Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data

Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair...

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Published in:World Journal of Men's Health
Main Author: Cannarella R.; Shah R.; Abo-Almagd Abdel-Meguid Hamoda T.; Boitrelle F.; Saleh R.; Gul M.; Rambhatla A.; Kavoussi P.; Toprak T.; Harraz A.M.; Ko E.; Çeker G.; Durairajanayagam D.; Alkahidi N.; Kuroda S.; Crafa A.; Henkel R.; Salvio G.; Hazir B.; Darbandi M.; Bendayan M.; Darbandi S.; Falcone M.; Garrido N.; Kosgi R.; Kaiyal R.S.; Karna K.; Ho Vinh Phuoc N.; Birowo P.; Colpi G.M.; de la Rosette J.; Pinggera G.-M.; Nguyen Q.; Zini A.; Zohdy W.; Singh R.; Saini P.; Glina S.; Lin H.; Mostafa T.; Rojas-Cruz C.; Arafa M.; Calogero A.E.; Dimitriadis F.; Kothari P.; Karthikeyan V.S.; Okada K.; Chiba K.; Kadıoglu A.; Altay B.; Turunc T.; Zilaitiene B.; Gokalp F.; Adamyan A.; Katz D.; Chung E.; Mierzwa T.C.; Zylbersztejn D.S.; Paul G.M.; Sofikitis N.; Sokolakis I.; Malhotra V.; Brodjonegoro S.R.; Adriansjah R.; Tsujimura A.; Amano T.; Balercia G.; Ziouziou I.; Deswanto I.A.; Martinez M.; Park H.J.; Bakırcıoglu M.E.; Ceyhan E.; Aydos K.; Ramsay J.; Minhas S.; Hashimi M.A.; Ghayda R.A.; Tadros N.; Sindhwani P.; Ho C.C.K.; Rachman R.I.; Pena M.R.; Motawi A.; Ponnusamy A.K.; Dipankar S.; Amir A.; Binsaleh S.; Serefoglu E.C.; Banthia R.; Khalafalla K.; Basukarno A.; Bac N.H.; Singla K.; Ambar R.F.; Makarounis K.; Priyadarshi S.; Kusuma Duarsa G.W.; Atmoko W.; Jindal S.; Arianto E.; Akhavizadegan H.; Bardisi H.E.; Shoshany O.; Busetto G.M.; Moussa M.; Jamali M.; Al-Marhoon M.S.; Ruzaev M.; Farsi H.M.A.; Mutambirwa S.; Lee D.S.; Kulaksiz D.; Cheng Y.-S.; Bouzouita A.; Sarikaya S.; Kandil H.; Tsampoukas G.; Ala’a F.; Bowa K.; Savira M.; Mogharabian N.; Le T.V.; Harjanggi M.; Anh D.T.; Tien Long T.Q.; Soebadi M.A.; Hakim L.; Tanic M.; Ari U.C.; Parikh F.R.; Calik G.; Vinod K.V.; Dorji G.; Rezano A.; Rajmil O.; Ba Tien D.M.; Yuan Y.; Lizarraga-Salas J.F.; Eze B.; Ngoo K.S.; Lee J.; Arslan U.; Agarwal A.
