Discovery of novel 1,8-naphthalimide piperazinamide based benzenesulfonamides derivatives as potent carbonic anhydrase IX inhibitors and ferroptosis inducers for the treatment of triple-negative breast cancer

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Discovery of novel 1,8-naphthalimide piperazinamide based benzenesulfonamides derivatives as potent carbonic anhydrase IX inhibitors and ferroptosis inducers for the treatment of triple-negative breast cancer

A novel series of 1,8-naphthalimide piperazinamide based benzenesulfonamides derivatives were designed and synthesized as carbonic anhydrase IX (CA IX) inhibitors and ferroptosis inducers for the treatment of triple-negative breast cancer (TNBC). The representative compound 9o exhibited more potent...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Liang Q.; Zhang S.; Liu J.; Zhou X.; Syamimi Ariffin N.; Wei J.; Shi C.; Ma X.; Zhang Y.; Huang R.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197352734&doi=10.1016%2fj.bioorg.2024.107596&partnerID=40&md5=2599f7da6113c2d09a3bb8ffa1eaf04b

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