Convergent synthesis, kinetics and computational attributions of indole-N-phenyltriazole hybrids bearing N-(aryl)butanamides as alkaline phosphatase inhibitors

QR Code

Convergent synthesis, kinetics and computational attributions of indole-N-phenyltriazole hybrids bearing N-(aryl)butanamides as alkaline phosphatase inhibitors

In the research delineate herein, an innovative sequence of new series of multi-functional target molecules (9a-i) having indole-N-phenyltriazole bi-heterocyclic hybrids unified with N-arylated butanamides was synthesized as alkaline phosphatase inhibitor. The structural validation of all the formul...

Full description

Bibliographic Details
Published in:	Journal of Molecular Structure
Main Author:	Shakila; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Nazir M.; Raza H.; Shah S.A.A.; Ayine-Tora D.M.; Shahid M.; Kim S.J.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2025
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85201787582&doi=10.1016%2fj.molstruc.2024.139649&partnerID=40&md5=226e3b1d8bc2d6570967dbc90f9e1377

Similar Items

2-Aminothiazole-Oxadiazole Bearing N-Arylated Butanamides: Convergent Synthesis, Tyrosinase Inhibition, Kinetics, Structure-Activity Relationship, and Binding Conformations
by: Raza H.; Rehman Sadiq Butt A.; Athar Abbasi M.; Aziz-ur-Rehman; Zahra Siddiqui S.; Hassan M.; Adnan Ali Shah S.; Ja Kim S.
Published: (2023)

Convergent synthesis, free radical scavenging, Lineweaver-Burk plot exploration, hemolysis and in silico study of novel indole-phenyltriazole hybrid bearing acetamides as potent urease inhibitors
by: Khan W.; Abbasi M.A.; Rehman A.-U.; Siddiqui S.Z.; Nazir M.; Ali Shah S.A.; Raza H.; Hassan M.; Shahid M.; Seo S.Y.
Published: (2020)

Convergent synthesis, kinetics insight and allosteric computational ascriptions of thiazole-(5-aryl)oxadiazole hybrids embraced with propanamides as alkaline phosphatase inhibitors
by: Butt A.R.S.; Abbasi M.A.; Aziz-Ur-Rehman N.; Siddiqui S.Z.; Muhammad S.; Raza H.; Shah S.A.A.; Shahid M.; Alsehemi A.G.; Kim S.J.
Published: (2023)

Multi-step synthesis of indole-N-ethyltriazole hybrids amalgamated with N-arylated ethanamides: structure-activity relationship and mechanistic explorations through tyrosinase inhibition, kinetics and computational ascriptions
by: Shakila; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Nazir M.; Raza H.; Zafar A.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Published: (2022)

Synthesis, In Vitro, and In Silico Studies of N-(Substituted-Phenyl)-3-(4-Phenyl-1-Piperazinyl)propanamides as Potent Alkaline Phosphatase Inhibitors
by: Abbasi M.A.; Nazir M.; Aziz-ur-Rehman; Siddiqui S.Z.; Raza H.; Zafar A.; Shah S.A.A.; Shahid M.
Published: (2021)

Novel indole based hybrid oxadiazole scaffolds with: N -(substituted-phenyl)butanamides: Synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors
by: Nazir M.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Raza H.; Hassan M.; Ali Shah S.A.; Shahid M.; Seo S.-Y.
Published: (2018)

Bi-heterocyclic benzamides as alkaline phosphatase inhibitors: Mechanistic comprehensions through kinetics and computational approaches
by: Abbasi M.A.; Nazir M.; ur-Rehman A.; Siddiqui S.Z.; Hassan M.; Raza H.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Published: (2019)

Synthesis, Kinetics and Computational Explorations of 4-Phenylpiperazine Bearing N-(Aryl)-3-substituted-benzamides as Auspicious Tyrosinase Inhibitors
by: Zeb A.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Hassan M.; Javed Q.; Rafiq M.; Ali A.; Shah S.A.A.; Kloczkowski A.
Published: (2024)

Synthesis, enzyme inhibitory kinetics, & computational studies of N-(substituted phenyl)-(5-(3,4-dichlorobenzyl)-4-(4-chlorophenyl)-4H-1,2,4-triazol-3-ylthio)methylbenzamides: As potent alkaline phosphatase inhibitors
by: Zeb A.; Siddiqui S.Z.; Abbasi M.A.; Aziz-ur-Rehman; Shah S.A.A.; Imran S.; Raza H.; Kim S.J.; Parveen R.; Abbas G.
Published: (2025)

