Diabetic Cardiac Autonomic Neuropathy: A Review of NLRP3 Inflammasome Complicity
Debilitating and often misdiagnosed cardiac autonomic neuropathy affects people with diabetes. Damage to the biggest sympathetic trunk ganglion of autonomic nerve fibers that innervate the heart and blood vessels, the superior cervical ganglion (SCG), is the cause of aberrant heart rate and vascular...
Published in: | Malaysian Journal of Medicine and Health Sciences |
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Universiti Putra Malaysia Press
2024
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2-s2.0-85185301755 Subramaniam S.D.; Mhd Zain N.A.L.; Woon C.K.; Omar N.S.; Abas R. Diabetic Cardiac Autonomic Neuropathy: A Review of NLRP3 Inflammasome Complicity 2024 Malaysian Journal of Medicine and Health Sciences 20 1 10.47836/mjmhs.20.1.44 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185301755&doi=10.47836%2fmjmhs.20.1.44&partnerID=40&md5=0e28a76407ec5644880f1851adf45552 Debilitating and often misdiagnosed cardiac autonomic neuropathy affects people with diabetes. Damage to the biggest sympathetic trunk ganglion of autonomic nerve fibers that innervate the heart and blood vessels, the superior cervical ganglion (SCG), is the cause of aberrant heart rate and vascular dynamics in people with diabetic cardiac autonomic neuropathy (DCAN). Mediating host immunological responses to microbial infection and cellular damage, inflammasomes are a class of cytosolic protein complexes that include NLRP3. This review compiled the findings of experimental investigations on DCAN and discussed their connection to the NLRP3 inflammasome’s involvement. SCG P2X7 receptor expression can be boosted by inflammation brought on by hyperglycemia, leading to nerve injury. Unfortunately, there is a lack of research on DCAN-related inflammation in animal models, especially in inflammasome. Currently, only IncRNAUC.360+ shRNA and Schisandrin B, prove to alleviate the pathogenesis. Therefore, more research into the causes and potential remedies for DCAN is necessary. © 2024 Universiti Putra Malaysia Press. All rights reserved. Universiti Putra Malaysia Press 16758544 English Review All Open Access; Bronze Open Access |
author |
Subramaniam S.D.; Mhd Zain N.A.L.; Woon C.K.; Omar N.S.; Abas R. |
spellingShingle |
Subramaniam S.D.; Mhd Zain N.A.L.; Woon C.K.; Omar N.S.; Abas R. Diabetic Cardiac Autonomic Neuropathy: A Review of NLRP3 Inflammasome Complicity |
author_facet |
Subramaniam S.D.; Mhd Zain N.A.L.; Woon C.K.; Omar N.S.; Abas R. |
author_sort |
Subramaniam S.D.; Mhd Zain N.A.L.; Woon C.K.; Omar N.S.; Abas R. |
title |
Diabetic Cardiac Autonomic Neuropathy: A Review of NLRP3 Inflammasome Complicity |
title_short |
Diabetic Cardiac Autonomic Neuropathy: A Review of NLRP3 Inflammasome Complicity |
title_full |
Diabetic Cardiac Autonomic Neuropathy: A Review of NLRP3 Inflammasome Complicity |
title_fullStr |
Diabetic Cardiac Autonomic Neuropathy: A Review of NLRP3 Inflammasome Complicity |
title_full_unstemmed |
Diabetic Cardiac Autonomic Neuropathy: A Review of NLRP3 Inflammasome Complicity |
title_sort |
Diabetic Cardiac Autonomic Neuropathy: A Review of NLRP3 Inflammasome Complicity |
publishDate |
2024 |
container_title |
Malaysian Journal of Medicine and Health Sciences |
container_volume |
20 |
container_issue |
1 |
doi_str_mv |
10.47836/mjmhs.20.1.44 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185301755&doi=10.47836%2fmjmhs.20.1.44&partnerID=40&md5=0e28a76407ec5644880f1851adf45552 |
description |
Debilitating and often misdiagnosed cardiac autonomic neuropathy affects people with diabetes. Damage to the biggest sympathetic trunk ganglion of autonomic nerve fibers that innervate the heart and blood vessels, the superior cervical ganglion (SCG), is the cause of aberrant heart rate and vascular dynamics in people with diabetic cardiac autonomic neuropathy (DCAN). Mediating host immunological responses to microbial infection and cellular damage, inflammasomes are a class of cytosolic protein complexes that include NLRP3. This review compiled the findings of experimental investigations on DCAN and discussed their connection to the NLRP3 inflammasome’s involvement. SCG P2X7 receptor expression can be boosted by inflammation brought on by hyperglycemia, leading to nerve injury. Unfortunately, there is a lack of research on DCAN-related inflammation in animal models, especially in inflammasome. Currently, only IncRNAUC.360+ shRNA and Schisandrin B, prove to alleviate the pathogenesis. Therefore, more research into the causes and potential remedies for DCAN is necessary. © 2024 Universiti Putra Malaysia Press. All rights reserved. |
publisher |
Universiti Putra Malaysia Press |
issn |
16758544 |
language |
English |
format |
Review |
accesstype |
All Open Access; Bronze Open Access |
record_format |
scopus |
collection |
Scopus |
_version_ |
1809678014906105856 |