Golgi apparatus targeted therapy in cancer: Are we there yet?

Membrane trafficking within the Golgi apparatus plays a pivotal role in the intracellular transportation of lipids and proteins. Dysregulation of this process can give rise to various pathological manifestations, including cancer. Exploiting Golgi defects, cancer cells capitalise on aberrant membran...

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Published in:Life Sciences
Main Author: Lee Z.Y.; Lee W.H.; Lim J.S.; Ali A.A.A.; Loo J.S.E.; Wibowo A.; Mohammat M.F.; Foo J.B.
Format: Review
Language:English
Published: Elsevier Inc. 2024
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197361707&doi=10.1016%2fj.lfs.2024.122868&partnerID=40&md5=8e6642fd91cbfed7637399307f053a17
id 2-s2.0-85197361707
spelling 2-s2.0-85197361707
Lee Z.Y.; Lee W.H.; Lim J.S.; Ali A.A.A.; Loo J.S.E.; Wibowo A.; Mohammat M.F.; Foo J.B.
Golgi apparatus targeted therapy in cancer: Are we there yet?
2024
Life Sciences
352

10.1016/j.lfs.2024.122868
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197361707&doi=10.1016%2fj.lfs.2024.122868&partnerID=40&md5=8e6642fd91cbfed7637399307f053a17
Membrane trafficking within the Golgi apparatus plays a pivotal role in the intracellular transportation of lipids and proteins. Dysregulation of this process can give rise to various pathological manifestations, including cancer. Exploiting Golgi defects, cancer cells capitalise on aberrant membrane trafficking to facilitate signal transduction, proliferation, invasion, immune modulation, angiogenesis, and metastasis. Despite the identification of several molecular signalling pathways associated with Golgi abnormalities, there remains a lack of approved drugs specifically targeting cancer cells through the manipulation of the Golgi apparatus. In the initial section of this comprehensive review, the focus is directed towards delineating the abnormal Golgi genes and proteins implicated in carcinogenesis. Subsequently, a thorough examination is conducted on the impact of these variations on Golgi function, encompassing aspects such as vesicular trafficking, glycosylation, autophagy, oxidative mechanisms, and pH alterations. Lastly, the review provides a current update on promising Golgi apparatus-targeted inhibitors undergoing preclinical and/or clinical trials, offering insights into their potential as therapeutic interventions. Significantly more effort is required to advance these potential inhibitors to benefit patients in clinical settings. © 2024 Elsevier Inc.
Elsevier Inc.
243205
English
Review

author Lee Z.Y.; Lee W.H.; Lim J.S.; Ali A.A.A.; Loo J.S.E.; Wibowo A.; Mohammat M.F.; Foo J.B.
spellingShingle Lee Z.Y.; Lee W.H.; Lim J.S.; Ali A.A.A.; Loo J.S.E.; Wibowo A.; Mohammat M.F.; Foo J.B.
Golgi apparatus targeted therapy in cancer: Are we there yet?
author_facet Lee Z.Y.; Lee W.H.; Lim J.S.; Ali A.A.A.; Loo J.S.E.; Wibowo A.; Mohammat M.F.; Foo J.B.
author_sort Lee Z.Y.; Lee W.H.; Lim J.S.; Ali A.A.A.; Loo J.S.E.; Wibowo A.; Mohammat M.F.; Foo J.B.
title Golgi apparatus targeted therapy in cancer: Are we there yet?
title_short Golgi apparatus targeted therapy in cancer: Are we there yet?
title_full Golgi apparatus targeted therapy in cancer: Are we there yet?
title_fullStr Golgi apparatus targeted therapy in cancer: Are we there yet?
title_full_unstemmed Golgi apparatus targeted therapy in cancer: Are we there yet?
title_sort Golgi apparatus targeted therapy in cancer: Are we there yet?
publishDate 2024
container_title Life Sciences
container_volume 352
container_issue
doi_str_mv 10.1016/j.lfs.2024.122868
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197361707&doi=10.1016%2fj.lfs.2024.122868&partnerID=40&md5=8e6642fd91cbfed7637399307f053a17
description Membrane trafficking within the Golgi apparatus plays a pivotal role in the intracellular transportation of lipids and proteins. Dysregulation of this process can give rise to various pathological manifestations, including cancer. Exploiting Golgi defects, cancer cells capitalise on aberrant membrane trafficking to facilitate signal transduction, proliferation, invasion, immune modulation, angiogenesis, and metastasis. Despite the identification of several molecular signalling pathways associated with Golgi abnormalities, there remains a lack of approved drugs specifically targeting cancer cells through the manipulation of the Golgi apparatus. In the initial section of this comprehensive review, the focus is directed towards delineating the abnormal Golgi genes and proteins implicated in carcinogenesis. Subsequently, a thorough examination is conducted on the impact of these variations on Golgi function, encompassing aspects such as vesicular trafficking, glycosylation, autophagy, oxidative mechanisms, and pH alterations. Lastly, the review provides a current update on promising Golgi apparatus-targeted inhibitors undergoing preclinical and/or clinical trials, offering insights into their potential as therapeutic interventions. Significantly more effort is required to advance these potential inhibitors to benefit patients in clinical settings. © 2024 Elsevier Inc.
publisher Elsevier Inc.
issn 243205
language English
format Review
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record_format scopus
collection Scopus
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