Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis

Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis

Purpose: Varicocele has been associated with high seminal oxidative stress (OS), impaired semen quality, and reduced male fertility potential. However, the exact mechanism(s) underlying the development of varicocele-mediated infertility and the cause-effect relationship between varicocele and testic...

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Published in:World Journal of Men's Health
Main Author: Russo G.I.; Saleh R.; Finocchi F.; Juma A.R.; Durairajanayagam D.; Kahraman O.; Sögütdelen E.; Sokolakis I.; Vishwakarma R.B.; Bahar F.; Harraz A.M.; Kavoussi P.; Atmoko W.; Chung E.; Kumar N.; Zohdy W.; Rambhatla A.; Arafa M.; Phuoc N.H.V.; Salvio G.; Calogero A.E.; Toprak T.; Pinggera G.-M.; Cannarella R.; Colpi G.; Hamoda T.A.-A.A.-M.; Shah R.; Agarwal A.
Format: Article
Language:English
Published: Korean Society for Sexual Medicine and Andrology 2024
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193415964&doi=10.5534%2fwjmh.230260&partnerID=40&md5=4f2d16eac36f4e9424b6202fcc488ad6
id 2-s2.0-85193415964
spelling 2-s2.0-85193415964
Russo G.I.; Saleh R.; Finocchi F.; Juma A.R.; Durairajanayagam D.; Kahraman O.; Sögütdelen E.; Sokolakis I.; Vishwakarma R.B.; Bahar F.; Harraz A.M.; Kavoussi P.; Atmoko W.; Chung E.; Kumar N.; Zohdy W.; Rambhatla A.; Arafa M.; Phuoc N.H.V.; Salvio G.; Calogero A.E.; Toprak T.; Pinggera G.-M.; Cannarella R.; Colpi G.; Hamoda T.A.-A.A.-M.; Shah R.; Agarwal A.
Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis
2024
World Journal of Men's Health
42