Format: Article
Language:English
Published: Korean Society for Sexual Medicine and Andrology 2023
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175731583&doi=10.5534%2fwjmh.230034&partnerID=40&md5=bd6ca66a020398497f71a383d1c623e7
id 2-s2.0-85175731583
spelling 2-s2.0-85175731583
Cannarella R.; Shah R.; Abo-Almagd Abdel-Meguid Hamoda T.; Boitrelle F.; Saleh R.; Gul M.; Rambhatla A.; Kavoussi P.; Toprak T.; Harraz A.M.; Ko E.; Çeker G.; Durairajanayagam D.; Alkahidi N.; Kuroda S.; Crafa A.; Henkel R.; Salvio G.; Hazir B.; Darbandi M.; Bendayan M.; Darbandi S.; Falcone M.; Garrido N.; Kosgi R.; Kaiyal R.S.; Karna K.; Ho Vinh Phuoc N.; Birowo P.; Colpi G.M.; de la Rosette J.; Pinggera G.-M.; Nguyen Q.; Zini A.; Zohdy W.; Singh R.; Saini P.; Glina S.; Lin H.; Mostafa T.; Rojas-Cruz C.; Arafa M.; Calogero A.E.; Dimitriadis F.; Kothari P.; Karthikeyan V.S.; Okada K.; Chiba K.; Kadıoglu A.; Altay B.; Turunc T.; Zilaitiene B.; Gokalp F.; Adamyan A.; Katz D.; Chung E.; Mierzwa T.C.; Zylbersztejn D.S.; Paul G.M.; Sofikitis N.; Sokolakis I.; Malhotra V.; Brodjonegoro S.R.; Adriansjah R.; Tsujimura A.; Amano T.; Balercia G.; Ziouziou I.; Deswanto I.A.; Martinez M.; Park H.J.; Bakırcıoglu M.E.; Ceyhan E.; Aydos K.; Ramsay J.; Minhas S.; Hashimi M.A.; Ghayda R.A.; Tadros N.; Sindhwani P.; Ho C.C.K.; Rachman R.I.; Pena M.R.; Motawi A.; Ponnusamy A.K.; Dipankar S.; Amir A.; Binsaleh S.; Serefoglu E.C.; Banthia R.; Khalafalla K.; Basukarno A.; Bac N.H.; Singla K.; Ambar R.F.; Makarounis K.; Priyadarshi S.; Kusuma Duarsa G.W.; Atmoko W.; Jindal S.; Arianto E.; Akhavizadegan H.; Bardisi H.E.; Shoshany O.; Busetto G.M.; Moussa M.; Jamali M.; Al-Marhoon M.S.; Ruzaev M.; Farsi H.M.A.; Mutambirwa S.; Lee D.S.; Kulaksiz D.; Cheng Y.-S.; Bouzouita A.; Sarikaya S.; Kandil H.; Tsampoukas G.; Ala’a F.; Bowa K.; Savira M.; Mogharabian N.; Le T.V.; Harjanggi M.; Anh D.T.; Tien Long T.Q.; Soebadi M.A.; Hakim L.; Tanic M.; Ari U.C.; Parikh F.R.; Calik G.; Vinod K.V.; Dorji G.; Rezano A.; Rajmil O.; Ba Tien D.M.; Yuan Y.; Lizarraga-Salas J.F.; Eze B.; Ngoo K.S.; Lee J.; Arslan U.; Agarwal A.
Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
2023
World Journal of Men's Health
41

10.5534/wjmh.230034
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175731583&doi=10.5534%2fwjmh.230034&partnerID=40&md5=bd6ca66a020398497f71a383d1c623e7
Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles. Materials and Methods: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies). Results: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129–0.278; p<0.001; I2=83.62%, Egger’s p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474–1.706; p<0.001; I2=97.86%, Egger’s p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526–2.121; p<0.001; I2=97.88%, Egger’s p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318–1.968; p<0.001; I2=98.65%, Egger’s p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%–2.153%; p<0.001; I2=98.97%, Egger’s p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%–1.759%; p<0.001; l2=97.98%, Egger’s p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%–1.211%; p<0.001; I2=97.87%, Egger’s p=0.1864. Conclusions: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele. © 2023 World J Mens Healt. All rights reserved.
