Biotransformation of steroids: Accelerating discovery of new drugs in the pharmaceutical industry

Natural products account for 60% of the total market, making them a major source of drug discovery. Some of these are sourced from the cultivation of microorganisms. Microbial transformation is an example of the application of the cultivation of microorganisms. It is a method of modifying the chemic...

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Bibliographic Details
Published in:Steroids and their Medicinal Potential
Main Author: Sultan S.; Singh G.K.S.; Ashraf K.; Ashraf M.
Format: Book chapter
Language:English
Published: Bentham Science Publishers 2023
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85205743367&partnerID=40&md5=a5382708001b7d92db55902fcbc30596
id 2-s2.0-85205743367
spelling 2-s2.0-85205743367
Sultan S.; Singh G.K.S.; Ashraf K.; Ashraf M.
Biotransformation of steroids: Accelerating discovery of new drugs in the pharmaceutical industry
2023
Steroids and their Medicinal Potential



https://www.scopus.com/inward/record.uri?eid=2-s2.0-85205743367&partnerID=40&md5=a5382708001b7d92db55902fcbc30596
Natural products account for 60% of the total market, making them a major source of drug discovery. Some of these are sourced from the cultivation of microorganisms. Microbial transformation is an example of the application of the cultivation of microorganisms. It is a method of modifying the chemical structure of compounds such as steroids by microorganisms. The diversity of the possible reaction types in microbial transformation includes the process of oxidation, hydroxylation, esterification, isomerization, reduction, acetylation, hydrogenation and glycosylation. Therefore, screening of new microbial strains for specific bioconversions is essential for bioprospecting. This chapter reviews a range of previous studies that have used fungi for biotransformation. © 2023 Bentham Science Publishers. All rights reserved.
Bentham Science Publishers

English
Book chapter

author Sultan S.; Singh G.K.S.; Ashraf K.; Ashraf M.
spellingShingle Sultan S.; Singh G.K.S.; Ashraf K.; Ashraf M.
Biotransformation of steroids: Accelerating discovery of new drugs in the pharmaceutical industry
author_facet Sultan S.; Singh G.K.S.; Ashraf K.; Ashraf M.
author_sort Sultan S.; Singh G.K.S.; Ashraf K.; Ashraf M.
title Biotransformation of steroids: Accelerating discovery of new drugs in the pharmaceutical industry
title_short Biotransformation of steroids: Accelerating discovery of new drugs in the pharmaceutical industry
title_full Biotransformation of steroids: Accelerating discovery of new drugs in the pharmaceutical industry
title_fullStr Biotransformation of steroids: Accelerating discovery of new drugs in the pharmaceutical industry
title_full_unstemmed Biotransformation of steroids: Accelerating discovery of new drugs in the pharmaceutical industry
title_sort Biotransformation of steroids: Accelerating discovery of new drugs in the pharmaceutical industry
publishDate 2023
container_title Steroids and their Medicinal Potential
container_volume
container_issue
doi_str_mv
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85205743367&partnerID=40&md5=a5382708001b7d92db55902fcbc30596
description Natural products account for 60% of the total market, making them a major source of drug discovery. Some of these are sourced from the cultivation of microorganisms. Microbial transformation is an example of the application of the cultivation of microorganisms. It is a method of modifying the chemical structure of compounds such as steroids by microorganisms. The diversity of the possible reaction types in microbial transformation includes the process of oxidation, hydroxylation, esterification, isomerization, reduction, acetylation, hydrogenation and glycosylation. Therefore, screening of new microbial strains for specific bioconversions is essential for bioprospecting. This chapter reviews a range of previous studies that have used fungi for biotransformation. © 2023 Bentham Science Publishers. All rights reserved.
publisher Bentham Science Publishers
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language English
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