Design of potent tyrosinase inhibiting N-arylated-4-yl-benzamides bearing 2-aminothiazole-triazole bi-heterocycles: mechanistic insight through enzyme inhibition, kinetics and computational studies

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Design of potent tyrosinase inhibiting N-arylated-4-yl-benzamides bearing 2-aminothiazole-triazole bi-heterocycles: mechanistic insight through enzyme inhibition, kinetics and computational studies

By using a convergent methodology, a unique series of N-arylated 4-yl-benzamides containing a bi-heterocyclic thiazole-triazole core was synthesized and the structures of these hybrid molecules, 9a-k, were corroborated through spectral analyses. The in vitro studies of these multi-functional molecul...

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Bibliographic Details
Published in:	RSC Advances
Main Author:	Khan F.M.; Abbasi M.A.; Rehman A.-U.; Siddiqui S.Z.; Sadiq Butt A.R.; Raza H.; Hassan M.; Ali Shah S.A.; Shahid M.; Kim S.J.
Format:	Article
Language:	English
Published:	Royal Society of Chemistry 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85194053288&doi=10.1039%2fd4ra01063a&partnerID=40&md5=b663ecb384fd7754b1d7b73422febbd8

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