Synthesis, enzyme inhibitory kinetics, & computational studies of N-(substituted phenyl)-(5-(3,4-dichlorobenzyl)-4-(4-chlorophenyl)-4H-1,2,4-triazol-3-ylthio)methylbenzamides: As potent alkaline phosphatase inhibitors
by: Zeb, et al.
Published: (2025)

Design, synthesis and computational studies of N-(substituted-phenyl)-4-(4-phenyl-1-piperazinyl)butanamides as potent anti-melanogenic and tyrosinase inhibitors
by: Raza H.; Abbasi M.A.; Rehman A.-U.; Siddiqui S.Z.; Hassan M.; Shah S.A.A.; Shahid M.; Hong H.; Seo S.-Y.
Published: (2020)

Design of potent tyrosinase inhibiting N-arylated-4-yl-benzamides bearing 2-aminothiazole-triazole bi-heterocycles: mechanistic insight through enzyme inhibition, kinetics and computational studies
by: Khan, et al.
Published: (2024)

Design of potent tyrosinase inhibiting N-arylated-4-yl-benzamides bearing 2-aminothiazole-triazole bi-heterocycles: mechanistic insight through enzyme inhibition, kinetics and computational studies
by: Khan F.M.; Abbasi M.A.; Rehman A.-U.; Siddiqui S.Z.; Sadiq Butt A.R.; Raza H.; Hassan M.; Ali Shah S.A.; Shahid M.; Kim S.J.
Published: (2024)

Synthesis, antimicrobial and cytotoxic evaluation of 4-(1-aryl-5-halo-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Narasimhan B.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2017)

Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Clercq E.D.; Narasimhan B.
Published: (2014)

Efficient Synthesis of 4-Bromo-N-(1-phenylethyl)benzamide, Arylation by Pd(0) Catalyst, Characterization and DFT Study
by: Raza Shah A.; Rasool N.; Bılal M.; Mubarık A.; Alı Hashmı M.; Nadeem Akhtar M.; Imran M.; Ahmad G.; Siddiqa A.; Adnan Alı Shah S.
Published: (2022)

4-(1-Aryl-5-chloro-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides: Synthesis, antimicrobial, anticancer evaluation and QSAR studies
by: Kumar M.; Narasimhan B.; Kumar P.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2014)

Synthesis, spectral analysis and biological evaluation of N-alkyl/aralkyl/aryl-4-chlorobenzenesulfonamide derivatives
by: Aziz-Ur-Rehman; Abbasi M.A.; Siddiqui S.Z.; Mohyuddin A.; Nadeem S.; Shah S.A.A.
Published: (2016)

Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
by: Shakila; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Nazir M.; Muhammad S.; Raza H.; Shah S.A.A.; Shahid M.; Chaudhry A.R.; Kim S.J.
Published: (2025)

Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches
by: Raza H.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Hassan M.; Abbas Q.; Hong H.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Published: (2020)

Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
by: Shakila; Abbasi, et al.
Published: (2025)

Synthesis, pharmacological screening & computational analysis of some 2-(1H-Indol-3-yl)-N'-[(un)substituted phenylmethylidene] acetohydrazides & 2-(1H-Indol-3-yl)-N'-[(un)substituted benzoyl/2-Thienylcarbonyl]acetohydrazides
by: Rubab K.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Qurat-Ul-Ain; Ahmad I.; Lodhi M.A.; Ghufran M.; Shahid M.; Fatima H.
Published: (2017)

Synthesis, Pharmacological Evaluation and Molecular Docking Studies of N-[2-(1H-indol-3-yl)Acetyl]Arylsulfonohydrazides
by: Rubab K.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Qurat-ul-Ain; Lodhi M.A.; Khan F.A.; Shahid M.; Fatima H.; Ahmad I.
Published: (2021)

Synthesis of some new 2-[4-(2-furoyl)-1-piperazinyl]-N-aryl/aralkyl acetamides as potent antibacterial agents
by: Hussain G.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Ali Shah S.A.; Ahmad I.; Shahid M.
Published: (2018)

Cytoprotective effect of benzyl N'-(5-Chloro-indol-3-ylmethylidene)- hydrazinecarbodithioate against ethanol-induced gastric mucosal injury in rats
by: Hashim H.; Mughrabi F.F.; Ameen M.; Khaledi H.; Ali H.M.
Published: (2012)

