Mucoadhesive Enhancement of Gelatine by Tannic Acid Crosslinking for Buccal Application

• Published in: Biopolymers
• Main Author: Ahmady A.; Anuar N.K.; Ariffin S.A.; Abu Samah N.H.
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2025
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85213029107&doi=10.1002%2fbip.23646&partnerID=40&md5=0d1ba6f7945ebc28143d1f6d437ed118

This study aims to evaluate the impact of formulation parameters on tannic acid-crosslinked gelatine (GelTA) films, intended as a mucoadhesive matrix for extended buccal drug delivery. GelTA films were prepared using the solvent evaporation technique and screened based on their mucoadhesive and dissolution characteristics. The formulation variables included the source of gelatine (bovine and fish), tannic acid concentration, pH of the film-forming solutions, and the type and concentration of plasticisers. Subsequently, selected films underwent further characterisation (e.g., crosslinking density, stability) to elucidate their features as a drug delivery matrix. GelTA films exhibited a significantly improved dissolution time compared to the non-crosslinked film (BG-GLY20), while maintaining a substantial water uptake capacity conducive to a matrix system with extended action. The bovine GelTA film containing 5% w/w tannic acid and 20% w/w glycerine, prepared at pH 7 (BG-GLY20-7), exhibited a 1.6-fold increase in mucoadhesivity and an extended dissolution time of up to 6 h compared to BG-GLY20 (control), along with superior antioxidant and antimicrobial properties. However, stability studies indicate the need for an oxygen-free environment for film storage. In conclusion, GelTA films show promise as a buccal film matrix, offering extended dissolution times, substantial water uptake, and enhanced adhesive strength. © 2024 Wiley Periodicals LLC.