Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb
Phytochemical investigation of the leaves of Knema intermedia has led to the isolation of a new furofuran lignan, intermedianin 1 together with five known lignans, α-cubebin 2, β-cubebin 3, bicubebin A 4, bicubebin B 5, and bicubebin C 6. The characterisation and structural elucidation of the isolat...
| Published in: | Natural Product Research |
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| Language: | English |
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Taylor and Francis Ltd.
2024
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191067939&doi=10.1080%2f14786419.2024.2345758&partnerID=40&md5=bae046bfc5dcd3c96668b1d9af48ff1e |
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2-s2.0-85191067939 Salihu A.S.; Salleh W.M.N.H.W.; Barker D.; Arzmi M.H.; Ab Ghani N.; Rasol N.E. Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb 2024 Natural Product Research 10.1080/14786419.2024.2345758 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191067939&doi=10.1080%2f14786419.2024.2345758&partnerID=40&md5=bae046bfc5dcd3c96668b1d9af48ff1e Phytochemical investigation of the leaves of Knema intermedia has led to the isolation of a new furofuran lignan, intermedianin 1 together with five known lignans, α-cubebin 2, β-cubebin 3, bicubebin A 4, bicubebin B 5, and bicubebin C 6. The characterisation and structural elucidation of the isolated compounds were established by extensive spectroscopic data analysis and comparison with literature data. The antifungal activity was tested using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. Compound 1 exhibited activity against C. albicans, C. lusitanae, and C. auris, (each with MIC/MFC value 250 µg/mL) and increased the biofilm of C. auris (64.07 ± 3.83%) and Candida lusitanae (62.90 ± 3.41%) when treated with 500 µg/mL. © 2024 Informa UK Limited, trading as Taylor & Francis Group. Taylor and Francis Ltd. 14786419 English Article |
| author |
Salihu A.S.; Salleh W.M.N.H.W.; Barker D.; Arzmi M.H.; Ab Ghani N.; Rasol N.E. |
| spellingShingle |
Salihu A.S.; Salleh W.M.N.H.W.; Barker D.; Arzmi M.H.; Ab Ghani N.; Rasol N.E. Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb |
| author_facet |
Salihu A.S.; Salleh W.M.N.H.W.; Barker D.; Arzmi M.H.; Ab Ghani N.; Rasol N.E. |
| author_sort |
Salihu A.S.; Salleh W.M.N.H.W.; Barker D.; Arzmi M.H.; Ab Ghani N.; Rasol N.E. |
| title |
Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb |
| title_short |
Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb |
| title_full |
Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb |
| title_fullStr |
Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb |
| title_full_unstemmed |
Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb |
| title_sort |
Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb |
| publishDate |
2024 |
| container_title |
Natural Product Research |
| container_volume |
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| container_issue |
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| doi_str_mv |
10.1080/14786419.2024.2345758 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191067939&doi=10.1080%2f14786419.2024.2345758&partnerID=40&md5=bae046bfc5dcd3c96668b1d9af48ff1e |
| description |
Phytochemical investigation of the leaves of Knema intermedia has led to the isolation of a new furofuran lignan, intermedianin 1 together with five known lignans, α-cubebin 2, β-cubebin 3, bicubebin A 4, bicubebin B 5, and bicubebin C 6. The characterisation and structural elucidation of the isolated compounds were established by extensive spectroscopic data analysis and comparison with literature data. The antifungal activity was tested using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. Compound 1 exhibited activity against C. albicans, C. lusitanae, and C. auris, (each with MIC/MFC value 250 µg/mL) and increased the biofilm of C. auris (64.07 ± 3.83%) and Candida lusitanae (62.90 ± 3.41%) when treated with 500 µg/mL. © 2024 Informa UK Limited, trading as Taylor & Francis Group. |
| publisher |
Taylor and Francis Ltd. |
| issn |
14786419 |
| language |
English |
| format |
Article |
| accesstype |
|
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1809677885302112256 |