Exploring Acyl Thiotriazinoindole Based Pharmacophores: Design, Synthesis, and SAR Studies with Molecular Docking and Biological Activity Profiling against Urease, α-amylase, α-glucosidase, Antimicrobial, and Antioxidant Targets

QR Code

Exploring Acyl Thiotriazinoindole Based Pharmacophores: Design, Synthesis, and SAR Studies with Molecular Docking and Biological Activity Profiling against Urease, α-amylase, α-glucosidase, Antimicrobial, and Antioxidant Targets

A diminutive chemical library of acyl thiotriazinoindole (ATTI) based bioactive scaffolds was synthesized, instigated by taking the economical starting material Isatin, through a series of five steps. Isatin was first nitrated followed by the attachment of pentyl moiety via nucleophilic substitution...

Full description

Bibliographic Details
Published in:	Protein Journal
Main Author:	Haider M.B.; Saeed A.; Ahmed A.; Azeem M.; Ismail H.; Mehmood S.; Taslimi P.; Shah S.A.A.; Irfan M.; El-Seedi H.R.
Format:	Article
Language:	English
Published:	Springer 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85202972638&doi=10.1007%2fs10930-024-10229-6&partnerID=40&md5=fb9f13651dd7dd8aa429c4b81bb5a77d

Similar Items

Exploring Acyl Thiotriazinoindole Based Pharmacophores: Design, Synthesis, and SAR Studies with Molecular Docking and Biological Activity Profiling against Urease, α-amylase, α-glucosidase, Antimicrobial, and Antioxidant Targets
by: Haider, et al.
Published: (2024)

Novel acyl hydrazide derivatives of polyhydroquinoline as potent anti-diabetic and anti-glycating agents: Synthesis, in vitro α-amylase, α-glucosidase inhibition and anti-glycating activity with molecular docking insights
by: Ur Rahman S.; Alam A.; Parveen Z.; Zainab; Assad M.; Adnan Ali Shah S.; Rafiq H.; Ayaz M.; Latif A.; Naveed Umar M.; Ali M.; Ahmad M.
Published: (2024)

Synthesis of new arylhydrazide bearing Schiff bases/thiazolidinone: α-Amylase, urease activities and their molecular docking studies
by: Rahim F.; Taha M.; Ullah H.; Wadood A.; Selvaraj M.; Rab A.; Sajid M.; Shah S.A.A.; Uddin N.; Gollapalli M.
Published: (2019)

Synthesis of Indole Based Sulfonamide Derivatives as potent inhibitors of α-glucosidase and α-amylase in management of type-II diabetes
by: Ullah W.; Rahim F.; Hayat S.; Ullah H.; Taha M.; Khan S.; Khaliq A.; Bibi S.; Gohar O.; Iqbal N.; Shah S.A.A.; Khan K.M.
Published: (2024)

New thiazole-based thiazolidinone derivatives: Synthesis, in vitro α-amylase, α-glucosidase activities and silico molecular docking study
by: Khan S.; Ullah H.; Rahim F.; Taha M.; Hussain R.; Khan M.S.; Ali H.; Khan M.U.; Shah S.A.A.; Khan K.M.
Published: (2022)

New biologically dynamic hybrid pharmacophore triazinoindole-based-thiadiazole as potent α-glucosidase inhibitors: In vitro and in silico study
by: Khan A.A.; Rahim F.; Taha M.; Rehman W.; Iqbal N.; Wadood A.; Ahmad N.; Shah S.A.A.; Ghoneim M.M.; Alshehri S.; Salahuddin M.; Khan K.M.
Published: (2022)

Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study
by: Ullah H.; Khan S.; Rahim F.; Taha M.; Iqbal R.; Sarfraz M.; Shah S.A.A.; Sajid M.; Awad M.F.; Omran A.; Albalawi M.A.; Abdelaziz M.A.; Al Areefy A.; Jafri I.
Published: (2022)

New benzoxazole-based sulphonamide hybrids analogs as potent inhibitors of α-amylase and α-glucosidase: Synthesis and in vitro evaluation along with in silico study
by: Khan S.; Rahim F.; Rehman W.; Nawaz M.; Taha M.; Fazil S.; Hussain R.; Adnan Ali Shah S.; Abdellatif M.H.
Published: (2022)

Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential
by: Taha M.; Ismail N.H.; Baharudin M.S.; Lalani S.; Mehboob S.; Khan K.M.; Yousuf S.; Siddiqui S.; Rahim F.; Choudhary M.I.
Published: (2015)

Molecular Modeling and Synthesis of Indoline-2,3-dione-Based Benzene Sulfonamide Derivatives and Their Inhibitory Activity against α-Glucosidase and α-Amylase Enzymes
by: Rasheed L.; Rehman W.; Rahim F.; Ali Z.; Alanazi A.S.; Hussain R.; Khan I.; Alanazi M.M.; Naseer M.; Abdellattif M.H.; Hussain R.; Khan S.; Taha M.; Ali Shah S.A.
Published: (2023)

Synthesis and biological evaluation of indole derivatives as α-amylase inhibitor
by: Imran S.; Taha M.; Selvaraj M.; Ismail N.H.; Chigurupati S.; Mohammad J.I.
Published: (2017)

Purification and characterisation of thermostable α-amylases from microbial sources
by: Lim S.J.; Hazwani-Oslan S.N.; Oslan S.N.
Published: (2020)

Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: Elucidating the in vitro and in silico α-amylase and α-glucosidase inhibitors potential
by: Abbasi S.A.; Rahim F.; Hussain R.; Rehman W.; Khan S.; Taha M.; Iqbal T.; Khan Y.; Ali Shah S.A.
Published: (2024)

Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: elucidating the in vitro and in silico α-amylase and α-glucosidase inhibitors potential
by: Abbasi, et al.
Published: (2024)

Novel quinoline derivatives as potent in vitro α-glucosidase inhibitors: In silico studies and SAR predictions
by: Taha M.; Ismail N.H.; Imran S.; Wadood A.; Rahim F.; Ali M.; Rehman A.U.
Published: (2015)

Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives
by: Taha M.; Tariq Javid M.; Imran S.; Selvaraj M.; Chigurupati S.; Ullah H.; Rahim F.; Khan F.; Islam Mohammad J.; Mohammed Khan K.
Published: (2017)

Synthesis, α-amylase inhibition and molecular docking study of bisindolylmethane sulfonamide derivatives
by: Taha M.; Noreen T.; Imran S.; Nawaz F.; Chigurupati S.; Selvaraj M.; Rahim F.; Hadiani Ismail N.; Kumar A.; Mosaddik A.; Alghamdi A.M.; Abdulrahman nasser alqahtani Y.; Abdulrahman nasser alqahtani A.
Published: (2019)

Synthesis, α-amylase inhibitory potential and molecular docking study of indole derivatives
by: Taha M.; Baharudin M.S.; Ismail N.H.; Imran S.; Khan M.N.; Rahim F.; Selvaraj M.; Chigurupati S.; Nawaz M.; Qureshi F.; Vijayabalan S.
Published: (2018)

Thiazole based carbohydrazide derivatives as α-amylase inhibitor and their molecular docking study
by: Taha M.; Irshad M.; Imran S.; Rahim F.; Selvaraj M.; Almandil N.B.; Mosaddik A.; Chigurupati S.; Nawaz F.; Ismail N.H.; Ibrahim M.
Published: (2019)

Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase
by: Taha M.; Khan A.A.; Rahim F.; Hayat S.; Imran S.; Iqbal N.; Uddin N.; Khan K.M.; Anouar E.H.; Farooq R.K.; Nawaz M.; Shah S.A.A.
Published: (2023)

Synthesis of 2-acylated and sulfonated 4-hydroxycoumarins: In vitro urease inhibition and molecular docking studies
by: Rashid U.; Rahim F.; Taha M.; Arshad M.; Ullah H.; Mahmood T.; Ali M.
Published: (2016)

Synthesis, In Vitro α-Amylase Activity, and Molecular Docking Study of New Benzimidazole Derivatives
by: Ullah H.; Ullah H.; Taha M.; Khan F.; Rahim F.; Uddin I.; Sarfraz M.; Shah S.A.A.; Aziz A.; Mubeen S.
Published: (2021)

5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of α-glucosidase and urease enzymes
by: Arshad T.; Khan K.M.; Rasool N.; Salar U.; Hussain S.; Asghar H.; Ashraf M.; Wadood A.; Riaz M.; Perveen S.; Taha M.; Ismail N.H.
Published: (2017)

Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase
by: Rahim F.; Ullah H.; Javid M.T.; Wadood A.; Taha M.; Ashraf M.; Shaukat A.; Junaid M.; Hussain S.; Rehman W.; Mehmood R.; Sajid M.; Khan M.N.; Khan K.M.
Published: (2015)

Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes
by: Hussain S.; Taha M.; Rahim F.; Hayat S.; Zaman K.; Iqbal N.; Selvaraj M.; Sajid M.; Bangesh M.A.; Khan F.; Khan K.M.; Uddin N.; Shah S.A.A.; Ali M.
Published: (2021)

New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking study
by: Rahim F.; Tariq S.; Taha M.; Ullah H.; Zaman K.; Uddin I.; Wadood A.; Khan A.A.; Rehman A.U.; Uddin N.; Zafar S.; Shah S.A.A.
Published: (2019)

Synthesis of new oxadiazole derivatives as α-glucosidase inhibitors
by: Taha M.; Ismail N.H.; Imran S.; Rokei M.Q.B.; Saad S.M.; Khan K.M.
Published: (2015)

α-Glucosidase inhibition of lactone intermediates of the iminosugar deoxynojirimycin
by: Haan Y.W.; Al-Bajalan H.M.; Sage E.E.; Elangovan D.; Yajit N.L.M.; Sarizan N.M.; Zitzmann N.; Kiappes J.L.; Hasbullah S.A.; Ismail N.H.; Mackeen M.M.
Published: (2019)

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives
by: Kumar S.; Singh J.; Narasimhan B.; Shah S.A.A.; Lim S.M.; Ramasamy K.; Mani V.
Published: (2018)

Benzimidazole derivatives as new α-glucosidase inhibitors and in silico studies
by: Zawawi N.K.N.A.; Taha M.; Ahmat N.; Wadood A.; Ismail N.H.; Rahim F.; Azam S.S.; Abdullah N.
Published: (2016)

Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles
by: Yu C.X.; Tan J.W.; Rullah K.; Imran S.; Tham C.L.
Published: (2023)

Erratum: Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential (Medicinal Chemistry Research (DOI 10.1007/s00044-014-1213-8))
by: Taha M.; Ismail N.H.; Baharudin M.S.; Lalani S.; Mehboob S.; Khan K.M.; Yousuf S.; Siddiqui S.; Rahim F.; Choudhary M.I.
Published: (2015)

Oxindole based oxadiazole hybrid analogs: Novel α-glucosidase inhibitors
by: Taha M.; Imran S.; Rahim F.; Wadood A.; Khan K.M.
Published: (2018)

Synthesis, molecular docking studies of hybrid benzimidazole as α-glucosidase inhibitor
by: Zawawi N.K.N.A.; Taha M.; Ahmat N.; Ismail N.H.; Wadood A.; Rahim F.
Published: (2017)

Antioxidant and α-glucosidase inhibitory constituents from Hornstedtia species of Malaysia
by: Hashim S.E.; Sirat H.M.; Yen K.H.; Ismail I.S.; Matsuki S.N.
Published: (2015)

Synthesis of Bis-indolylmethane sulfonohydrazides derivatives as potent α-Glucosidase inhibitors
by: Gollapalli M.; Taha M.; Ullah H.; Nawaz M.; AlMuqarrabun L.M.R.; Rahim F.; Qureshi F.; Mosaddik A.; Ahmat N.; Khan K.M.
Published: (2018)

Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives
by: Taha M.; Shah S.A.A.; Afifi M.; Imran S.; Sultan S.; Rahim F.; Khan K.M.
Published: (2018)

Biscoumarin analogs: Synthesis, α-glucosidase inhibitory potential and molecular docking study
by: Ahmat N.; Nik Abdullah Zawawi N.K.; Taha M.; Wadood A.; Rahim F.; Ullah H.
Published: (2020)

Synthesis, in vitro and Docking Studies of New Flavone Ethers as α-Glucosidase Inhibitors
by: Imran S.; Taha M.; Ismail N.H.; Kashif S.M.; Rahim F.; Jamil W.; Wahab H.; Khan K.M.
Published: (2016)

Synthesis, biological activity and molecular docking of new tricyclic series as α-glucosidase inhibitors
by: Abuelizz H.A.; Iwana N.A.N.I.; Ahmad R.; Anouar E.-H.; Marzouk M.; Al-Salahi R.
Published: (2019)