Characteristics of calcified nodule attributable to culprit lesion in acute coronary syndrome: A systematic review and meta-analysis

• Published in: iScience
• Main Author: Kurniawan R.B.; Saputra P.B.T.; Haq A.U.D.U.; Purwati D.D.; Wungu C.D.K.; Susilo H.; Alsagaff M.Y.; Amin I.M.; Oktaviono Y.H.
• Format: Article
• Language: English
• Published: Elsevier Inc. 2024
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198161503&doi=10.1016%2fj.isci.2024.110351&partnerID=40&md5=9b811d37a69ca531905e45a10bbfe1a1
• ISSN: 25890042
• DOI: 10.1016/j.isci.2024.110351

The presence of calcified nodule (CN) is a significant characteristic of atherothrombosis in acute coronary syndrome (ACS). However, its characteristics continue to be understudied. This review aimed to further investigate these characteristics. This study found that CN was a distinctive feature of an atheromatous plaque, representing 6.3% of ACS. CN was more common in NSTE-ACS than in STEMI patients (9.4% vs. 6.6%). CN was also chiefly observed in the left anterior descendant artery (48%), followed by the right coronary (40.4%) and left circumflex (14.5%) arteries. Higher prevalence of hypertension (78.8%), diabetes mellitus (50.8%), multivessel disease (71.7%), and kidney disease (26.43%) were noted in CN compared to non-CN patients. CN-associated ACS also 6-fold increased the risk of target lesion revascularization compared to those without CN. © 2024 The Authors