Synthesis of N-substituted acetamide derivatives of azinane-bearing 1,3,4-oxadiazole nucleus and screening for antibacterial activity
by: Iqbal K.; Jamal Q.; Iqbal J.; Afreen M.S.; Sandhu M.Z.A.; Dar E.; Farooq U.; Mushtaq M.F.; Arshad N.; Iqbal M.M.
Published: (2017)

Effects of n-methyl-n-nitrosourea on seed germination of Stevia rebaudiana
by: Ahmad L.W.Z.; Zainuddin Z.; Osman M.; Mohamad A.; Sidik N.J.
Published: (2019)

Role of GaN cap layer for reference electrode free AlGaN/GaN-based pH sensors
by: Parish G.; Khir F.L.M.; Krishnan N.R.; Wang J.; Krisjanto J.S.; Li H.; Umana-Membreno G.A.; Keller S.; Mishra U.K.; Baker M.V.; Nener B.D.; Myers M.
Published: (2019)

Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
by: Khan K.M.; Khan M.; Karim A.; Taha M.; Ambreen N.; Gojayev A.; Perveen S.; Choudhary M.I.
Published: (2013)

Are regional incomes in Malaysia converging?
by: Abdullah A.J.; Doucouliagos H.; Manning E.
Published: (2015)

Enhanced Breakdown Voltage of AlGaN/GaN MISHEMT using GaN Buffer with Carbon-Doping on Silicon for Power Device
by: Islam N.; Mohamed M.F.P.; Rahman S.F.A.; Syamsul M.; Kawarada H.; Rahim A.F.A.
Published: (2024)

Synthetic N-aralkylated-N-(2,4-dimethylphenyl)benzenesulfonamides: As potent anti-bacterial agents
by: Siddiqui S.Z.; Sarwar A.; Abbasi M.A.; Aziz-Ur-Rehman; Hussain M.; Irshad M.; Shah S.A.A.
Published: (2016)

XPS/NEXAFS spectroscopic and conductance studies of glycine on AlGaN/GaN transistor devices
by: Myers M.; Khir F.L.M.; Home M.A.; Mennell C.; Gillbanks J.; Tadich A.; Baker M.V.; Nener B.D.; Parish G.
Published: (2018)

Erratum: Cytoprotective effect of benzyl N'-(5-chloro-indol-3-yl- methylidene)hydrazinecarbodithioate against ethanol-induced gastric mucosal injury in rats (Molecules (2012) 17 (9306-9320))
by: Hashim H.
Published: (2013)

Chromatic classes of 2-connected (n, n + 4)-graphs with three triangles and one induced 4-cycle
by: Peng Y.H.; Lau G.C.
Published: (2009)

Analysis of the influence of the traps on the AlGaN/GaN MOSHEMT characteristics for low leakage power devices
by: Islam N.; Baharin M.S.N.S.; Rahim A.F.A.; Khan M.F.A.J.; Ghazali N.A.; Bakar A.S.A.; Mohamed M.F.P.
Published: (2024)

Physicochemical Properties of N,N-Diethylethanolammonium Chloride/Ethylene Glycol-Based Deep Eutectic Solvent for Replacement of Ionic Liquid
by: Fauzi R.; Daik R.; Fauzi B.; Mamauod S.N.L.
Published: (2023)

Synthesis of some new N-(alkyl/aralkyl)-N-(4-methoxyphenethyl) benzenesulfonamides as antibacterial agents against Escherichia coli
by: Abbasi M.A.; Fatima Z.; Aziz-Ur-Rehman; Siddiqui S.Z.; Ali Shah S.A.; Shahid M.; Fatima H.
Published: (2019)

GROWTH AND YIELD PERFORMANCE OF IPOMOEA BATATAS AS INFLUENCED BY N-(N-BUTYL) THIOPHOSPHATE TRIAMIDE (NBPT) COATED UREA (NCU)
by: Zulhilmi M.N.; Zaharah S.S.; Noraini M.J.; Khanif M.Y.
Published: (2022)

(E)-N'-(4-Chlorobenzylidene)-2-methoxybenzohydrazide
by: Baharudin M.S.; Taha M.; Ismail N.H.; Shah S.A.A.; Yousuf S.
Published: (2013)