A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma

Introduction: The MERIT study in Malaysia is a real-world retrospective, observational, multicenter study that evaluated asthma control in patients with uncontrolled asthma who were switched from as-needed (pro re nata [PRN]) budesonide/formoterol or inhaled corticosteroid (ICS) whenever a short-act...

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Published in:Pulmonary Therapy
Main Author: Ismail A.I.; Hyder Ali I.A.; Wong C.K.; Ban A.Y.-L.; MZ Zahrah F.; Lem L.K.; Abu Bakar Z.; Alaga A.; Omar A.; Samsudin A.; Lai S.L.; Gandhi A.
Format: Article
Language:English
Published: Adis 2024
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208806162&doi=10.1007%2fs41030-024-00278-8&partnerID=40&md5=c1d4417fca2e39a0e44beca69e4a0ae7
id 2-s2.0-85208806162
spelling 2-s2.0-85208806162
Ismail A.I.; Hyder Ali I.A.; Wong C.K.; Ban A.Y.-L.; MZ Zahrah F.; Lem L.K.; Abu Bakar Z.; Alaga A.; Omar A.; Samsudin A.; Lai S.L.; Gandhi A.
A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma
2024
Pulmonary Therapy


10.1007/s41030-024-00278-8
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208806162&doi=10.1007%2fs41030-024-00278-8&partnerID=40&md5=c1d4417fca2e39a0e44beca69e4a0ae7
Introduction: The MERIT study in Malaysia is a real-world retrospective, observational, multicenter study that evaluated asthma control in patients with uncontrolled asthma who were switched from as-needed (pro re nata [PRN]) budesonide/formoterol or inhaled corticosteroid (ICS) whenever a short-acting beta-agonist (SABA) was taken, to proactive regular dosing of fluticasone propionate/salmeterol (FP/SAL PRD). Methods: Data from the medical records of patients who were stepped up to FP/SAL PRD were extracted retrospectively at baseline and follow-up (between 3 and 6 months after stepping up to FP/SAL PRD). The primary endpoint was the percentage of patients with improvement in asthma control assessed via the Asthma Control Test (ACT). Secondary endpoints included safety and the percentage of patients with moderate and severe exacerbations. Additionally, patient-reported use of reliever medication, systemic corticosteroids, emergency department visits, or hospitalization was also analyzed. Results: One hundred twenty patients with uncontrolled asthma who were stepped up to FP/SAL PRD were enrolled in the study. Of these, 76 (63.3%) patients were on prior budesonide/formoterol PRN, and 44 (36.7%) were on prior ICS with SABA PRN treatment. After stepping up to FP/SAL PRD with a mean follow-up of 5.8 months, 110 (91.7%) patients achieved asthma control at the follow-up visit (p < 0.001). Similar improvements were observed regardless of prior PRN regimen. A statistically significant improvement was observed in the mean ACT score at the follow-up visit (p < 0.0001). The proportion of patients with moderate and severe exacerbations was also reduced after stepping up to FP/SAL PRD, with no adverse events reported. Over 80% of patients reported a decrease in the use of systemic corticosteroids, visits to the emergency department, or hospitalization. Conclusion: This study highlights the effectiveness of the FP/SAL PRD treatment approach in patients with uncontrolled asthma on a PRN treatment regimen. © The Author(s) 2024.
Adis
23641754
English
Article
All Open Access; Gold Open Access
author Ismail A.I.; Hyder Ali I.A.; Wong C.K.; Ban A.Y.-L.; MZ Zahrah F.; Lem L.K.; Abu Bakar Z.; Alaga A.; Omar A.; Samsudin A.; Lai S.L.; Gandhi A.
spellingShingle Ismail A.I.; Hyder Ali I.A.; Wong C.K.; Ban A.Y.-L.; MZ Zahrah F.; Lem L.K.; Abu Bakar Z.; Alaga A.; Omar A.; Samsudin A.; Lai S.L.; Gandhi A.
A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma
author_facet Ismail A.I.; Hyder Ali I.A.; Wong C.K.; Ban A.Y.-L.; MZ Zahrah F.; Lem L.K.; Abu Bakar Z.; Alaga A.; Omar A.; Samsudin A.; Lai S.L.; Gandhi A.
author_sort Ismail A.I.; Hyder Ali I.A.; Wong C.K.; Ban A.Y.-L.; MZ Zahrah F.; Lem L.K.; Abu Bakar Z.; Alaga A.; Omar A.; Samsudin A.; Lai S.L.; Gandhi A.
title A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma
title_short A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma
title_full A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma
title_fullStr A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma
title_full_unstemmed A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma
title_sort A Retrospective Study Evaluating Asthma Control in Patients on Fluticasone Propionate/Salmeterol Proactive Regular Dosing with a History of Uncontrolled Asthma
publishDate 2024
container_title Pulmonary Therapy
container_volume
container_issue
doi_str_mv 10.1007/s41030-024-00278-8
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208806162&doi=10.1007%2fs41030-024-00278-8&partnerID=40&md5=c1d4417fca2e39a0e44beca69e4a0ae7
description Introduction: The MERIT study in Malaysia is a real-world retrospective, observational, multicenter study that evaluated asthma control in patients with uncontrolled asthma who were switched from as-needed (pro re nata [PRN]) budesonide/formoterol or inhaled corticosteroid (ICS) whenever a short-acting beta-agonist (SABA) was taken, to proactive regular dosing of fluticasone propionate/salmeterol (FP/SAL PRD). Methods: Data from the medical records of patients who were stepped up to FP/SAL PRD were extracted retrospectively at baseline and follow-up (between 3 and 6 months after stepping up to FP/SAL PRD). The primary endpoint was the percentage of patients with improvement in asthma control assessed via the Asthma Control Test (ACT). Secondary endpoints included safety and the percentage of patients with moderate and severe exacerbations. Additionally, patient-reported use of reliever medication, systemic corticosteroids, emergency department visits, or hospitalization was also analyzed. Results: One hundred twenty patients with uncontrolled asthma who were stepped up to FP/SAL PRD were enrolled in the study. Of these, 76 (63.3%) patients were on prior budesonide/formoterol PRN, and 44 (36.7%) were on prior ICS with SABA PRN treatment. After stepping up to FP/SAL PRD with a mean follow-up of 5.8 months, 110 (91.7%) patients achieved asthma control at the follow-up visit (p < 0.001). Similar improvements were observed regardless of prior PRN regimen. A statistically significant improvement was observed in the mean ACT score at the follow-up visit (p < 0.0001). The proportion of patients with moderate and severe exacerbations was also reduced after stepping up to FP/SAL PRD, with no adverse events reported. Over 80% of patients reported a decrease in the use of systemic corticosteroids, visits to the emergency department, or hospitalization. Conclusion: This study highlights the effectiveness of the FP/SAL PRD treatment approach in patients with uncontrolled asthma on a PRN treatment regimen. © The Author(s) 2024.
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