Crosslinked carboxymethyl cellulose colloidal solution for cotton thread coating in wound dressing: A rheological study

• Published in: International Journal of Biological Macromolecules
• Main Author: Khairunnisa-Atiqah M.K.; Salleh K.M.; Hair A.H.A.; Mazlan N.S.N.; Mostapha M.; Zakaria S.
• Format: Article
• Language: English
• Published: Elsevier B.V. 2023
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174673620&doi=10.1016%2fj.ijbiomac.2023.127518&partnerID=40&md5=ff5689fee735e08643833ba7d95c1dac

Cotton thread therapeutic properties as a wound dressing can be enhanced by utilising carboxymethyl cellulose-nanoparticles (CMC/NPs) colloidal solution as a coating solution. Nanoparticles such as graphene oxide (GO), graphene quantum dots (GQD), and silver nanoparticles (AgNP) stability in CMC was investigated through the rheological analysis and UV–Vis spectroscopy of the colloidal solutions. Citric acid (CA) acted as a crosslinker and was utilised to crosslink the colloidal solution with cotton thread. These CMC/NPs coated threads were subjected to mechanical properties and antibacterial activity analysis. Results obtained indicate less nanoparticle agglomeration and were stable in the CMC-based nanofluid. CMC/NPs rheological study suggested that colloidal solutions exhibited shear thinning behaviour and behaved as non-Newtonian fluids with n < 1. Crosslinked CMC/NPs appeared in a gel-like state as the viscoelasticity of the solution increased. Among the colloidal solutions, CMC/AgNP showed the highest enhancement with a significant difference at p < 0.05 in terms of mechanical and antibacterial properties. Consequently, the rheological properties and stability of CMC/NPs might influence the coating solution's appearance and refine the cotton thread's microstructure for a functional wound dressing to be further utilised as a coating solution for antibacterial cotton thread wound dressing material. © 2023 Elsevier B.V.