Chemical Composition and Cytotoxicity of the Essential Oil of Rothmannia schoemannii Tirveng

• Published in: Rivista Italiana delle Sostanze Grasse
• Main Author: Salleh W.M.N.H.W.; Salihu A.S.; Ghani N.A.
• Format: Article
• Language: English
• Published: INNOVHUB - Stazioni Sperimentali per l'Industria S.r.l - Area Oli e Grassi 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184194950&partnerID=40&md5=1f85f5d4ab8935f1c9d00d897faf7e2b

The chemical composition of the essential oil of Rothmannia schoemannii Tirveng. (Rubiaceae) was investigated for the first time. The essential oil was obtained by hydrodistillation and fully characterised by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). In total, 28 components were identified in the essential oil, which made up 99.6% of the total oil. The essential oil is composed mainly of β-eudesmol (30.8%), α-cadinol (18.2%), caryophyllene oxide (6.5%), δ-cadinene (5.5%), and γ-eudesmol (5.4%). The essential oil exhibited cytotoxic activity against J5 (human hepatocellular carcinoma) and A549 (human lung adenocarcinoma) cells with IC50 values of 112.5 and 98.5 ug/mL, respectively. © 2023, INNOVHUB - Stazioni Sperimentali per l'Industria S.r.l - Area Oli e Grassi. All rights reserved.