Novel acyl hydrazide derivatives of polyhydroquinoline as potent anti-diabetic and anti-glycating agents: Synthesis, in vitro α-amylase, α-glucosidase inhibition and anti-glycating activity with molecular docking insights

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Novel acyl hydrazide derivatives of polyhydroquinoline as potent anti-diabetic and anti-glycating agents: Synthesis, in vitro α-amylase, α-glucosidase inhibition and anti-glycating activity with molecular docking insights

In this study, eleven novel acyl hydrazides derivative of polyhydroquinoline were synthesized, characterized and screened for their in vitro anti-diabetic and anti-glycating activities. Seven compounds 2a, 2d, 2i, 2 h, 2j, 2f, and 2 g exhibited notable α-amylase inhibitory activity having IC50 value...

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Ur Rahman S.; Alam A.; Parveen Z.; Zainab; Assad M.; Adnan Ali Shah S.; Rafiq H.; Ayaz M.; Latif A.; Naveed Umar M.; Ali M.; Ahmad M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85195572078&doi=10.1016%2fj.bioorg.2024.107501&partnerID=40&md5=280850b8beb0febd54b9afd750c38d1a

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