THE RELATIONSHIP OF BIOCHEMICAL MARKERS AND COAGULATION PROFILES WITH THE SURVIVAL STATUS AMONG COVID-19 PATIENTS

• Published in: Malaysian Journal of Public Health Medicine
• Main Author: Samuri N.F.S.M.; Kasim N.A.M.; Isa M.R.; Monir M.A.; Rosli M.M.; Yusoff N.A.; Atikah S.K.
• Format: Article
• Language: English
• Published: Malaysian Public Health Physicians Association 2024
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85196392317&partnerID=40&md5=7ade4243268ea0df7ec2981197423b83

The Coronavirus Disease of 2019 (COVID-19) is an imminent threat to world health, and effective management of COVID-19 patients is needed. Biochemical markers and coagulation profiles are required for medical intervention and prediction of morbidity and mortality. This study aims to determine the relationship between biochemical markers and coagulation profiles with the survival status among COVID-19 patients. A cross-sectional study using secondary data was conducted among 470 COVID-19 patients admitted to Hospital Sungai Buloh from April 2021 to July 2021. The biomarkers include C-reactive protein (CRP), ferritin, procalcitonin (PCT), lactate dehydrogenase (LDH), D-dimer, high-sensitivity troponin I (hs-Trop I), creatine kinase (CK), sodium, potassium, urea, creatinine, alanine transaminase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, activated partial thromboplastin time (APTT) and prothrombin time (PT) along with survival status were extracted from the hospital electronic medical records. The relationship between biomarkers with the survival status among COVID-19 patients was analysed using simple and multiple logistic regression. The results showed an increased odd of mortality in deceased patients, particularly in PCT with an odds ratio (OR) of 1.028 (95%CI: 1.001, 1.055), LDH with an OR of 1.002 (95%CI: 1.001, 1.003), and urea with an OR of 1.070 (95%CI: 1.034, 1.107) compared to survivors. All three biomarkers give 98.7% sensitivity and 13.0% specificity with the area under the curve (AUC) of 0.762 (95%CI: 0.705, 0.820). In summary, our research underscores a significant correlation between the mortality risk of COVID-19 patients and increased PCT, LDH, and urea. © (2024), (Malaysian Public Health Physicians Association). All rights reserved.