Exploration of the Out-of-Phase Phenomenon in Shake Flasks by CFD Calculations of Volumetric Power Input, kLa Value and Shear Rate at Elevated Viscosity

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Exploration of the Out-of-Phase Phenomenon in Shake Flasks by CFD Calculations of Volumetric Power Input, kLa Value and Shear Rate at Elevated Viscosity

Culture broth with secreted macromolecules and culture broth of filamentous fungi showing disperse growth exhibit elevated viscosity, usually with shear-thinning flow behavior. High viscosity, however, poses a serious challenge in the production and research of these compounds and organisms. It comm...

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Bibliographic Details
Published in:	Biotechnology and Bioengineering
Main Author:	Dinter C.; Gumprecht A.; Menze M.A.; Azizan A.; Hansen S.; Büchs J.
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2025
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85210735708&doi=10.1002%2fbit.28892&partnerID=40&md5=4f733f750ae21a63c1a73c9e0d14ee25

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