D-µ-SPE for Simultaneous Determination of Tetracycline and Bisphenol A in Water Samples using Liquid Chromatography

• Published in: Malaysian Journal of Chemistry
• Main Author: Zulkifli N.M.; Hanapi N.S.M.; Zaini N.; Bonnia N.N.; Joyce S.; Anis A.L.
• Format: Article
• Language: English
• Published: Malaysian Institute of Chemistry 2024
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85209252841&doi=10.55373%2fmjchem.v26i5.598&partnerID=40&md5=089d023441cf3ef5713f28d4a7921618

The present study focuses on the application of dispersive micro solid-phase extraction (D-µ-SPE) in the quantitative analysis of tetracycline (TC) and bisphenol A (BPA) in water samples using high-performance liquid chromatography-diode array detector (HPLC-DAD) with graphene oxide (GO) as the sorbent. By systematically optimizing key parameters such as the amount of sorbent, extraction time, and sample volume, optimal conditions to achieve maximum extraction efficiency were obtained. They were determined to be 30 mg of sorbent, 15 min extraction time, and 15 mL sample volume. The method achieved excellent linearity, with the coefficient of determination (R2) of 0.9985 for TC and 0.9789 for BPA. Depending on the analyte, the LOD and LOQ ranged from 2.41 - 2.57 µg L-1 and 6.7 - 8.6 µg L-1. Subsequently, the developed method was successfully applied in the analysis of tap water samples, yielding relative recoveries ranging from 80.2 - 97.5% for TC and 86.2 - 100.5% for BPA, highlighting this method has its potential as a rapid, selective, and straightforward extraction method most suitable for routine water sampling analysis. © 2024 Malaysian Institute of Chemistry. All rights reserved.