Anti-inflammatory Activity of 1-Substituted Glyoxal β-Carboline Derivatives

• Published in: Malaysian Journal of Fundamental and Applied Sciences
• Main Author: Zulkifli S.Z.; Asha'ari N.A.N.; Aziz A.F.A.; Pungot N.H.
• Format: Article
• Language: English
• Published: Penerbit UTM Press 2024
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208408039&doi=10.11113%2fmjfas.v20n5.3630&partnerID=40&md5=7c3304c6812269980131d2c5e3267c2c

The anti-inflammatory properties of β-carbolines have been widely studied, highlighting their potential in treating inflammatory disorders. This research investigates the anti-inflammatory activity of selected 1-substituted glyoxal β-carboline derivatives, achieved through a one-step conversion of 5-hydroxy-L-tryptophan with activated glyoxal, without forming tetrahydroβ-carboline (THβC) intermediates. These derivatives (4e-g) were synthesized successfully without requiring expensive metal catalysts, prolonged reaction times, or stringent reaction conditions, and yielded moderate amounts. Our findings indicate that all the derivatives significantly inhibit xanthine oxidase (XO) activity, leading to a reduction in reactive oxygen species (ROS) and free radicals. This inhibition disrupts the inflammatory cascade and attenuates the inflammatory response. ©Copyright Zulkifli.