The Ameliorative Effects of Phyllanthus gomphocarpus Hook. F. on Sperm Parameters of Rats Induced with Bisphenol A

Infertility due to poor sperm quality is a common problem nowadays, particularly in developed countries. Herbs are one of the natural treatment options that have been proposed. Phyllanthus gomphocarpus Hook. F is a tropical plant that has traditionally been used in Malaysia to treat male infertility...

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Published in:Majalah Obat Tradisional
Main Author: Kamarudin E.; Dasiman R.; Bahari E.A.; Daud K.A.; Suwandi N.R.
Format: Article
Language:English
Published: Universitas Gadjah Mada - Faculty of Pharmacy 2023
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183417840&doi=10.22146%2fmot.84823&partnerID=40&md5=6544d09fec169ccf38e0cc3912d43117
id 2-s2.0-85183417840
spelling 2-s2.0-85183417840
Kamarudin E.; Dasiman R.; Bahari E.A.; Daud K.A.; Suwandi N.R.
The Ameliorative Effects of Phyllanthus gomphocarpus Hook. F. on Sperm Parameters of Rats Induced with Bisphenol A
2023
Majalah Obat Tradisional
28
3
10.22146/mot.84823
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183417840&doi=10.22146%2fmot.84823&partnerID=40&md5=6544d09fec169ccf38e0cc3912d43117
Infertility due to poor sperm quality is a common problem nowadays, particularly in developed countries. Herbs are one of the natural treatment options that have been proposed. Phyllanthus gomphocarpus Hook. F is a tropical plant that has traditionally been used in Malaysia to treat male infertility. Antioxidant characterization of its root aqueous extraction was performed using ferric reducing antioxidant power (FRAP), 1,1-diphenyl-2-picrylhydrazyl (DPPH), total phenolic content (TPC), and total flavonoid content (TFC). Male rats were administered two different concentrations of the extract orally along with BPA for 21 days, and their sperm was evaluated using Computer-Assisted-Sperm-Analysis (CASA). The results showed that this plant has a high antioxidant capacity, with 78.6 ± 0.65 %, 0.14 ± 0.01 mg/ml, 28.52 ± 0.13 mg GAE/g and 164.73 ± 23.13 mg QE/g, for DPPH, FRAP, TPC and TFC respectively. The ability of this plant to enhance sperm concentration, motility, velocity, progression ratio, elongation, and percentages of normal sperm morphology significantly with p<0.05, appears to be due to its high antioxidant capacity. Furthermore, this plant was found to have sperm-protective effects against the endocrine disruptor BPA. A thorough investigation is required to determine the full mechanism of this plant's beneficial effects on male fertility and human health. © 2023, Universitas Gadjah Mada - Faculty of Pharmacy. All rights reserved.
Universitas Gadjah Mada - Faculty of Pharmacy
14105918
English
Article
All Open Access; Gold Open Access
author Kamarudin E.; Dasiman R.; Bahari E.A.; Daud K.A.; Suwandi N.R.
spellingShingle Kamarudin E.; Dasiman R.; Bahari E.A.; Daud K.A.; Suwandi N.R.
The Ameliorative Effects of Phyllanthus gomphocarpus Hook. F. on Sperm Parameters of Rats Induced with Bisphenol A
author_facet Kamarudin E.; Dasiman R.; Bahari E.A.; Daud K.A.; Suwandi N.R.
author_sort Kamarudin E.; Dasiman R.; Bahari E.A.; Daud K.A.; Suwandi N.R.
title The Ameliorative Effects of Phyllanthus gomphocarpus Hook. F. on Sperm Parameters of Rats Induced with Bisphenol A
title_short The Ameliorative Effects of Phyllanthus gomphocarpus Hook. F. on Sperm Parameters of Rats Induced with Bisphenol A
title_full The Ameliorative Effects of Phyllanthus gomphocarpus Hook. F. on Sperm Parameters of Rats Induced with Bisphenol A
title_fullStr The Ameliorative Effects of Phyllanthus gomphocarpus Hook. F. on Sperm Parameters of Rats Induced with Bisphenol A
title_full_unstemmed The Ameliorative Effects of Phyllanthus gomphocarpus Hook. F. on Sperm Parameters of Rats Induced with Bisphenol A
title_sort The Ameliorative Effects of Phyllanthus gomphocarpus Hook. F. on Sperm Parameters of Rats Induced with Bisphenol A
publishDate 2023
container_title Majalah Obat Tradisional
container_volume 28
container_issue 3
doi_str_mv 10.22146/mot.84823
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183417840&doi=10.22146%2fmot.84823&partnerID=40&md5=6544d09fec169ccf38e0cc3912d43117
description Infertility due to poor sperm quality is a common problem nowadays, particularly in developed countries. Herbs are one of the natural treatment options that have been proposed. Phyllanthus gomphocarpus Hook. F is a tropical plant that has traditionally been used in Malaysia to treat male infertility. Antioxidant characterization of its root aqueous extraction was performed using ferric reducing antioxidant power (FRAP), 1,1-diphenyl-2-picrylhydrazyl (DPPH), total phenolic content (TPC), and total flavonoid content (TFC). Male rats were administered two different concentrations of the extract orally along with BPA for 21 days, and their sperm was evaluated using Computer-Assisted-Sperm-Analysis (CASA). The results showed that this plant has a high antioxidant capacity, with 78.6 ± 0.65 %, 0.14 ± 0.01 mg/ml, 28.52 ± 0.13 mg GAE/g and 164.73 ± 23.13 mg QE/g, for DPPH, FRAP, TPC and TFC respectively. The ability of this plant to enhance sperm concentration, motility, velocity, progression ratio, elongation, and percentages of normal sperm morphology significantly with p<0.05, appears to be due to its high antioxidant capacity. Furthermore, this plant was found to have sperm-protective effects against the endocrine disruptor BPA. A thorough investigation is required to determine the full mechanism of this plant's beneficial effects on male fertility and human health. © 2023, Universitas Gadjah Mada - Faculty of Pharmacy. All rights reserved.
publisher Universitas Gadjah Mada - Faculty of Pharmacy
issn 14105918
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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