Synthesis, characterization, in-vitro and in-silico therapeutic studies of cinnamaldehyde derivatives

QR Code

Synthesis, characterization, in-vitro and in-silico therapeutic studies of cinnamaldehyde derivatives

Cinnamomum verum (cinnamon) is a versatile spice belonging to the family Lauraceae. The plant is widely used for its various therapeutic potential viz. antimicrobial, antioxidant, anti-inflammatory, anti-diabetic, anticancer, etc. Its phytocompounds render these therapeutic efficacies of cinnamon. C...

Full description

Bibliographic Details
Published in:	Journal of Molecular Structure
Main Author:	Singh N.; Yadav S.S.; Kumar S.; Narasihman B.; Ramasamy K.; Lim S.M.; Shah S.A.A.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2025
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85204950204&doi=10.1016%2fj.molstruc.2024.140165&partnerID=40&md5=04130461a72cd1716d25b44464ca6968

Similar Items

Synthesis, characterization, in-vitro and in-silico therapeutic studies of cinnamaldehyde derivatives
by: Singh, et al.
Published: (2025)

Synthesis of azomethines derived from cinnamaldehyde and vanillin: in vitro aetylcholinesterase inhibitory, antioxidant and insilico molecular docking studies
by: Chigurupati S.; Selvaraj M.; Mani V.; Mohammad J.I.; Selvarajan K.K.; Akhtar S.S.; Marikannan M.; Raj S.; Teh L.K.; Salleh M.Z.
Published: (2018)

In vitro antioxidant and in vivo antidepressant activity of green synthesized azomethine derivatives of cinnamaldehyde
by: Chigurupati S.; Shaikh S.; Mohammad J.; Selvarajan K.; Nemala A.; Khaw C.; Teoh C.; Kee T.
Published: (2017)

Design, synthesis and therapeutic potential of some 6, 6'-(1,4- phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)analogues
by: Kumar S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Published: (2019)

Synthesis, characterization, biological evaluation and molecular docking studies of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides
by: Yadav S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Selvaraj M.
Published: (2017)

Synthesis and in silico study of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives as suitable therapeutic agents
by: Hussain G.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Qurat-ul-Ain; Ahmad I.; Malik R.; Lodhi M.A.; Khan F.A.; Shahid M.; Fatima H.
Published: (2017)

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach
by: Ullah N.; Alam A.; Zainab; Elhenawy A.A.; Naz S.; Islam M.S.; Ahmad S.; Shah S.A.A.; Ahmad M.
Published: (2024)

In-silico molecular design of heterocyclic benzimidazole scaffolds as prospective anticancer agents
by: Tahlan S.; Kumar S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2019)

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives
by: Kumar S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Selvaraj M.; Narasimhan B.
Published: (2017)

Design, synthesis and therapeutic potential of 3-(2-(1H-benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamide analogues
by: Tahlan S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2018)

Discovery of imidazopyridine derived oxadiazole-based thiourea derivatives as potential anti-diabetic agents: Synthesis, in vitro antioxidant screening and in silico molecular modeling approaches
by: Hussain R.; Rehman W.; Rahim F.; Khan S.; Taha M.; Khan Y.; Sardar A.; Khan I.; Shah S.A.A.
Published: (2023)

New thiazole-based thiazolidinone derivatives: Synthesis, in vitro α-amylase, α-glucosidase activities and silico molecular docking study
by: Khan S.; Ullah H.; Rahim F.; Taha M.; Hussain R.; Khan M.S.; Ali H.; Khan M.U.; Shah S.A.A.; Khan K.M.
Published: (2022)

Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights
by: Alam A.; Gul S.; Zainab; Khan M.; Elhenawy A.A.; Islam M.S.; Ali M.; Ali Shah S.A.; Latif A.; Ahmad M.
Published: (2024)

Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
by: Kakkar S.; Kumar S.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.; Narasimhan B.
Published: (2018)

Benzoxazole derivatives: design, synthesis and biological evaluation
by: Kakkar S.; Tahlan S.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.; Narasimhan B.
Published: (2018)

4-(4-Bromophenyl)-Thiazol-2-Amine derivatives: Synthesis, biological activity and molecular docking study with ADME profile
by: Sharma D.; Kumar S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.
Published: (2019)

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives
by: Kumar S.; Singh J.; Narasimhan B.; Shah S.A.A.; Lim S.M.; Ramasamy K.; Mani V.
Published: (2018)

Design, synthesis, antimicrobial and cytotoxicity study on human colorectal carcinoma cell line of new 4,4′-(1,4-phenylene) bis(pyrimidin-2-amine) derivatives
by: Kumar S.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.; Narasimhan B.
Published: (2018)

Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamides
by: Yadav S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Mathur A.; Narasimhan B.
Published: (2018)

Synthesis, in vitro antiurease, in vivo antinematodal activity of quinoline analogs and their in-silico study
by: Zaman K.; Rahim F.; Taha M.; Sajid M.; Hayat S.; Nawaz M.; Salahuddin M.; Iqbal N.; Khan N.U.; Shah S.A.A.; Farooq R.K.; Bahadar A.; Wadood A.; Khan K.M.
Published: (2021)

