Tetraspanin CD9 peptides for membrane disruptive on P. aeruginosa
The rapid development of multidrug-resistant strains and nosocomial P. aeruginosa infections pose a growing threat in the clinical setting. Tetraspanin CD9 peptides has demonstrated the antimicrobial activity against various gram-positive and-negative bacteria. Recently, CD9 peptides have shown anti...
Published in: | Asia-Pacific Journal of Molecular Biology and Biotechnology |
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University of Malaya
2024
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2-s2.0-85191956689 Murad K.; Ab-Rahim S.; Al-Talib H. Tetraspanin CD9 peptides for membrane disruptive on P. aeruginosa 2024 Asia-Pacific Journal of Molecular Biology and Biotechnology 32 2 10.35118/apjmbb.2024.032.2.03 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191956689&doi=10.35118%2fapjmbb.2024.032.2.03&partnerID=40&md5=d31857abc680cb147bcb5384d6db575e The rapid development of multidrug-resistant strains and nosocomial P. aeruginosa infections pose a growing threat in the clinical setting. Tetraspanin CD9 peptides has demonstrated the antimicrobial activity against various gram-positive and-negative bacteria. Recently, CD9 peptides have shown anti-adhesion properties against P. aeruginosa isolates. In this study, we investigated the effect of CD9 peptides on the membrane of P. aeruginosa by transmission electron microscopy (TEM). The result shows the CD9 peptides cause disruption of the membrane of P. aeruginosa. In addition to the established antibacterial properties, this work reveals that tetraspanin CD9 peptides, a membrane-disrupting drug, could possibly be used as an additional treatment approach against P. aeruginosa. Future research should incorporate confocal microscopy to locate the bacterial matrix components and distinguish between living and dead P. aeruginosa upon the treatment with CD9 peptides. © 2024, University of Malaya. All rights reserved. University of Malaya 1287451 English Article All Open Access; Gold Open Access |
author |
Murad K.; Ab-Rahim S.; Al-Talib H. |
spellingShingle |
Murad K.; Ab-Rahim S.; Al-Talib H. Tetraspanin CD9 peptides for membrane disruptive on P. aeruginosa |
author_facet |
Murad K.; Ab-Rahim S.; Al-Talib H. |
author_sort |
Murad K.; Ab-Rahim S.; Al-Talib H. |
title |
Tetraspanin CD9 peptides for membrane disruptive on P. aeruginosa |
title_short |
Tetraspanin CD9 peptides for membrane disruptive on P. aeruginosa |
title_full |
Tetraspanin CD9 peptides for membrane disruptive on P. aeruginosa |
title_fullStr |
Tetraspanin CD9 peptides for membrane disruptive on P. aeruginosa |
title_full_unstemmed |
Tetraspanin CD9 peptides for membrane disruptive on P. aeruginosa |
title_sort |
Tetraspanin CD9 peptides for membrane disruptive on P. aeruginosa |
publishDate |
2024 |
container_title |
Asia-Pacific Journal of Molecular Biology and Biotechnology |
container_volume |
32 |
container_issue |
2 |
doi_str_mv |
10.35118/apjmbb.2024.032.2.03 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191956689&doi=10.35118%2fapjmbb.2024.032.2.03&partnerID=40&md5=d31857abc680cb147bcb5384d6db575e |
description |
The rapid development of multidrug-resistant strains and nosocomial P. aeruginosa infections pose a growing threat in the clinical setting. Tetraspanin CD9 peptides has demonstrated the antimicrobial activity against various gram-positive and-negative bacteria. Recently, CD9 peptides have shown anti-adhesion properties against P. aeruginosa isolates. In this study, we investigated the effect of CD9 peptides on the membrane of P. aeruginosa by transmission electron microscopy (TEM). The result shows the CD9 peptides cause disruption of the membrane of P. aeruginosa. In addition to the established antibacterial properties, this work reveals that tetraspanin CD9 peptides, a membrane-disrupting drug, could possibly be used as an additional treatment approach against P. aeruginosa. Future research should incorporate confocal microscopy to locate the bacterial matrix components and distinguish between living and dead P. aeruginosa upon the treatment with CD9 peptides. © 2024, University of Malaya. All rights reserved. |
publisher |
University of Malaya |
issn |
1287451 |
language |
English |
format |
Article |
accesstype |
All Open Access; Gold Open Access |
record_format |
scopus |
collection |
Scopus |
_version_ |
1809677885094494208 |