Synthesis, Characterization, Docking Studies and in vitro Response of New Camptothecin Derivatives towards Oral Squamous Cell Carcinoma

QR Code

Synthesis, Characterization, Docking Studies and in vitro Response of New Camptothecin Derivatives towards Oral Squamous Cell Carcinoma

Evidence suggests heterocyclic rings as the essential component of various available chemotherapeutics. Present study was aimed to carry out the molecular docking, synthesis, characterization and response of new camptothecin derivatives (NCDs) towards OSCC cell lines. To achieve the aim of the study...

Full description

Bibliographic Details
Published in:	Asian Journal of Chemistry
Main Author:	Ugrappa S.; Jagadeesan D.; Lalitha P.; Ravichandran M.; Solyappan M.; Khor G.H.; Wu Y.S.; Balakrishnan V.; Thangeswaran D.; Fuloria S.
Format:	Article
Language:	English
Published:	Asian Publication Corporation 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85187358264&doi=10.14233%2fajchem.2024.31038&partnerID=40&md5=80b172ce170fa1381355577f651cdbef

Similar Items

Synthesis, Characterization and in vitro Anticancer Activity of New Quinoline Analogues against Oral Squamous Cell Carcinoma
by: Ugrappa S.; Fuloria N.K.; Lalitha P.; Ravichandran M.; Noor S.N.F.M.; Solyappan M.; Khor G.H.; Sa’ad M.A.; Jain A.; Wu Y.S.; Balakrishnan V.; Thangeswaran D.; Jagadeesan D.; Fuloria S.
Published: (2023)

Comprehensive insights into oral squamous cell carcinoma: Diagnosis, pathogenesis, and therapeutic advances
by: Jagadeesan D.; Sathasivam K.V.; Fuloria N.K.; Balakrishnan V.; Khor G.H.; Ravichandran M.; Solyappan M.; Fuloria S.; Gupta G.; Ahlawat A.; Yadav G.; Kaur P.; Husseen B.
Published: (2024)

Comprehensive insights into oral squamous cell carcinoma: Diagnosis, pathogenesis, and therapeutic advances
by: Jagadeesan, et al.
Published: (2024)

Screening of differential promoter hypermethylated genes in primary oral squamous cell carcinoma
by: Khor G.H.; Froemming G.R.A.; Zain R.B.; Abraham M.T.; Thong K.L.
Published: (2014)

DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma
by: Khor G.H.; Froemming G.R.A.; Zain R.B.; Thomas Abraham M.; Omar E.; Tan S.K.; Tan A.C.; Vincent-Chong V.K.; Thong K.L.
Published: (2013)

Microsatellite instability and loss of heterozygosity in oral squamous cell carcinoma in Malaysian population
by: Ashazila M.J.J.; Kannan T.P.; Venkatesh R.N.; Hoh B.P.
Published: (2011)

Molecular mechanism of allicin-induced apoptosis in human oral squamous cell carcinoma (OSCC)
by: Hazwani F.; Amin I.M.; Rahim M.A.A.
Published: (2022)

Salvage Mandibulectomy in an Octogenarian with Recurrent Oral Cavity Squamous Cell Carcinoma: A Case Report
by: Azman M.; Yunus M.R.M.; Mohamad M.S.F.
Published: (2023)

Goniothalamus umbrosus Induces Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell Line
by: Aziz N.C.; Alahmad B.E.M.; Kashmoola M.A.; Lestari W.; Mokhtar K.I.; Rosdy N.M.M.N.M.
Published: (2024)

In vitro cytotoxic evaluation and apoptotic effects of dillapiole on human nasal squamous cell carcinoma
by: Ruslan N.B.; Amin I.M.; Hasani N.A.H.; Ahmad V.N.; Aris F.; Heah K.G.
Published: (2021)

Cytotoxic Effect of Bajong LN Rice Methanol Extract on Human Squamous Cell Carcinoma, ORL-48
by: Ahmad, et al.
Published: (2024)

Human papilloma virus 18 detection in oral squamous cell carcinoma and potentially malignant lesions using saliva samples
by: Goot-Heah K.; Kwai-Lin T.; Froemming G.R.A.; Abraham M.T.; Rosdy N.M.M.N.M.; Zain R.B.
Published: (2012)

