Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications
The optimization of respiratory health is important, and one avenue for achieving this is through the application of both Pulmonary Drug Delivery System (PDDS) and Intranasal Delivery (IND). PDDS offers immediate delivery of medication to the respiratory system, providing advantages, such as sustain...
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Bentham Science Publishers
2024
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2-s2.0-85196714137 Alwahsh W.; Sahudin S.; Alkhatib H.; Bostanudin M.F.; Alwahsh M. Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications 2024 Current Drug Targets 25 7 10.2174/0113894501301747240417103321 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196714137&doi=10.2174%2f0113894501301747240417103321&partnerID=40&md5=e15964a95beea5c50a43e9ad15687c3d The optimization of respiratory health is important, and one avenue for achieving this is through the application of both Pulmonary Drug Delivery System (PDDS) and Intranasal Delivery (IND). PDDS offers immediate delivery of medication to the respiratory system, providing advantages, such as sustained regional drug concentration, tunable drug release, extended duration of action, and enhanced patient compliance. IND, renowned for its non-invasive nature and swift onset of action, presents a promising path for advancement. Modern PDDS and IND utilize various polymers, among which chitosan (CS) stands out. CS is a biocompatible and biodegradable polysaccharide with unique physicochemical properties, making it well-suited for medical and pharmaceutical applications. The multiple positively charged amino groups present in CS facilitate its interaction with negatively charged mucous membranes, allowing CS to adsorb easily onto the mucosal surface. In addition, CS-based nanocarriers have been an important topic of research. Polymeric Nanoparticles (NPs), liposomes, dendrimers, microspheres, nanoemulsions, Solid Lipid Nanoparticles (SLNs), carbon nanotubes, and modified effective targeting systems compete as important ways of increasing pulmonary drug delivery with chitosan. This review covers the latest findings on CS-based nanocarriers and their applications. © 2024 Bentham Science Publishers. Bentham Science Publishers 13894501 English Review |
author |
Alwahsh W.; Sahudin S.; Alkhatib H.; Bostanudin M.F.; Alwahsh M. |
spellingShingle |
Alwahsh W.; Sahudin S.; Alkhatib H.; Bostanudin M.F.; Alwahsh M. Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications |
author_facet |
Alwahsh W.; Sahudin S.; Alkhatib H.; Bostanudin M.F.; Alwahsh M. |
author_sort |
Alwahsh W.; Sahudin S.; Alkhatib H.; Bostanudin M.F.; Alwahsh M. |
title |
Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications |
title_short |
Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications |
title_full |
Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications |
title_fullStr |
Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications |
title_full_unstemmed |
Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications |
title_sort |
Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications |
publishDate |
2024 |
container_title |
Current Drug Targets |
container_volume |
25 |
container_issue |
7 |
doi_str_mv |
10.2174/0113894501301747240417103321 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196714137&doi=10.2174%2f0113894501301747240417103321&partnerID=40&md5=e15964a95beea5c50a43e9ad15687c3d |
description |
The optimization of respiratory health is important, and one avenue for achieving this is through the application of both Pulmonary Drug Delivery System (PDDS) and Intranasal Delivery (IND). PDDS offers immediate delivery of medication to the respiratory system, providing advantages, such as sustained regional drug concentration, tunable drug release, extended duration of action, and enhanced patient compliance. IND, renowned for its non-invasive nature and swift onset of action, presents a promising path for advancement. Modern PDDS and IND utilize various polymers, among which chitosan (CS) stands out. CS is a biocompatible and biodegradable polysaccharide with unique physicochemical properties, making it well-suited for medical and pharmaceutical applications. The multiple positively charged amino groups present in CS facilitate its interaction with negatively charged mucous membranes, allowing CS to adsorb easily onto the mucosal surface. In addition, CS-based nanocarriers have been an important topic of research. Polymeric Nanoparticles (NPs), liposomes, dendrimers, microspheres, nanoemulsions, Solid Lipid Nanoparticles (SLNs), carbon nanotubes, and modified effective targeting systems compete as important ways of increasing pulmonary drug delivery with chitosan. This review covers the latest findings on CS-based nanocarriers and their applications. © 2024 Bentham Science Publishers. |
publisher |
Bentham Science Publishers |
issn |
13894501 |
language |
English |
format |
Review |
accesstype |
|
record_format |
scopus |
collection |
Scopus |
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1809678475162812416 |