10.5534/wjmh.230260
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193415964&doi=10.5534%2fwjmh.230260&partnerID=40&md5=4f2d16eac36f4e9424b6202fcc488ad6
Purpose: Varicocele has been associated with high seminal oxidative stress (OS), impaired semen quality, and reduced male fertility potential. However, the exact mechanism(s) underlying the development of varicocele-mediated infertility and the cause-effect relationship between varicocele and testicular dysfunction are not fully understood. The aim of this systematic review and meta-analysis (SRMA) is to investigate the impact of varicocele on testicular OS markers and sperm parameters in experimental animals with varicocele as compared to animals without varicocele. Materials and Methods: A literature search was performed using the Scopus and PubMed databases on studies that investigated testicular OS markers and sperm parameters in animals with varicocele. The primary outcomes included malondialdehyde (MDA) (nmol/mg) levels whereas the secondary outcomes included total sperm count (×106), sperm vitality (%), total sperm motility (%), and sperm DNA fragmentation (SDF) (%). Standardized mean difference (SMD) (95% confidence interval [CI]) was chosen to express the effect size. The quality of the included studies was evaluated using the Cambridge Quality Checklist. Results: Out of 76 identified articles, 6 studies on rats were included in the meta-analysis. The analysis showed a significant increase of MDA (SMD: 15.61 [1.93, 29.29]; p=0.03) in rats with varicocele vs. controls. We also observed a significant decrease in total sperm count (SMD: -17.45 [-28.97, -5.93]; p<0.01), sperm vitality (SMD: -16.41 [-26.30, -6.52]; p<0.01), total sperm motility (SMD: -17.67 [-24.90, -10.44]; p<0.01), and a significant increase of SDF (SMD: 7.41 [1.23, 13.59]; p=0.02), in rats with varicocele vs. controls. The quality of the included studies was ranked as high. Conclusions: This SRMA indicates a significant increase in levels of testicular MDA and SDF and a reduction of sperm quality in experimental animals with varicocele. These findings support the potential role of testicular OS in the development of varicocele-induced testicular damage. Copyright © 2024 Korean Society for Sexual Medicine and Andrology.
Korean Society for Sexual Medicine and Andrology
22874208
English
Article
All Open Access; Gold Open Access
author Russo G.I.; Saleh R.; Finocchi F.; Juma A.R.; Durairajanayagam D.; Kahraman O.; Sögütdelen E.; Sokolakis I.; Vishwakarma R.B.; Bahar F.; Harraz A.M.; Kavoussi P.; Atmoko W.; Chung E.; Kumar N.; Zohdy W.; Rambhatla A.; Arafa M.; Phuoc N.H.V.; Salvio G.; Calogero A.E.; Toprak T.; Pinggera G.-M.; Cannarella R.; Colpi G.; Hamoda T.A.-A.A.-M.; Shah R.; Agarwal A.
spellingShingle Russo G.I.; Saleh R.; Finocchi F.; Juma A.R.; Durairajanayagam D.; Kahraman O.; Sögütdelen E.; Sokolakis I.; Vishwakarma R.B.; Bahar F.; Harraz A.M.; Kavoussi P.; Atmoko W.; Chung E.; Kumar N.; Zohdy W.; Rambhatla A.; Arafa M.; Phuoc N.H.V.; Salvio G.; Calogero A.E.; Toprak T.; Pinggera G.-M.; Cannarella R.; Colpi G.; Hamoda T.A.-A.A.-M.; Shah R.; Agarwal A.
Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis
author_facet Russo G.I.; Saleh R.; Finocchi F.; Juma A.R.; Durairajanayagam D.; Kahraman O.; Sögütdelen E.; Sokolakis I.; Vishwakarma R.B.; Bahar F.; Harraz A.M.; Kavoussi P.; Atmoko W.; Chung E.; Kumar N.; Zohdy W.; Rambhatla A.; Arafa M.; Phuoc N.H.V.; Salvio G.; Calogero A.E.; Toprak T.; Pinggera G.-M.; Cannarella R.; Colpi G.; Hamoda T.A.-A.A.-M.; Shah R.; Agarwal A.
author_sort Russo G.I.; Saleh R.; Finocchi F.; Juma A.R.; Durairajanayagam D.; Kahraman O.; Sögütdelen E.; Sokolakis I.; Vishwakarma R.B.; Bahar F.; Harraz A.M.; Kavoussi P.; Atmoko W.; Chung E.; Kumar N.; Zohdy W.; Rambhatla A.; Arafa M.; Phuoc N.H.V.; Salvio G.; Calogero A.E.; Toprak T.; Pinggera G.-M.; Cannarella R.; Colpi G.; Hamoda T.A.-A.A.-M.; Shah R.; Agarwal A.
title Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis
title_short Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis
title_full Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis
title_fullStr Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis
title_full_unstemmed Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis
title_sort Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis
publishDate 2024
container_title World Journal of Men's Health
container_volume 42
container_issue
doi_str_mv 10.5534/wjmh.230260
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193415964&doi=10.5534%2fwjmh.230260&partnerID=40&md5=4f2d16eac36f4e9424b6202fcc488ad6
description Purpose: Varicocele has been associated with high seminal oxidative stress (OS), impaired semen quality, and reduced male fertility potential. However, the exact mechanism(s) underlying the development of varicocele-mediated infertility and the cause-effect relationship between varicocele and testicular dysfunction are not fully understood. The aim of this systematic review and meta-analysis (SRMA) is to investigate the impact of varicocele on testicular OS markers and sperm parameters in experimental animals with varicocele as compared to animals without varicocele. Materials and Methods: A literature search was performed using the Scopus and PubMed databases on studies that investigated testicular OS markers and sperm parameters in animals with varicocele. The primary outcomes included malondialdehyde (MDA) (nmol/mg) levels whereas the secondary outcomes included total sperm count (×106), sperm vitality (%), total sperm motility (%), and sperm DNA fragmentation (SDF) (%). Standardized mean difference (SMD) (95% confidence interval [CI]) was chosen to express the effect size. The quality of the included studies was evaluated using the Cambridge Quality Checklist. Results: Out of 76 identified articles, 6 studies on rats were included in the meta-analysis. The analysis showed a significant increase of MDA (SMD: 15.61 [1.93, 29.29]; p=0.03) in rats with varicocele vs. controls. We also observed a significant decrease in total sperm count (SMD: -17.45 [-28.97, -5.93]; p<0.01), sperm vitality (SMD: -16.41 [-26.30, -6.52]; p<0.01), total sperm motility (SMD: -17.67 [-24.90, -10.44]; p<0.01), and a significant increase of SDF (SMD: 7.41 [1.23, 13.59]; p=0.02), in rats with varicocele vs. controls. The quality of the included studies was ranked as high. Conclusions: This SRMA indicates a significant increase in levels of testicular MDA and SDF and a reduction of sperm quality in experimental animals with varicocele. These findings support the potential role of testicular OS in the development of varicocele-induced testicular damage. Copyright © 2024 Korean Society for Sexual Medicine and Andrology.
publisher Korean Society for Sexual Medicine and Andrology
issn 22874208
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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