Synthesis, in vitro α-glucosidase activity and in silico molecular docking study of isatin analogues
by: Ullah H.; Rahim F.; Ullah E.; Hayat S.; Zada H.; Khan F.; Wadood A.; Nawaz F.; Rehman Z.U.; Shah S.A.A.
Published: (2023)

Synthesis, molecular modelling and biological significance of N-(4-(4-bromophenyl) thiazol-2-yl)-2-chloroacetamide derivatives as prospective antimicrobial and antiproliferative agents
by: Sharma D.; Kumar S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.
Published: (2019)

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach
by: Ullah, et al.
Published: (2024)

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach
by: Ullah, et al.
Published: (2024)

Synthesis of modified 1,3,4-thiadiazole incorporating substituted thiosemicarbazide derivatives: Elucidating the in vitro and in silico studies to develop promising anti-diabetic agent
by: Abbasi S.A.; Rahim F.; Hussain R.; Khan S.; Ullah H.; Iqbal T.; Iqbal N.; Khan H.U.; Khan S.; Iqbal R.; Shah S.A.A.; Al Obaid S.; Ansari M.J.
Published: (2024)

Synthesis and biological profile of substituted benzimidazoles
by: Vashist N.; Sambi S.S.; Narasimhan B.; Kumar S.; Lim S.M.; Shah S.A.A.; Ramasamy K.; Mani V.
Published: (2018)

Design, synthesis, sar study, antimicrobial and anticancer evaluation of novel 2-mercaptobenzimidazole azomethine derivatives
by: Tahlan S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Published: (2020)

Synthesis, anti-diabetic and in silico QSAR analysis of flavone hydrazide Schiff base derivatives
by: Jamil W.; Shaikh J.; Yousuf M.; Taha M.; Khan K.M.; Shah S.A.A.
Published: (2022)

Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening
by: Ahmad S.N.; Bahron H.; Tajuddin A.M.; Ramasamy K.
Published: (2019)

2-Furoic piperazide derivatives as promising drug candidates of type 2 diabetes and Alzheimer's diseases: In vitro and in silico studies
by: Abbasi M.A.; Hassan M.; ur-Rehman A.; Siddiqui S.Z.; Hussain G.; Shah S.A.A.; Ashraf M.; Shahid M.; Seo S.Y.
Published: (2018)

Hydrazinyl arylthiazole based pyridine scaffolds: Synthesis, structural characterization, in vitro α-glucosidase inhibitory activity, and in silico studies
by: Ali F.; Khan K.M.; Salar U.; Taha M.; Ismail N.H.; Wadood A.; Riaz M.; Perveen S.
Published: (2017)

Therapeutic potentials of iridoids derived from Rubiaceae against in vitro and in vivo inflammation: A scoping review
by: Jaafar A.; Zulkipli M.A.; Mohd Hatta F.H.; Jahidin A.H.; Abdul Nasir N.A.; Hazizul Hasan M.
Published: (2024)

Therapeutic potentials of iridoids derived from Rubiaceae against in vitro and in vivo inflammation: A scoping review
by: Jaafar, et al.
Published: (2024)

Bis-pyrimidine acetamides: Design, synthesis and biological evaluation
by: Kumar S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Narasimhan B.
Published: (2017)

Polymeric and non-polymeric nanofiber of Cinnamaldehyde from Cinnamon oil (Cinnamomum zeylanicum)
by: Moreta S.; Cahyono E.; Affandi N.D.N.; Fadil F.; Kurniawan C.
Published: (2020)

Synthesis and in vitro study of benzofuran hydrazone derivatives as novel alpha-amylase inhibitor
by: Taha M.; Shah S.A.A.; Imran S.; Afifi M.; Chigurupati S.; Selvaraj M.; Rahim F.; Ullah H.; Zaman K.; Vijayabalan S.
Published: (2017)

In Vitro and In Silico Investigation of Diterpenoid Alkaloids Isolated from Delphinium chitralense
by: Ahmad S.; Ahmad M.; Almehmadi M.; Shah S.A.A.; Khan F.A.; Khan N.M.; Khan A.; Zainab; Halawi M.; Ahmad H.
Published: (2022)

In vitro antioxidant and in silico enzyme inhibition studies of Carissa carandas Linn.: potential ingredient for nutraceutical development
by: Zubair M.; Tousif M.I.; Riaz N.; Saleem M.; Nazir M.; Tauseef S.; Hassan A.; Shah S.A.A.; Zengin G.; Hashem A.; Kumar A.; Abd_Allah E.F.
Published: (2024)

Design, synthesis and biological potential of heterocyclic benzoxazole scaffolds as promising antimicrobial and anticancer agents
by: Kakkar S.; Kumar S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Published: (2018)

Unveiling the Biomedical Applications of Zinc Oxide (ZnO) Nanoparticles: A Review Fostering on the Synthesis, Therapeutics and Imaging with Recent Developments
by: Cheng, et al.
Published: (2024)