| Summary: | The rise in bacterial resistance to antibiotics necessitates the development of new antimicrobials. Pathogenic microorganisms from hospitals, communities, and environments pose significant health risks exacerbated by the uncontrolled use of antibiotics, highlighting the urgent need for innovative solutions. To address antibiotic resistance, analysed the antimicrobial activity of Bacillus subtilis, Staphylococcus aureus, and Streptococcus pyogenes using biochemical assays with some antibiotics: tetracycline, erythromycin, trimethoprim, rifampicin, hygromycin, and streptomycin. The study employed agar diffusion and microtiter methods to assess antimicrobial efficacy. Results indicated that all bacterial cultures were sensitive to the antibiotics tested. Bacillus subtilis exhibited high susceptibility to tetracycline, erythromycin, hygromycin, and streptomycin, with moderate susceptibility to trimethoprim and rifampicin. S. aureus showed sensitivity to the same antibiotics but to a lesser extent than B. subtilis. S. pyogenes were also susceptible to tetracycline, erythromycin, hygromycin, and streptomycin. Notably, the non-pathogenic B. subtilis demonstrated greater antibiotic susceptibility than the pathogenic S. aureus and S. pyogenes. All three bacteria exhibited consistent antibiotic susceptibility, demonstrating inhibition zones for all seven antibiotics. This study aids in developing effective treatments for resistant bacteria, contributing to combating bacterial diseases. © 2024, Dr Tarak Nath Podder Memorial Foundation. All rights reserved.
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