Mechanistic pathway of herbs in the amelioration of NAFLD: A systematic review

Non‑alcoholic fatty liver disease (NAFLD) is identified by lipid accumulation in the liver and liver injury due to obesity and metabolic syndrome. Herbs have been used in the treatment of various diseases, including liver disease. The present systematic review aimed to identify plants and the doses...

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Published in:World Academy of Sciences Journal
Main Author: Jayanti N.E.; Said R.M.; Jofrry S.M.; Choo C.-Y.
Format: Review
Language:English
Published: Spandidos Publications 2024
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194155739&doi=10.3892%2fwasj.2024.245&partnerID=40&md5=db503bdcd7e4cdf438297779baf48827
id 2-s2.0-85194155739
spelling 2-s2.0-85194155739
Jayanti N.E.; Said R.M.; Jofrry S.M.; Choo C.-Y.
Mechanistic pathway of herbs in the amelioration of NAFLD: A systematic review
2024
World Academy of Sciences Journal
6
4
10.3892/wasj.2024.245
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194155739&doi=10.3892%2fwasj.2024.245&partnerID=40&md5=db503bdcd7e4cdf438297779baf48827
Non‑alcoholic fatty liver disease (NAFLD) is identified by lipid accumulation in the liver and liver injury due to obesity and metabolic syndrome. Herbs have been used in the treatment of various diseases, including liver disease. The present systematic review aimed to identify plants and the doses used in the management and prevention of NAFLD, as well as to assess the safety of these plants and deter‑ mine their mechanisms of action, providing the preclinical evidence‑based usage of herbs. Scientific databases, namely, Scopus, PubMed, Springer, NCBI, Google Scholar, Science Direct, and Web of Science were searched with key words, such as ‘non‑alcoholic fatty liver disease’, ‘non‑alcoholic steatohepatitis’, ‘metabolic‑associated fatty liver disease’, ‘medicinal plants’, ‘hyperlipidemia’ and ‘plant extracts’ from January, 2016 to November, 2023. Manual screening, quality assessment, and data extraction of the search results were performed according to the inclusion and exclusion criteria. Herbs were identified which were able to ameliorate NAFLD symptoms in rodents through lipid metabolism, insulin resistance, inflammation and oxidative stress. These herbs were identified to lead to a reduction in steatosis in the histo‑ pathological assessment. The acute or chronic toxicity studies were not found to indicate any signs of toxicity. The present study provides information on the highest dose evaluated and which was effective against NAFLD, with safety assessment in studies using rats. Since chronic liver diseases progress over a long period of time with minimal or no symptoms, the consumption of herbs may provide alternative treatment strategies for the prevention of NAFLD. Further studies are warranted however, to identify their bioactive compounds for drug development or for the standardization of crude extracts. Drug‑herb interactions also need to be further evaluated when used concurrently with drugs. Copyright © 2024 Jayanti et al.
Spandidos Publications
26322900
English
Review
All Open Access; Gold Open Access
author Jayanti N.E.; Said R.M.; Jofrry S.M.; Choo C.-Y.
spellingShingle Jayanti N.E.; Said R.M.; Jofrry S.M.; Choo C.-Y.
Mechanistic pathway of herbs in the amelioration of NAFLD: A systematic review
author_facet Jayanti N.E.; Said R.M.; Jofrry S.M.; Choo C.-Y.
author_sort Jayanti N.E.; Said R.M.; Jofrry S.M.; Choo C.-Y.
title Mechanistic pathway of herbs in the amelioration of NAFLD: A systematic review
title_short Mechanistic pathway of herbs in the amelioration of NAFLD: A systematic review
title_full Mechanistic pathway of herbs in the amelioration of NAFLD: A systematic review
title_fullStr Mechanistic pathway of herbs in the amelioration of NAFLD: A systematic review
title_full_unstemmed Mechanistic pathway of herbs in the amelioration of NAFLD: A systematic review
title_sort Mechanistic pathway of herbs in the amelioration of NAFLD: A systematic review
publishDate 2024
container_title World Academy of Sciences Journal
container_volume 6
container_issue 4
doi_str_mv 10.3892/wasj.2024.245
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194155739&doi=10.3892%2fwasj.2024.245&partnerID=40&md5=db503bdcd7e4cdf438297779baf48827
description Non‑alcoholic fatty liver disease (NAFLD) is identified by lipid accumulation in the liver and liver injury due to obesity and metabolic syndrome. Herbs have been used in the treatment of various diseases, including liver disease. The present systematic review aimed to identify plants and the doses used in the management and prevention of NAFLD, as well as to assess the safety of these plants and deter‑ mine their mechanisms of action, providing the preclinical evidence‑based usage of herbs. Scientific databases, namely, Scopus, PubMed, Springer, NCBI, Google Scholar, Science Direct, and Web of Science were searched with key words, such as ‘non‑alcoholic fatty liver disease’, ‘non‑alcoholic steatohepatitis’, ‘metabolic‑associated fatty liver disease’, ‘medicinal plants’, ‘hyperlipidemia’ and ‘plant extracts’ from January, 2016 to November, 2023. Manual screening, quality assessment, and data extraction of the search results were performed according to the inclusion and exclusion criteria. Herbs were identified which were able to ameliorate NAFLD symptoms in rodents through lipid metabolism, insulin resistance, inflammation and oxidative stress. These herbs were identified to lead to a reduction in steatosis in the histo‑ pathological assessment. The acute or chronic toxicity studies were not found to indicate any signs of toxicity. The present study provides information on the highest dose evaluated and which was effective against NAFLD, with safety assessment in studies using rats. Since chronic liver diseases progress over a long period of time with minimal or no symptoms, the consumption of herbs may provide alternative treatment strategies for the prevention of NAFLD. Further studies are warranted however, to identify their bioactive compounds for drug development or for the standardization of crude extracts. Drug‑herb interactions also need to be further evaluated when used concurrently with drugs. Copyright © 2024 Jayanti et al.
publisher Spandidos Publications
issn 26322900
language English
format Review
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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