Co-Supplementation of Vitamin E & Nigella sativa Improved the Endometrial Thickness in Mice

• Published in: International Journal of Anatomy and Research
• Main Author: Jalani S.M.; Jaafar N.H.; Mohamed R.; Mutalip S.S.M.
• Format: Article
• Language: English
• Published: IMED Research Publications 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85178892570&doi=10.16965%2fijar.2023.222&partnerID=40&md5=be3347e39f7f3948e6e6c553942e0ade

Background: The thin endometrial lining has been reported to be associated with significant complications in maintaining a healthy pregnancy. Studies have been conducted to find ways to improve this condition, and one of the possibilities is through micronutrient intake. Vitamin E and Nigella sativa (NS) are the two potential sources of micronutrients that could play essential roles in improving endometrial thickness. Purpose: The present study was conducted to determine the effect of vitamin E and NS supplementation on endometrial thickness in normal (not induced to any disease) mice. Methods: Twenty-four balb/c mice were divided into four groups with six mice each; Group A as negative control (no treatment), Group B given with vitamin E (400 mg/kg), Group C given with NS (200 mg/kg) and Group D given with both vitamin E (400 mg/kg) and NS (200 mg/kg). The uterus histological sections from each group were evaluated for endometrial thickness and other structures of the uterus components were also observed. Results: Co-supplementation of vitamin E and NS have a significantly higher endometrial thickness (131.84 + 14.48ìm) compared to the control group (88.08 + 11.49ìm) and other uterus structures were not disrupted. Conclusion: The co-supplementation of vitamin E and NS could enhance the endometrial thickness without inducing any disruption to the other structures of the uterus. © 2023, IMED Research Publications. All rights reserved.