Chemical composition of essential oil from Lindera caesia Reinw. ex Fern.-Vill. and its antifungal, antibiofilm, and molecular docking studies

• Published in: Natural Product Research
• Main Author: Zaini N.N.M.; Salleh W.M.N.H.W.; Arzmi M.H.; Salihu A.S.; Ab Ghani N.
• Format: Article
• Language: English
• Published: Taylor and Francis Ltd. 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85180707152&doi=10.1080%2f14786419.2023.2298720&partnerID=40&md5=4d7d1d1872030124fa6b6fe94384eabd

The chemical composition, antifungal, antibiofilm, and molecular docking studies of the essential oil obtained from Lindera caesia were investigated. A total of thirty-nine components (96.7%) were identified using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The major components included terpinen-4-ol (26.3%), neo-intermedeol (23.2%), eudesma-4,11-dien-3-one (10.4%), and o-cymene (5.3%). The antifungal activity was tested against Candida albicans and Streptococcus mutans using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. The essential oil exhibited activity against C. albicans (MIC 125 µg/mL) and S. mutans (MIC 250 µg/mL), and increased the biofilm of C. albicans by 31.25% when treated with 500 µg/mL. The molecular docking study shows neo-intermedeol, eudesma-4,11-dien-3-one, α-selinene, and β-selinene as the good candidate to target Erg11 with a binding energy of −7.3 kcal/mol. These findings demonstrated that the essential oil may have potential in dental application for caries prevention. © 2023 Informa UK Limited, trading as Taylor & Francis Group.