Identification of new structure of indol-3-acetyl-arylsulfonohydrazide as potent α-glucosidase and α-amylase inhibitors and molecular docking

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Identification of new structure of indol-3-acetyl-arylsulfonohydrazide as potent α-glucosidase and α-amylase inhibitors and molecular docking

Herein this work, indole analogs (1–16) were synthesized by treating 2-(1H-indol-3-yl)acetohydrazide with various aryl sulfonyl chloride in pyridine as solvent and screened for α-amylase and α-glucosidase inhibitory activity under positive control of standard drug acarbose (IC50 = 12.80 ± 0.10 μM /1...

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Bibliographic Details
Published in:	Journal of Molecular Structure
Main Author:	Taha M.; Rahim F.; zaman K.; Imran S.; Khan K.M.; Shah S.A.A.; Uddin N.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2025
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85209591318&doi=10.1016%2fj.molstruc.2024.140719&partnerID=40&md5=013b2862aab435f98890306f743723cf

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