Korean Society for Sexual Medicine and Andrology
22874208
English
Article
All Open Access; Gold Open Access
author Cannarella R.; Shah R.; Abo-Almagd Abdel-Meguid Hamoda T.; Boitrelle F.; Saleh R.; Gul M.; Rambhatla A.; Kavoussi P.; Toprak T.; Harraz A.M.; Ko E.; Çeker G.; Durairajanayagam D.; Alkahidi N.; Kuroda S.; Crafa A.; Henkel R.; Salvio G.; Hazir B.; Darbandi M.; Bendayan M.; Darbandi S.; Falcone M.; Garrido N.; Kosgi R.; Kaiyal R.S.; Karna K.; Ho Vinh Phuoc N.; Birowo P.; Colpi G.M.; de la Rosette J.; Pinggera G.-M.; Nguyen Q.; Zini A.; Zohdy W.; Singh R.; Saini P.; Glina S.; Lin H.; Mostafa T.; Rojas-Cruz C.; Arafa M.; Calogero A.E.; Dimitriadis F.; Kothari P.; Karthikeyan V.S.; Okada K.; Chiba K.; Kadıoglu A.; Altay B.; Turunc T.; Zilaitiene B.; Gokalp F.; Adamyan A.; Katz D.; Chung E.; Mierzwa T.C.; Zylbersztejn D.S.; Paul G.M.; Sofikitis N.; Sokolakis I.; Malhotra V.; Brodjonegoro S.R.; Adriansjah R.; Tsujimura A.; Amano T.; Balercia G.; Ziouziou I.; Deswanto I.A.; Martinez M.; Park H.J.; Bakırcıoglu M.E.; Ceyhan E.; Aydos K.; Ramsay J.; Minhas S.; Hashimi M.A.; Ghayda R.A.; Tadros N.; Sindhwani P.; Ho C.C.K.; Rachman R.I.; Pena M.R.; Motawi A.; Ponnusamy A.K.; Dipankar S.; Amir A.; Binsaleh S.; Serefoglu E.C.; Banthia R.; Khalafalla K.; Basukarno A.; Bac N.H.; Singla K.; Ambar R.F.; Makarounis K.; Priyadarshi S.; Kusuma Duarsa G.W.; Atmoko W.; Jindal S.; Arianto E.; Akhavizadegan H.; Bardisi H.E.; Shoshany O.; Busetto G.M.; Moussa M.; Jamali M.; Al-Marhoon M.S.; Ruzaev M.; Farsi H.M.A.; Mutambirwa S.; Lee D.S.; Kulaksiz D.; Cheng Y.-S.; Bouzouita A.; Sarikaya S.; Kandil H.; Tsampoukas G.; Ala’a F.; Bowa K.; Savira M.; Mogharabian N.; Le T.V.; Harjanggi M.; Anh D.T.; Tien Long T.Q.; Soebadi M.A.; Hakim L.; Tanic M.; Ari U.C.; Parikh F.R.; Calik G.; Vinod K.V.; Dorji G.; Rezano A.; Rajmil O.; Ba Tien D.M.; Yuan Y.; Lizarraga-Salas J.F.; Eze B.; Ngoo K.S.; Lee J.; Arslan U.; Agarwal A.
spellingShingle Cannarella R.; Shah R.; Abo-Almagd Abdel-Meguid Hamoda T.; Boitrelle F.; Saleh R.; Gul M.; Rambhatla A.; Kavoussi P.; Toprak T.; Harraz A.M.; Ko E.; Çeker G.; Durairajanayagam D.; Alkahidi N.; Kuroda S.; Crafa A.; Henkel R.; Salvio G.; Hazir B.; Darbandi M.; Bendayan M.; Darbandi S.; Falcone M.; Garrido N.; Kosgi R.; Kaiyal R.S.; Karna K.; Ho Vinh Phuoc N.; Birowo P.; Colpi G.M.; de la Rosette J.; Pinggera G.-M.; Nguyen Q.; Zini A.; Zohdy W.; Singh R.; Saini P.; Glina S.; Lin H.; Mostafa T.; Rojas-Cruz C.; Arafa M.; Calogero A.E.; Dimitriadis F.; Kothari P.; Karthikeyan V.S.; Okada K.; Chiba K.; Kadıoglu A.; Altay B.; Turunc T.; Zilaitiene B.; Gokalp F.; Adamyan A.; Katz D.; Chung E.; Mierzwa T.C.; Zylbersztejn D.S.; Paul G.M.; Sofikitis N.; Sokolakis I.; Malhotra V.; Brodjonegoro S.R.; Adriansjah R.; Tsujimura A.; Amano T.; Balercia G.; Ziouziou I.; Deswanto I.A.; Martinez M.; Park H.J.; Bakırcıoglu M.E.; Ceyhan E.; Aydos K.; Ramsay J.; Minhas S.; Hashimi M.A.; Ghayda R.A.; Tadros N.; Sindhwani P.; Ho C.C.K.; Rachman R.I.; Pena M.R.; Motawi A.; Ponnusamy A.K.; Dipankar S.; Amir A.; Binsaleh S.; Serefoglu E.C.; Banthia R.; Khalafalla K.; Basukarno A.; Bac N.H.; Singla K.; Ambar R.F.; Makarounis K.; Priyadarshi S.; Kusuma Duarsa G.W.; Atmoko W.; Jindal S.; Arianto E.; Akhavizadegan H.; Bardisi H.E.; Shoshany O.; Busetto G.M.; Moussa M.; Jamali M.; Al-Marhoon M.S.; Ruzaev M.; Farsi H.M.A.; Mutambirwa S.; Lee D.S.; Kulaksiz D.; Cheng Y.-S.; Bouzouita A.; Sarikaya S.; Kandil H.; Tsampoukas G.; Ala’a F.; Bowa K.; Savira M.; Mogharabian N.; Le T.V.; Harjanggi M.; Anh D.T.; Tien Long T.Q.; Soebadi M.A.; Hakim L.; Tanic M.; Ari U.C.; Parikh F.R.; Calik G.; Vinod K.V.; Dorji G.; Rezano A.; Rajmil O.; Ba Tien D.M.; Yuan Y.; Lizarraga-Salas J.F.; Eze B.; Ngoo K.S.; Lee J.; Arslan U.; Agarwal A.
Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
author_facet Cannarella R.; Shah R.; Abo-Almagd Abdel-Meguid Hamoda T.; Boitrelle F.; Saleh R.; Gul M.; Rambhatla A.; Kavoussi P.; Toprak T.; Harraz A.M.; Ko E.; Çeker G.; Durairajanayagam D.; Alkahidi N.; Kuroda S.; Crafa A.; Henkel R.; Salvio G.; Hazir B.; Darbandi M.; Bendayan M.; Darbandi S.; Falcone M.; Garrido N.; Kosgi R.; Kaiyal R.S.; Karna K.; Ho Vinh Phuoc N.; Birowo P.; Colpi G.M.; de la Rosette J.; Pinggera G.-M.; Nguyen Q.; Zini A.; Zohdy W.; Singh R.; Saini P.; Glina S.; Lin H.; Mostafa T.; Rojas-Cruz C.; Arafa M.; Calogero A.E.; Dimitriadis F.; Kothari P.; Karthikeyan V.S.; Okada K.; Chiba K.; Kadıoglu A.; Altay B.; Turunc T.; Zilaitiene B.; Gokalp F.; Adamyan A.; Katz D.; Chung E.; Mierzwa T.C.; Zylbersztejn D.S.; Paul G.M.; Sofikitis N.; Sokolakis I.; Malhotra V.; Brodjonegoro S.R.; Adriansjah R.; Tsujimura A.; Amano T.; Balercia G.; Ziouziou I.; Deswanto I.A.; Martinez M.; Park H.J.; Bakırcıoglu M.E.; Ceyhan E.; Aydos K.; Ramsay J.; Minhas S.; Hashimi M.A.; Ghayda R.A.; Tadros N.; Sindhwani P.; Ho C.C.K.; Rachman R.I.; Pena M.R.; Motawi A.; Ponnusamy A.K.; Dipankar S.; Amir A.; Binsaleh S.; Serefoglu E.C.; Banthia R.; Khalafalla K.; Basukarno A.; Bac N.H.; Singla K.; Ambar R.F.; Makarounis K.; Priyadarshi S.; Kusuma Duarsa G.W.; Atmoko W.; Jindal S.; Arianto E.; Akhavizadegan H.; Bardisi H.E.; Shoshany O.; Busetto G.M.; Moussa M.; Jamali M.; Al-Marhoon M.S.; Ruzaev M.; Farsi H.M.A.; Mutambirwa S.; Lee D.S.; Kulaksiz D.; Cheng Y.-S.; Bouzouita A.; Sarikaya S.; Kandil H.; Tsampoukas G.; Ala’a F.; Bowa K.; Savira M.; Mogharabian N.; Le T.V.; Harjanggi M.; Anh D.T.; Tien Long T.Q.; Soebadi M.A.; Hakim L.; Tanic M.; Ari U.C.; Parikh F.R.; Calik G.; Vinod K.V.; Dorji G.; Rezano A.; Rajmil O.; Ba Tien D.M.; Yuan Y.; Lizarraga-Salas J.F.; Eze B.; Ngoo K.S.; Lee J.; Arslan U.; Agarwal A.