Findings from a Malaysian multicentre study on oropharyngeal squamous cell carcinoma
by: Sathasivam H.P.; Davan S.P.; Chua S.M.; Rohaizat R.F.; Japar R.; Zakaria Z.; Ahmad A.R.; Hashim H.; Marimuthu S.G.; Liew Y.T.; Yong D.J.; Vairavan P.; Mohan Singh A.S.; Goh B.H.B.; Yusof Z.; Abu Dahari K.A.S.; Haron A.; Mansor M.; Ibrahim M.Z.; Muhammad Abdul Kadar S.Q.; Hamal M.H.; Wan Mohamad W.E.
Published: (2023)

Utilizing Trans-Oral Robotic Surgery (TORS) in head and neck malignancy – is it practical in oropharyngeal squamous cell carcinoma (OPSCC)? A case report
by: Fakhruzzaman M.S.; Khalid A.K.; Halim H.A.; Yunus M.R.M.
Published: (2023)

Squamous cell carcinoma of the skin and voriconazole therapy in lung transplant recipients: A case series
by: Neoh C.F.; Snell G.I.; Levvey B.; Morrissey C.O.; Slavin M.A.; Stewart K.; Kong D.C.M.
Published: (2017)

Cytotoxic Effect of Bajong LN Rice Methanol Extract on Human Squamous Cell Carcinoma, ORL-48
by: Ahmad V.N.; Mohamed N.A.H.; Amom Z.; Heah K.G.; Zain N.M.; Mohd Amin I.
Published: (2024)

The impact of vitamin D deficiency on caries, periodontitis, and oral cancer: A systematic review
by: Hussein A.S.; Rosli R.A.; Ramle R.S.; Khor G.H.
Published: (2024)

Investigation of antiproliferative mechanisms of Alstonia angustiloba-silver nanoparticles in skin squamous cell carcinoma (A431 cell line)
by: Rahim N.A.; Mail M.H.; Muhamad M.; Sapuan S.; SMN Mydin R.B.; Seeni A.
Published: (2022)

A Case Report of a Rare ER+, PR-Pure Metaplastic Breast Squamous Cell Carcinoma with HER2 Overexpression
by: Adam S.A.; Kamaruddin K.N.; Shukor N.A.; Suhaimi S.N.A.; Ismail F.; Yasin M.M.
Published: (2023)

Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery
by: Ramli S.; Wu Y.S.; Batumalaie K.; Guad R.M.; Choy K.W.; Kumar A.; Gopinath S.C.B.; Rahman Sarker M.M.; Subramaniyan V.; Sekar M.; Fuloria N.K.; Fuloria S.; Chinni S.V.; Ramachawolran G.
Published: (2023)

Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms; [Mentafsir Synsepalum dulcificum sebagai Agen Fitoterapi yang semakin Meningkat: Latar Belakang, Sifat Fitokimia dan Farmakologi dengan Mekanisme Molekul Berkaitan]
by: Ee J.W.; Velaga A.; Guad R.M.; Subramaniyan V.; Fuloria N.K.; Fuloria S.; Choy K.W.; Wu Y.S.
Published: (2022)

Spindle Cell Metaplastic Breast Carcinoma
by: Sanmugasiva V.; Hamid M.T.R.; Fadzli F.; Mumin N.A.; Rahmat K.
Published: (2022)

Nasopharyngeal carcinoma in adolescent patients: A case series
by: Sathasivam H.P.; Chew S.Y.L.; Kim W.-R.; Saw C.-L.; Tan L.P.; Tengku Din T.A.D.A.-A.; Adam N.-A.; Hasbullah H.H.; Wan Sohaimi W.F.; Tan T.-Y.; Lum C.-L.; Pua K.-C.; Khoo A.S.-B.
Published: (2022)

Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review; [Pandangan tentang Aktiviti Antikanser, Fitokimia Berkaitan dan Mekanisme Molekul Berpotensi Quisqualis indica: Suatu Kajian Mini]
by: Wu Y.S.; Lee M.F.; Guad R.M.; Ozeer F.Z.; Velaga A.; Subramaniyan V.; Fuloria N.K.; Fuloria S.; Choy K.W.; Lee S.M.; Gopinath S.C.B.; Verma A.; Lau T.P.
Published: (2023)

Amoebic colitis mimicking a colonic carcinoma
by: Abdul Rani R.; Limun M.F.; Naidu J.; Ngiu C.S.; Raja Ali R.A.
Published: (2016)

Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors
by: Tune B.X.J.; Sim M.S.; Poh C.L.; Guad R.M.; Woon C.K.; Hazarika I.; Das A.; Gopinath S.C.B.; Rajan M.; Sekar M.; Subramaniyan V.; Fuloria N.K.; Fuloria S.; Batumalaie K.; Wu Y.S.
Published: (2022)

