CURCUMA AERUGINOSA ROXB. EXTRACT INHIBITS THE PRODUCTION OF PROINFLAMMATORY CYTOKINES ON RAW 264.7 MACROPHAGES

• Published in: International Journal of Applied Pharmaceutics
• Main Author: Dewi I.P.; Dachriyanus; Aldi Y.; Ismail N.H.; Hefni D.; Susanti M.; Syafri S.; Wahyuni F.S.
• Format: Article
• Language: English
• Published: Innovare Academics Sciences Pvt. Ltd 2024
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85190956205&doi=10.22159%2fijap.2024.v16s1.08&partnerID=40&md5=a9ae83ac0223e287b665a840098fea81

Objective: The study explores the potential of Curcuma aeruginosa Roxb. extract for anti-inflammatory properties. Methods: Curcuma aeruginosa Roxb. simplicia was macerated with distilled ethanol. In vitro testing was done on Raw 264.7 macrophages to fulfill this aim by observing Tumor Necrosis Factor (TNF)-α, Interleukin (IL)-6 production and phagocytosis activity. The production of IL-6 and TNF-α were determined using the ELISA method while phagocytosis activity using the neutral red uptake method. Results: The results showed that Curcuma aeruginosa Roxb. extract inhibited production of TNF-α and IL-6 and phagocytic activity and on Raw 264.7 macrophages. Conclusion: The results demonstrated that Curcuma aeruginosa Roxb. extract could be developed as an anti-inflammatory, which can be improved as a novel pharmaceutical approach for treating inflammation-related illness. © 2024 The Authors. Published by Innovare Academic Sciences Pvt Ltd.