect of cellulose acetate nanofibres doped with pyrrolidone against methicillin-resistant Staphylococcus aureus (MRSA) and human coronavirus 229E (HCoV-229E)

• Published in: Journal of Hazardous Materials Advances
• Main Author: Md. Salleh S.N.; Abdullah M.Z.; Mohamed Saheed M.S.; Mohammat M.F.
• Format: Article
• Language: English
• Published: Elsevier B.V. 2025
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85215376304&doi=10.1016%2fj.hazadv.2025.100598&partnerID=40&md5=4b20f0903fcb4e7cba0c0dfd2d41b8fb

The paper investigated the effectiveness of cellulose acetate (CA) nanofibres doped with a newly synthesized compound against MRSA microbe and HCoV-229E virus. MRSA microbe was responsible for antibiotic resistance diseases and HCoV-229E virus can cause mild to chronic respiratory tract infections. The pyrrolidone compound was synthesized using a one-pot sonochemistry technique and was chemically characterized followed by a toxicological assessment. Subsequently, it was dissolved in a tri-solvent solution containing cellulose acetate and electrospun to create the nanofibre membrane. The resulting membrane underwent characterization and testing against MRSA bacteria and HCoV-229E virus. The findings indicate that the nanofibre membrane, doped with the synthesized pyrrolidone compound, effectively inhibits the growth of MRSA bacteria and HCoV-229E virus. © 2025 The Authors