Synthesis, in vitro urease inhibitory potential and molecular docking study of Benzimidazole analogues
by: Zaman K.; Rahim F.; Taha M.; Ullah H.; Wadood A.; Nawaz M.; Khan F.; Wahab Z.; Shah S.A.A.; Rehman A.U.; Kawde A.-N.; Gollapalli M.
Published: (2019)

Synthesis, in vitro and Docking Studies of New Flavone Ethers as α-Glucosidase Inhibitors
by: Imran S.; Taha M.; Ismail N.H.; Kashif S.M.; Rahim F.; Jamil W.; Wahab H.; Khan K.M.
Published: (2016)

Synthesis, molecular docking study and in vitro thymidine phosphorylase inhibitory potential of oxadiazole derivatives
by: Ullah H.; Rahim F.; Taha M.; Uddin I.; Wadood A.; Shah S.A.A.; Farooq R.K.; Nawaz M.; Wahab Z.; Khan K.M.
Published: (2018)

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs
by: Javid M.T.; Rahim F.; Taha M.; Rehman H.U.; Nawaz M.; wadood A.; Imran S.; Uddin I.; Mosaddik A.; Khan K.M.
Published: (2018)

Synthesis, in vitro α-glucosidase activity and in silico molecular docking study of isatin analogues
by: Ullah H.; Rahim F.; Ullah E.; Hayat S.; Zada H.; Khan F.; Wadood A.; Nawaz F.; Rehman Z.U.; Shah S.A.A.
Published: (2023)

Antibacterial, Anticandidal, and Antibiofilm Potential of Fenchone: In Vitro, Molecular Docking and In Silico/ADMET Study
by: Ahmad W.; Ansari M.A.; Yusuf M.; Amir M.; Wahab S.; Alam P.; Alomary M.N.; Alhuwayri A.A.; Khan M.; Ali A.; Warsi M.H.; Ashraf K.; Ali M.
Published: (2022)

Synthesis, In Vitro α-Amylase Activity, and Molecular Docking Study of New Benzimidazole Derivatives
by: Ullah H.; Ullah H.; Taha M.; Khan F.; Rahim F.; Uddin I.; Sarfraz M.; Shah S.A.A.; Aziz A.; Mubeen S.
Published: (2021)

Molecular docking studies and in-vitro cholinesterase inhibitory activities of chemical constituents of Calophyllum gracilentum
by: Seruji N.M.U.; Jong V.Y.M.; Karunakaran T.; Zamakshshari N.H.; Mah S.H.; Gunter N.V.; Lizazman M.A.; Masayoshi A.
Published: (2024)

Exome Sequencing Identifies Potentially Druggable Mutations in Nasopharyngeal Carcinoma
by: Chow Y.P.; Tan L.P.; Chai S.J.; Abdul Aziz N.; Choo S.W.; Lim P.V.H.; Pathmanathan R.; Kornain N.K.M.; Lum C.L.; Pua K.C.; Yap Y.Y.; Tan T.Y.; Teo S.H.; Khoo A.S.-B.; Patel V.
Published: (2017)

Synthesis of 2-acylated and sulfonated 4-hydroxycoumarins: In vitro urease inhibition and molecular docking studies
by: Rashid U.; Rahim F.; Taha M.; Arshad M.; Ullah H.; Mahmood T.; Ali M.
Published: (2016)

Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase
by: Rahim F.; Ullah H.; Javid M.T.; Wadood A.; Taha M.; Ashraf M.; Shaukat A.; Junaid M.; Hussain S.; Rehman W.; Mehmood R.; Sajid M.; Khan M.N.; Khan K.M.
Published: (2015)

Benzoxazole based thiazole hybrid analogs: Synthesis, in vitro cholinesterase inhibition, and molecular docking studies
by: Hussain R.; Rahim F.; Rehman W.; Adnan Ali Shah S.; Khan S.; Khan I.; Rasheed L.; Imran S.; Wadood A.; Abdellatif M.H.
Published: (2023)

Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
by: Taha M.; Rahim F.; Ullah H.; Wadood A.; Farooq R.K.; Shah S.A.A.; Nawaz M.; Zakaria Z.A.
Published: (2020)

Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives
by: Khan K.M.; Qurban S.; Salar U.; Taha M.; Hussain S.; Perveen S.; Hameed A.; Ismail N.H.; Riaz M.; Wadood A.
Published: (2016)