New piperidinyl heterocyclic azoles acquired through Li(I)-catalyzed reactions: Anti-enzymatic, ADME and computational studies
A biological impact of the fused heterocyclic rings as anti-enzymatic agents was explored through experimental, theoretical and computational studies. The targeted hybrids of 1,2,4-triazole (8a–q) were synthesized through multistep protocol. Initially, the carboxylate 3 was synthesized through stirr...
Published in: | Journal of Molecular Structure |
---|---|
Main Author: | Hamid S.; Amjad H.; Abbasi M.A.; Siddiqui S.Z.; Ashraf M.; Iqbal J.; Farhan M.; Rasool S.; Shah S.A.A.; Imran S.; Rehman M.T.; Rehman A.-U. |
Format: | Article |
Language: | English |
Published: |
Elsevier B.V.
2024
|
Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85182735120&doi=10.1016%2fj.molstruc.2024.137493&partnerID=40&md5=e0b65c9ed3a624a2476b227d81a22789 |
Similar Items
-
Multi-selective reaction of azinane bearing oxadiazoles and substituted haloalkanes catalyzed by alkali metal hydride to access anti-enzymatic agents
by: Umair M.; Aziz-ur-Rehman; Abbasi M.A.; Siddiqui S.Z.; Iqbal J.; Rasool S.; Khan S.U.; Shah S.A.A.
Published: (2024) -
Comparative conventional and microwave assisted synthesis of heterocyclic oxadiazole analogues having enzymatic inhibition potential
by: Javid J.; Aziz-ur-Rehman; Abbasi M.A.; Siddiqui S.Z.; Iqbal J.; Virk N.A.; Rasool S.; Ali H.A.; Ashraf M.; Shahid W.; Hussain S.; Ali Shah S.A.
Published: (2021) -
Synthesis of some new propanamide derivatives bearing 4-piperidinyl-1,3,4-oxadiazole, and their evaluation as promising anticancer agents
by: Aziz-Ur-Rehman; Ahtzaz N.; Abbasi M.A.; Siddiqui S.Z.; Saleem S.; Manzoor S.; Iqbal J.; Virk N.A.; Chohan T.A.; Shah S.A.A.
Published: (2018) -
Microwave-assisted synthesis of triazole derivatives conjugated with piperidine as new anti-enzymatic agents
by: Virk N.A.; Rehman A.-U.; Abbasi M.A.; Siddiqui S.Z.; Iqbal J.; Rasool S.; Khan S.U.; Htar T.T.; Khalid H.; Laulloo S.J.; Ali Shah S.A.
Published: (2020) -
Design of potent tyrosinase inhibiting N-arylated-4-yl-benzamides bearing 2-aminothiazole-triazole bi-heterocycles: mechanistic insight through enzyme inhibition, kinetics and computational studies
by: Khan, et al.
Published: (2024)