Iron-related Genes and Proteins Involved in Iron Homeostasis in Animal Models of Allergic Asthma: A Systematic Review

The involvement of the immune oxidative stress response in the pathophysiology and pathogenesis of allergic asthma is well documented. However, reports on the role of iron homeostasis in allergic asthma is scarce. Therefore, this study aims to identify iron-related genes and proteins in mouse models...

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Published in:Biological Trace Element Research
Main Author: Wafriy C.I.; Nor-Ashikin M.N.K.; Kamsani Y.S.; Muid S.A.; Sarbandi M.S.
Format: Review
Language:English
Published: Springer 2024
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192719836&doi=10.1007%2fs12011-024-04183-8&partnerID=40&md5=64f95a8184abd5aa284b8fe7cc7b2510
id 2-s2.0-85192719836
spelling 2-s2.0-85192719836
Wafriy C.I.; Nor-Ashikin M.N.K.; Kamsani Y.S.; Muid S.A.; Sarbandi M.S.
Iron-related Genes and Proteins Involved in Iron Homeostasis in Animal Models of Allergic Asthma: A Systematic Review
2024
Biological Trace Element Research


10.1007/s12011-024-04183-8
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192719836&doi=10.1007%2fs12011-024-04183-8&partnerID=40&md5=64f95a8184abd5aa284b8fe7cc7b2510
The involvement of the immune oxidative stress response in the pathophysiology and pathogenesis of allergic asthma is well documented. However, reports on the role of iron homeostasis in allergic asthma is scarce. Therefore, this study aims to identify iron-related genes and proteins in mouse models of allergic asthma. Related articles were identified from SCOPUS and Web of Science databases. The article search was limited to publications in English, within a 10-year period (2014 – 2023, up to 16 August 2023) and original/research papers. All identified articles were screened for eligibility using the inclusion and exclusion criteria. All eligible articles were quality appraised prior to data extraction. Five studies were selected for data extraction. Based on the extracted data, three themes and seven subthemes related to iron homeostasis were identified. The type of samples and analytical methods used were also identified. In conclusion, our study elucidates that iron-related proteins are regulated in animal models of allergic asthma. However, the currently available data do not allow us to conclude whether the disease model resulted in iron accumulation or depletion. Therefore, further studies with other related markers should be conducted. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Springer
1634984
English
Review

author Wafriy C.I.; Nor-Ashikin M.N.K.; Kamsani Y.S.; Muid S.A.; Sarbandi M.S.
spellingShingle Wafriy C.I.; Nor-Ashikin M.N.K.; Kamsani Y.S.; Muid S.A.; Sarbandi M.S.
Iron-related Genes and Proteins Involved in Iron Homeostasis in Animal Models of Allergic Asthma: A Systematic Review
author_facet Wafriy C.I.; Nor-Ashikin M.N.K.; Kamsani Y.S.; Muid S.A.; Sarbandi M.S.
author_sort Wafriy C.I.; Nor-Ashikin M.N.K.; Kamsani Y.S.; Muid S.A.; Sarbandi M.S.
title Iron-related Genes and Proteins Involved in Iron Homeostasis in Animal Models of Allergic Asthma: A Systematic Review
title_short Iron-related Genes and Proteins Involved in Iron Homeostasis in Animal Models of Allergic Asthma: A Systematic Review
title_full Iron-related Genes and Proteins Involved in Iron Homeostasis in Animal Models of Allergic Asthma: A Systematic Review
title_fullStr Iron-related Genes and Proteins Involved in Iron Homeostasis in Animal Models of Allergic Asthma: A Systematic Review
title_full_unstemmed Iron-related Genes and Proteins Involved in Iron Homeostasis in Animal Models of Allergic Asthma: A Systematic Review
title_sort Iron-related Genes and Proteins Involved in Iron Homeostasis in Animal Models of Allergic Asthma: A Systematic Review
publishDate 2024
container_title Biological Trace Element Research
container_volume
container_issue
doi_str_mv 10.1007/s12011-024-04183-8
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192719836&doi=10.1007%2fs12011-024-04183-8&partnerID=40&md5=64f95a8184abd5aa284b8fe7cc7b2510
description The involvement of the immune oxidative stress response in the pathophysiology and pathogenesis of allergic asthma is well documented. However, reports on the role of iron homeostasis in allergic asthma is scarce. Therefore, this study aims to identify iron-related genes and proteins in mouse models of allergic asthma. Related articles were identified from SCOPUS and Web of Science databases. The article search was limited to publications in English, within a 10-year period (2014 – 2023, up to 16 August 2023) and original/research papers. All identified articles were screened for eligibility using the inclusion and exclusion criteria. All eligible articles were quality appraised prior to data extraction. Five studies were selected for data extraction. Based on the extracted data, three themes and seven subthemes related to iron homeostasis were identified. The type of samples and analytical methods used were also identified. In conclusion, our study elucidates that iron-related proteins are regulated in animal models of allergic asthma. However, the currently available data do not allow us to conclude whether the disease model resulted in iron accumulation or depletion. Therefore, further studies with other related markers should be conducted. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
publisher Springer
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language English
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