Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg
A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and highresolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa ce...
| Published in: | Natural Product Sciences |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Pharmacognosy
2023
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183853486&doi=10.20307%2fnps.2023.29.4.287&partnerID=40&md5=1304c69a98738e87d80d000a0a08f210 |
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2-s2.0-85183853486 |
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2-s2.0-85183853486 Tanjung M.; Tjahjandarie T.S.; Aldin M.F.; Mardhiyyah S.; Ahmat N.; Saputri R.D. Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg 2023 Natural Product Sciences 29 4 10.20307/nps.2023.29.4.287 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183853486&doi=10.20307%2fnps.2023.29.4.287&partnerID=40&md5=1304c69a98738e87d80d000a0a08f210 A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and highresolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa cells. Compound 1 showed potent activity against 4T1 cells with an IC50 value of 1.18 μg/mL, and compound 3 showed moderate activity against P-388 cells (IC50 value of 2.54 μg/mL). © 2023, Korean Society of Pharmacognosy. All rights reserved. Korean Society of Pharmacognosy 12263907 English Article All Open Access; Gold Open Access |
| author |
Tanjung M.; Tjahjandarie T.S.; Aldin M.F.; Mardhiyyah S.; Ahmat N.; Saputri R.D. |
| spellingShingle |
Tanjung M.; Tjahjandarie T.S.; Aldin M.F.; Mardhiyyah S.; Ahmat N.; Saputri R.D. Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg |
| author_facet |
Tanjung M.; Tjahjandarie T.S.; Aldin M.F.; Mardhiyyah S.; Ahmat N.; Saputri R.D. |
| author_sort |
Tanjung M.; Tjahjandarie T.S.; Aldin M.F.; Mardhiyyah S.; Ahmat N.; Saputri R.D. |
| title |
Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg |
| title_short |
Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg |
| title_full |
Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg |
| title_fullStr |
Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg |
| title_full_unstemmed |
Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg |
| title_sort |
Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg |
| publishDate |
2023 |
| container_title |
Natural Product Sciences |
| container_volume |
29 |
| container_issue |
4 |
| doi_str_mv |
10.20307/nps.2023.29.4.287 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183853486&doi=10.20307%2fnps.2023.29.4.287&partnerID=40&md5=1304c69a98738e87d80d000a0a08f210 |
| description |
A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and highresolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa cells. Compound 1 showed potent activity against 4T1 cells with an IC50 value of 1.18 μg/mL, and compound 3 showed moderate activity against P-388 cells (IC50 value of 2.54 μg/mL). © 2023, Korean Society of Pharmacognosy. All rights reserved. |
| publisher |
Korean Society of Pharmacognosy |
| issn |
12263907 |
| language |
English |
| format |
Article |
| accesstype |
All Open Access; Gold Open Access |
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1809677889203863552 |