Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg
A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and highresolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa ce...
| Published in: | Natural Product Sciences |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Pharmacognosy
2023
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183853486&doi=10.20307%2fnps.2023.29.4.287&partnerID=40&md5=1304c69a98738e87d80d000a0a08f210 |
| Summary: | A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and highresolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa cells. Compound 1 showed potent activity against 4T1 cells with an IC50 value of 1.18 μg/mL, and compound 3 showed moderate activity against P-388 cells (IC50 value of 2.54 μg/mL). © 2023, Korean Society of Pharmacognosy. All rights reserved. |
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| ISSN: | 12263907 |
| DOI: | 10.20307/nps.2023.29.4.287 |