| Summary: | Microfluidic systems, which are small-scale platforms for controlling fluid flow, have a vast potential to transform numerous industries. This review focuses on the critical role of microfluidic setup configurations in enhancing mixing and reaction efficiencies across diverse industries. We began by examining microchannel designs, including inlet geometries and design shapes. These designs enhance heat distribution and fluid control, ultimately improving mass transfer and mixing efficiency. Our analysis showcases various applications of microfluidic devices in pharmaceuticals, biology, textiles, electronics, and food production. These applications have the potential to revolutionize nanoparticle synthesis, wastewater treatment, and drug detection, particularly in wastewater. Microfluidic devices offer rapid and cost-effective solutions for contaminant and drug monitoring. Customizing fluid pathways and sensors enhances detection precision and speed, enabling real-time pollution monitoring. Moreover, this review highlights the advantages of microfluidics in wastewater treatment compared with conventional methods. It also discusses challenges such as scalability, feasibility, manufacturing costs, raw materials, and energy consumption. This literature review provides a novel contribution to comprehensive, multidisciplinary, and critical analyses of microfluidic setup configurations and their impacts across industries. It not only identifies the potential benefits but also acknowledges and addresses the limitations and challenges of microfluidic systems. © 2024
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