author_sort Cannarella R.; Shah R.; Abo-Almagd Abdel-Meguid Hamoda T.; Boitrelle F.; Saleh R.; Gul M.; Rambhatla A.; Kavoussi P.; Toprak T.; Harraz A.M.; Ko E.; Çeker G.; Durairajanayagam D.; Alkahidi N.; Kuroda S.; Crafa A.; Henkel R.; Salvio G.; Hazir B.; Darbandi M.; Bendayan M.; Darbandi S.; Falcone M.; Garrido N.; Kosgi R.; Kaiyal R.S.; Karna K.; Ho Vinh Phuoc N.; Birowo P.; Colpi G.M.; de la Rosette J.; Pinggera G.-M.; Nguyen Q.; Zini A.; Zohdy W.; Singh R.; Saini P.; Glina S.; Lin H.; Mostafa T.; Rojas-Cruz C.; Arafa M.; Calogero A.E.; Dimitriadis F.; Kothari P.; Karthikeyan V.S.; Okada K.; Chiba K.; Kadıoglu A.; Altay B.; Turunc T.; Zilaitiene B.; Gokalp F.; Adamyan A.; Katz D.; Chung E.; Mierzwa T.C.; Zylbersztejn D.S.; Paul G.M.; Sofikitis N.; Sokolakis I.; Malhotra V.; Brodjonegoro S.R.; Adriansjah R.; Tsujimura A.; Amano T.; Balercia G.; Ziouziou I.; Deswanto I.A.; Martinez M.; Park H.J.; Bakırcıoglu M.E.; Ceyhan E.; Aydos K.; Ramsay J.; Minhas S.; Hashimi M.A.; Ghayda R.A.; Tadros N.; Sindhwani P.; Ho C.C.K.; Rachman R.I.; Pena M.R.; Motawi A.; Ponnusamy A.K.; Dipankar S.; Amir A.; Binsaleh S.; Serefoglu E.C.; Banthia R.; Khalafalla K.; Basukarno A.; Bac N.H.; Singla K.; Ambar R.F.; Makarounis K.; Priyadarshi S.; Kusuma Duarsa G.W.; Atmoko W.; Jindal S.; Arianto E.; Akhavizadegan H.; Bardisi H.E.; Shoshany O.; Busetto G.M.; Moussa M.; Jamali M.; Al-Marhoon M.S.; Ruzaev M.; Farsi H.M.A.; Mutambirwa S.; Lee D.S.; Kulaksiz D.; Cheng Y.-S.; Bouzouita A.; Sarikaya S.; Kandil H.; Tsampoukas G.; Ala’a F.; Bowa K.; Savira M.; Mogharabian N.; Le T.V.; Harjanggi M.; Anh D.T.; Tien Long T.Q.; Soebadi M.A.; Hakim L.; Tanic M.; Ari U.C.; Parikh F.R.; Calik G.; Vinod K.V.; Dorji G.; Rezano A.; Rajmil O.; Ba Tien D.M.; Yuan Y.; Lizarraga-Salas J.F.; Eze B.; Ngoo K.S.; Lee J.; Arslan U.; Agarwal A.
title Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
title_short Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
title_full Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
title_fullStr Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
title_full_unstemmed Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
title_sort Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
publishDate 2023
container_title World Journal of Men's Health
container_volume 41
container_issue
doi_str_mv 10.5534/wjmh.230034
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175731583&doi=10.5534%2fwjmh.230034&partnerID=40&md5=bd6ca66a020398497f71a383d1c623e7
description Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles. Materials and Methods: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies). Results: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129–0.278; p<0.001; I2=83.62%, Egger’s p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474–1.706; p<0.001; I2=97.86%, Egger’s p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526–2.121; p<0.001; I2=97.88%, Egger’s p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318–1.968; p<0.001; I2=98.65%, Egger’s p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%–2.153%; p<0.001; I2=98.97%, Egger’s p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%–1.759%; p<0.001; l2=97.98%, Egger’s p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%–1.211%; p<0.001; I2=97.87%, Egger’s p=0.1864. Conclusions: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele. © 2023 World J Mens Healt. All rights reserved.
publisher Korean Society for Sexual Medicine and Andrology
issn 22874208
language English
format Article
accesstype All Open Access; Gold Open Access
record_format scopus
collection Scopus
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