| Summary: | Potential antibacterial such as Titanium dioxide (TiO2) is being extensively studied throughout the research world. The modified hydrothermal nanotitania extraction was shown to inhibit Staphylococcus aureus in our lab test. The reaction of our substance to the rat skin and its behaviour is unknown. We observe the effect of modified hydrothermal nanotitania extraction to the Spraque Dawley rat skin and its reaction to it. Sprague Dawley (Rattus norvegicus) rats were used as the experimental animals. The skin around their dorsum of the tested animal were shaved and pasted with 0.1mg and 0.5mg nanotitania extraction. The colour of the pasted area and the behaviour of the animals were observed. 0.1 mg nanotitania extraction application on dorsum of the rat showed no skin colour changes at day 1, day 3, day 5 and day 7 post application. There no changes in their behaviour up to day 7 with no skin rashes or skin scratches seen or fur changes. 0.5mg of nanotitania extraction showed redness and less fur growth at day 7. Our 0.1mg modified nanotitania extraction is observed as no effect to the rat skin. © 2024 Author(s).
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